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Abstract
RÉSUMÉ
La thyroïdite granulomateuse subaiguë ou thyroïdite de De Quervain est une inflammation rare de la glande thyroïde généralement d’origine virale. Elle se caractérise au plan histologique par un infiltrat granulomateux avec cellules géantes multinucléées. Nous rapportons ici trois cas de patientes admises pour goitre chez lesquelles une thyroïdite granulomateuse de DE Quervain, dans une forme paucisymptomatique a été retenue. Les trois observations cocnernaient les patientes âgées de 28, 38 et 48 ans. On notait une absence d’antécédents personnels ou familiaux de pathologies thyroïdiennes chez l’ensemble de nos patientes ainsi que l’inexistence de facteurs de risque de thyroïdopathies. Cliniquement, nos patientes présentaient toutes un goitre cervical antérieur, sensible avec gène esthétique et signes de compression. Le diagnostic de certitude a été portée après l’examen histologique post-thyroïdectomie. Nous décrivons le profil clinico-histologique de ces cas ainsi qu’une revue de la littérature.
ABSTRACT
Subacute granulomatous thyroiditis or De Quervain's thyroiditis is a rare inflammation of the thyroid gland, generally of viral origin. Histologically, it is characterised by a granulomatous infiltrate with multinucleated giant cells. We report three cases of patients admitted for goitre in whom a granulomatous thyroiditis of De Quervain, in a paucisymptomatic form, was retained. The three cases concerned patients aged 28, 38 and 48 years. All patients had no personal or family history of thyroid disease and no risk factors of thyroid disease. Clinically, all our patients, had a tender anterior cervical goitre with cosmetic discomfort and signs of compression. The diagnosis of certainty was made after histological examination following thyroidectomy. We describe the clinico-histological profile of these cases and review the pertinent literature.
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References
- 1. Li Y, Hu Y, Zhang Y, Cheng K, Zhang C, Wang J. Advances in Subacute Thyroiditis: Pathogenesis, Diagnosis, and Therapies. FASEB J. 2025 ;39(7):e70525.
- 2. Ranganath R, Shaha MA, Xu B, Migliacci J, Ghossein R, Shaha AR. de Quervain's thyroiditis: A review of experience with surgery. Am J Otolaryngol. 2016;37(6):534-537
- 3. Oláh R, Hajós P, Soós Z, Winkler G. A szubakut de Quervain-thyreoiditis. A kórismézés sarokpontjai négy eset kapcsán [De Quervain thyroiditis. Corner points of the diagnosis]. Orv Hetil. 2014 ;155(17) :676-80.
- 4. Meachim G, Young MH. De Quervain's subacute granulomatous thyroiditis: histological identification and incidence. J Clin Pathol. 1963;16(3):189-99.
- 5. Sahin D, Akpolat İ. Diagnostic cytological features and differential diagnosis of subacute granulomatous (De Quervain's) thyroiditis. Diagn Cytopathol. 2019;47(12):1251-1258
- 6. Engkakul P, Mahachoklertwattana P, Poomthavorn P. Eponym : de Quervain thyroiditis. Eur J Pediatr. 2011 ;170(4):427-31.
- 7. Vural Ç, Paksoy N, Gök ND, Yazal K. Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases. Cytojournal. 2015;12 :9.
- 8. Al Hassan MS, El Ansari W, Petkar M, Al Sharani SA, Abdelaal A. Subacute (De Quervain's) thyroiditis presenting as painful thyroid nodule suspicious of papillary thyroid carcinoma: Case report. Int J Surg Case Rep. 2022 ;96:107329.
- 9. Mundy-Baird G, Kyriacou A, Syed AA. De Quervain subacute thyroiditis. CMAJ. 2021;193(26):E1007
- 10. Agnihotri M, Kothari K, Monteiro R. Cytodiagnosis of subacute granulomatous thyroiditis (De Quervain's thyroiditis)-A report of four cases. Diagn Cytopathol. 2024;52(1):E30-E33.
- 11. Duininck TM, van Heerden JA, Fatourechi V, Curlee KJ, Farley DR, Thompson GB, Grant CS, Lloyd RV. de Quervain's thyroiditis: surgical experience. Endocr Pract. 2002;8(4):255-8.
- 12. Lamichaney R, Sherpa M, Das D, Bhutia CT, Laishram S. Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases. J Clin Diagn Res. 2017;11(8):EC09-EC11.
- 13. Kunz A, Blank W, Braun B. De Quervain's subacute thyroiditis -- colour Doppler sonography findings. Ultraschall Med. 2005;26(2):102-6.
- 14. Slatosky J, Shipton B, Wahba H. Thyroiditis: differential diagnosis and management. Am Fam Physician. 2000 Feb 15;61(4):1047-52, 1054. Erratum in: Am Fam Physician 2000 ;62(2):318.
- 15. Stasiak M, Lewiński A. New aspects in the pathogenesis and management of subacute thyroiditis. Rev Endocr Metab Disord. 2021 ;22(4):1027-1039.
- 16. Sow DS, Mariko M , Traoré D et al. Les Thyroïdites à l’Hôpital du Mali : Aspects Diagnostiques, Thérapeutiques et Évolutifs. Health Sci. Dis. 2021 ; 22 (9): 35-38
- 17. Stancek D, Ciampor F, Mucha V, Hnilica P, Stancekova M. Morphological, cytological and biological observations on viruses isolated from patients with subacute thyroiditis de Quervain. Acta Virol. 1976 ;20(3):183-8
- 18. Angel M, Cano JF, del Olmo A, Rives A, Balcells A. Sarcoidosis, adenoma tóxico de tiroides y tiroiditis de De Quervain : asociación o coincidencia? [Sarcoidosis, toxic thyroid adenoma, and De Quervain's thyroiditis. Association or coincidence (author's transl)]. Med Clin (Barc). 1979 ;72(9):384-7
References
1. Li Y, Hu Y, Zhang Y, Cheng K, Zhang C, Wang J. Advances in Subacute Thyroiditis: Pathogenesis, Diagnosis, and Therapies. FASEB J. 2025 ;39(7):e70525.
2. Ranganath R, Shaha MA, Xu B, Migliacci J, Ghossein R, Shaha AR. de Quervain's thyroiditis: A review of experience with surgery. Am J Otolaryngol. 2016;37(6):534-537
3. Oláh R, Hajós P, Soós Z, Winkler G. A szubakut de Quervain-thyreoiditis. A kórismézés sarokpontjai négy eset kapcsán [De Quervain thyroiditis. Corner points of the diagnosis]. Orv Hetil. 2014 ;155(17) :676-80.
4. Meachim G, Young MH. De Quervain's subacute granulomatous thyroiditis: histological identification and incidence. J Clin Pathol. 1963;16(3):189-99.
5. Sahin D, Akpolat İ. Diagnostic cytological features and differential diagnosis of subacute granulomatous (De Quervain's) thyroiditis. Diagn Cytopathol. 2019;47(12):1251-1258
6. Engkakul P, Mahachoklertwattana P, Poomthavorn P. Eponym : de Quervain thyroiditis. Eur J Pediatr. 2011 ;170(4):427-31.
7. Vural Ç, Paksoy N, Gök ND, Yazal K. Subacute granulomatous (De Quervain's) thyroiditis: Fine-needle aspiration cytology and ultrasonographic characteristics of 21 cases. Cytojournal. 2015;12 :9.
8. Al Hassan MS, El Ansari W, Petkar M, Al Sharani SA, Abdelaal A. Subacute (De Quervain's) thyroiditis presenting as painful thyroid nodule suspicious of papillary thyroid carcinoma: Case report. Int J Surg Case Rep. 2022 ;96:107329.
9. Mundy-Baird G, Kyriacou A, Syed AA. De Quervain subacute thyroiditis. CMAJ. 2021;193(26):E1007
10. Agnihotri M, Kothari K, Monteiro R. Cytodiagnosis of subacute granulomatous thyroiditis (De Quervain's thyroiditis)-A report of four cases. Diagn Cytopathol. 2024;52(1):E30-E33.
11. Duininck TM, van Heerden JA, Fatourechi V, Curlee KJ, Farley DR, Thompson GB, Grant CS, Lloyd RV. de Quervain's thyroiditis: surgical experience. Endocr Pract. 2002;8(4):255-8.
12. Lamichaney R, Sherpa M, Das D, Bhutia CT, Laishram S. Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases. J Clin Diagn Res. 2017;11(8):EC09-EC11.
13. Kunz A, Blank W, Braun B. De Quervain's subacute thyroiditis -- colour Doppler sonography findings. Ultraschall Med. 2005;26(2):102-6.
14. Slatosky J, Shipton B, Wahba H. Thyroiditis: differential diagnosis and management. Am Fam Physician. 2000 Feb 15;61(4):1047-52, 1054. Erratum in: Am Fam Physician 2000 ;62(2):318.
15. Stasiak M, Lewiński A. New aspects in the pathogenesis and management of subacute thyroiditis. Rev Endocr Metab Disord. 2021 ;22(4):1027-1039.
16. Sow DS, Mariko M , Traoré D et al. Les Thyroïdites à l’Hôpital du Mali : Aspects Diagnostiques, Thérapeutiques et Évolutifs. Health Sci. Dis. 2021 ; 22 (9): 35-38
17. Stancek D, Ciampor F, Mucha V, Hnilica P, Stancekova M. Morphological, cytological and biological observations on viruses isolated from patients with subacute thyroiditis de Quervain. Acta Virol. 1976 ;20(3):183-8
18. Angel M, Cano JF, del Olmo A, Rives A, Balcells A. Sarcoidosis, adenoma tóxico de tiroides y tiroiditis de De Quervain : asociación o coincidencia? [Sarcoidosis, toxic thyroid adenoma, and De Quervain's thyroiditis. Association or coincidence (author's transl)]. Med Clin (Barc). 1979 ;72(9):384-7