Evaluation de la prise en charge des cancers chez les enfants infectés par le VIH au CME/FCB et à l'hôpital Général de Yaoundé

NKOA MBALLA Guichèlle fernande
Pediatrics, Institut Supérieur de technologie médicale de Yaoundé
September, 2015
 

Abstract

The aim of our study was to describe the different cancers found in patients with HIV and to evaluate their response to treatment on an exhaustive population. We carried out a retrospective study of cancer cases in children infected with HIV,diagnosed in hemato-oncology unit of the CME-FCB and oncology unit of the Yaounde General Hospital from January 2007 to December 2014.These cancers were registered as malignant tumors in children.We analyzed their clinical and anatomopathological characteristics,treatment modalities,evolution and prognostics factors. Fifteen children were included with a mid-age of 6.5yrs.We identified 9 cases(60%) of non hodgkin's lymphoma and 6 cases of Kaposi Sarcoma(40%).On a total of 13children, cancer workups permitted the discovery of an HIV infection in 6(46,2%).A treatment aiming at curing was administeredto 15 patients but 4 dropped out before the start of chemotherapy and 3 during chemotherapy.The global survival was 70%.In univariate analysis, the expansion stage of cancer at diagnosis is a prognostic factor. The Kaposi sarcoma and lymphoma are the most frequent cancers in childreninfected with HIV.Lymphomas are more frequent than the Kaposi sarcoma.These children have a good tolerance to chemotherapy


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