IMMUNOGLOBULIN A (IGA) LEVELS IN HEALTHY BLOOD DONORS IN YAOUNDE, CAMEROON

Marie Claire Okomo Assoumou, E Akongnwi Mugyia, Agnes Esiène, G Ikomey Mondinde, M Mesembe, D Adiogo, J Atashili, E E Lyonga, A Eyoh, Peter Ndumbe

Abstract


Background and Objectives: IgA deficient patients are at risk of severe life-threatening anaphylactic reaction on being transfused blood or blood products. This study aimed at assessing the prevalence of IgA deficiency in blood donors in Yaounde, Cameroon.

 

Methods: Serum samples were collected from 670 apparently healthy blood donors. Enzyme linked Immunosorbent Assay (ELISA) was used to quantitate total IgA concentration.

 

Results: Of the 670 samples tested, 536 (80%) were from males and 134 (20%) from females. Age ranged from 17 to 58 with a mean of 28.3 ± 7years. There were no patients with IgA deficiency (IgA <5mg/dL); 11 persons (1.6%) with partial IgA deficiency (5-30mg/dL); 535 (79.9%) with normal IgA (31-450mg/dL) and 124 (18.5%) with greater than normal IgA levels. The concentration of IgA varied by sex, with females having significantly higher levels than males (p=0.002). The mean IgA

concentration generally increased with increasing age, p=0.001).

 

Conclusion: This study suggests that IgA deficiencies are rare in the study group and may not be a major clinical concern in our setting.


Keywords


: Immunoglobulin A levels; Blood donors; Serum samples; IgA deficiency; Cameroon.

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