Spheno-Sellar Chordoma in a Female Elderly Diabetics : a Case Report
Chordome Sphéno-Sellaire chez une Diabétique Âgée : À Propos d’un Cas
DOI:
https://doi.org/10.5281/hra.v3i2.6365Keywords:
Chordoma, skull base, Chu d'AngréAbstract
RÉSUMÉ Nous rapportons le cas d’une patiente de 74 ans, diabétique, hypertendue, ayant des antécédents d'AVC ischémique et d'opération pour glaucome, admise en réanimation pour un trouble de la conscience insidieux. L'examen clinique a révélé un coma modéré (score de Glasgow à 10/15) sans déficit moteur ni convulsions. Les imageries (CT et IRM) ont montré un chordome sphéno-sellaire hypervascularisé et hémorragique, avec extension extradurale aux gyri frontaux et des lésions secondaires nodulaires frontales associées à un œdème cérébral frontal. Le traitement a été palliatif, incluant la réanimation hydroélectrolytique, la réhabilitation nutritionnelle et la prévention des complications de décubitus. La patiente est décédée après 8 jours de réanimation, en raison de la détérioration neurologique et d'une détresse respiratoire hypoxique. ABSTRACT We report the case of a 74-year-old female patient with a history of diabetes, hypertension, ischemic stroke, and glaucoma surgery, who was admitted to the intensive care unit due to an insidious onset of altered consciousness. Clinical examination revealed a moderate coma (Glasgow Coma Scale score of 10/15) without any motor deficits or seizures. Imaging studies (CT and MRI) revealed a hypervascular and hemorrhagic spheno-sellar chordoma, with extradural extension to the frontal gyri and secondary nodular frontal lesions, accompanied by frontal cerebral edema. Treatment was palliative, consisting of hydro-electrolytic resuscitation, nutritional support, and prevention of pressure ulcers. The patient succumbed after 8 days of intensive care due to neurological deterioration and hypoxic respiratory failure.References
1. Dahlin DC, MacCarty CS. Chordoma. Cancer. 1952;5(6):1170–1178
2. CDM F, JA B, PCW H, F M. WHO Classification of Tumours of Soft Tissue and Bone [Internet]. [cited 2021 Apr 21]. Available from: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/WHO-Classification-Of-Tumours-Of-Soft-Tissue-And-Bone-2013
3. McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control. 2001 Jan;12(1):1–11.
4. Champeaux K, San-Galli F, Eimer S, Liguoro D. Métastase radiculaire d’un chordome secondaire à une dissémination dans le liquide cérébrospinal. Neurochirurgie. 1 février 2008 ; 54 (1) :41‑5.
5. Hug EB, Loredo LN, Slater JD, DeVries A, Grove RI, Schaefer RA, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 1999;91:432–9.
6. Frezza AM, Botta L, Trama A, Dei Tos AP, Stacchiotti S. Chordoma: update on disease, epidemiology, biology and medical therapies. Curr Opin Oncol. Mars 2019;31(2):114‑20.
7. Masson E. EM-Consulte. [cité le 26 mai 2024]. Les chordomes. Disponible sur : https://www.em-consulte.com/article/903994/les-chordomes
8. Moukhlissi M, Sghier AB, Bensaid M, Mezouar L. Le chordome sacrococcygien: à propos d’un cas.
9. Siyouri O, Ismaili KA, Stitou I, Ismaili M, Medyouni H, Chouef J, et al. Pre-Sacral Chordomas, about Two Cases and Review of the Literature. JCT. 2023 ;14(04) :152‑60.
10. Locquet MA. Validation de modèles 3D de chordome et preuves de concept in vitro d’une stratégie radiosensibilisante.
11. Brada M, Pijls-Johannesma M, Ruysscher DD. Proton Therapy in Clinical Practice: Current Clinical Evidence Journal of Clinical Oncology [Internet]. 21 sept 2016 [cité le 26 mai 2024] ; disponible sur : https://ascopubs.org/doi/10.1200/JCO.2006.10.0131.
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