Quality Assessment of Analgesics Paracetamol and Ibuprofen for Sale in the Douala City (Cameroon)
Introduction. Research Institute Against Counterfeit and the Organization for Economic Cooperation and Development Drugs estimate that 700,000 deaths per year due to malaria and TB bad. According to the World Health Organization (WHO), the street drugs kill at least 100,000 people in Africa every year, 1/3 of these drugs are counterfeit, Asia and Latin America are not spared. The objective of this study was to evaluate the quality of paracetamol tablets (500 mg) and ibuprofen (400 mg) for sale in the markets and Ndokoti Central Douala in Cameroon. Methodology. This was an experimental study which took place from 4 December 2013 to 12 June 2014. The sampling was non-exhaustive consecutive kind. The analyzes focused on the visual, technical pharmacological tests reported in the European Pharmacopoeia 2011 version 7.0 page 270; 292; 769 and 770. The data were analyzed using the Statistical Package for Social Science (SPSS) 20.0 for Windows and graphics the Microsoft Excel program. Results. The work has focused on 39 batches, 15 (38.46%) were molecules of paracetamol and 24 (61.54%) of ibuprofen; 18 (46.15%) were from batches of the central market and 21 (53.85%) of Ndokoti. Visual inspection showed 25 lots (64.10%) non-compliant. Resistance testing at failure presented 12 (80%) batches of paracetamol and 22 (91.67%) of non-compliant ibuprofen. The disintegration test showed 05 (33.33%) of paracetamol lots and 03 (12.5%) non-compliant batches of ibuprofen. The mass uniformity test showed 2 lots (8.34%) of non-compliance for ibuprofen. The size measurement showed no noncompliance. All paracetamol tablets were consistent with the dosage. Conclusion. Visual inspection presented nonconformities paracetamol and lots of ibuprofen. This non-compliance was plausible in the central market. Pharmaco-technical tests showed nonconformities and Ndokoti market showed high percentages.
Introduction. Counterfeit drugs Constitute serious global phenomenon. The Research Institute contre Counterfeit Drugs and the Organization for Economic Cooperation and Development estimate That Deaths 700,000 per year are due to counterfeit antimalarial and antituberculosis drugs. According To the World Health Organization, "street drugs" kill at least 100,000 persons per year in Africa, and In Some countries of Africa, Asia and Latin America, one third of drugs are counterfeit. The objective of this work is to the quality for Assessment of ibuprofen and paracetamol tablets sold in illegitimate pharmacy outlets ( "street pharmacy turf gold") of Ndokoti and Central markets of Douala, Cameroon. Methodology. This was an experimental study ran from December 04, 2013 to June 12, 2014. Sampling Was consecutive non-exhaustive. The Concerned analyzes the visual control and the pharmaco-technical tests Recorded in the European Pharmacopoeia 2011 version 7.0 of 270 pages; 292; 769 and 770. The data Was Analyzed using SPSS 20.0 software for Windows and the graphics representations required the Microsoft Excel program. Results. The work Involved 39 batches, 15 (38.46%) and paracetamol Were 24 (61.54%) ibuprofen; 18 (46.15%) cam batches from the central market and 21 (53.85%) from Ndokoti. Visual inspection Showed 25 lots (64.10%) Were non-compliant. The breaking strength test Showed 12 (80%) lots of paracetamol and 22 (91.67%) of ibuprofen Were non-compliant. The disintegration test Showed 05 (33.33%) lots of paracetamol and 03 (12.5%) lots of ibuprofen Were non-compliant. The mass uniformity test Showed 2 lots (8.34%) of non-conformities for ibuprofen. The dimension measurement Did not Reveal Any non-compliance. All paracetamol tablets contained the active ingredient in Sufficient quantity. Conclusion. Visual inspection of nonconformities Showed Both batches of paracetamol and ibuprofen. These non-conformities Were plausible in the central market. The Ndokoti Market Showed Highest Percentages of nonconformities concernant pharmaco-technical tests.
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