Phyllodes Tumors of the Breast in Douala: Clinical and Histological Variants
Les Tumeurs Phyllodes du Sein à Douala : Variantes Cliniques et Histologiques
Abstract
RÉSUMÉ
Les tumeurs phyllodes du sein sont des pathologies rares, représentant 0,3-1% des tumeurs du sein. Nous rapportons quatre cas sur 217 tumeurs du sein analysées histologiquement entre 2020 et 2023 à l’hôpital gynéco obstétrique et pédiatrique de Douala. L’âge de nos patientes était compris entre 24 et 59 ans avec une médiane de 36 ans. Trois tumeurs sur 4 étaient des tumeurs géantes, la prise en charge a été chirurgicale dans tous les cas. Une tumeur sur quatre s’est avérée maligne. Cette série de cas met en exergue la réalité de la tumeur phyllode dans notre milieu ainsi que ce qui semble être une particularité africaine : l’âge plus jeune au diagnostic et l’aspect clinique prépondérant de tumeur géante. Des études exhaustives devraient être réalisées pour vérifier cette assertion.
ABSTRACT
Phyllodes tumors of the breast are rare conditions, representing 0.3-1% of breast tumors. We reported four cases out of 217 breast tumors histologically analyzed between 2020 and 2023 at the Gynecology, Obstetrics, and Pediatric Hospital of Douala. The age of our patients ranged from 24 to 59 years, with a median of 36 years. Three out of four tumors were giant tumors, and all cases were managed surgically. One out of four tumors was malignant. This case series highlights the presence of phyllodes tumors in our setting and a potential African parculiarity: a younger age at diagnosis and a predominant clinical presentation of giant tumors. However, comprehensive studies should be conducted to verify this assertion.
References
Kamal MZ, Banu NR, Alam MM, Das UK, Karmoker RK. Evaluation of Breast Lump - Comparison between True-cut Needle Biopsy and FNAC in MMCH: A Study of 100 Cases. Mymensingh Med J. 2020 Jan;29(1):48-54.
Sancho-Garnier H, Colonna M. Epidémiologie des cancers du sein. Breast cancer epidemiology. La presse médicale. 2019; 48(10): 1076-1084.https://doi.org/10.1016/j.lpm.2019.09.022
Sinn HP, Kreipe H. A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition. Breast Care (Basel). 2013 May;8(2):149-54. Doi: 10.1159/000350774.
Agarwal I, Blanco L. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastmalignantwhoclassification.html.
Li JJX, Tse GM. Phyllodes tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastphyllodesgeneral.html.
Mishra SP, Tiwary SK, Mishra M, Khanna AK. Phyllodes tumor of breast: a review article. ISRN Surg. 2013;2013:361469. doi: 10.1155/2013/361469.
B.S. DIALLO, B.A. DIALLO, A. SYLLA, I. CONtE, A. DIALLO, Y. DIALLO, m.K. DIALLO, I.S. BALDE, m. KOuLIBALY, t.SY, Y. HYJAZI, N. KEItA tumeurs phyllodes du sein : fréquence et aspects anatomo-cliniques au CHu de Conakry (guinée) Journal de la SAGO, 2020, vol.21, n°1, p.50-54. https://jsago.org/index.php/jsago/article/view/67
Alkushi A, Arabi H, Al-riyees L et al. Phyllods tumor of the breast clinical experience and outcomes: a retrospective cohort tertiary hospital experience. Ann Diag Path 2021 april 151702 https://doi.org/10.1016/j.anndiagpath.2021.151702
Chougule A, Bal A, Rastogi P, Das A. Recurrent phyllodes tumor in the male breast in a background of gynaecomastia. Breast Dis. 2015;35(2):139-42. doi: 10.3233/BD-140393. PMID: 25425572.
Mustață L, Gică N, Botezatu R, Chirculescu R, Gică C, Peltecu G, Panaitescu AM. Malignant Phyllodes Tumor of the Breast and Pregnancy: A Rare Case Report and Literature Review. Medicina (Kaunas). 2021 Dec 26;58(1):36. doi: 10.3390/medicina58010036. PMID: 35056344; PMCID: PMC8780966.
Bernstein L, Deapen D, Ross RK. The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast. Cancer. 1993 May 15;71(10):3020-4. doi: 10.1002/1097-0142(19930515)71:10<3020::aid-cncr2820711022>3.0.co;2-g. PMID: 8387873.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene. 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785.
Hasdemir S, Tolunay Ş, Özşen M, Gökgöz MŞ. Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases. Eur J Breast Health. 2019 Oct 3;16(1):32-38. doi: 10.5152/ejbh.2019.4709. PMID: 31912011; PMCID: PMC6939715.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH. Phyllodes tumours of the breast: a consensus review. Histopathology. 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026; PMCID: PMC5027876.
Hashmi AA, Mallick BA, Rashid K, Zafar S, Zia S, Malik UA, Sapna F, Anjali F, Vishal F, Irfan M. Clinicopathological Parameters Predicting Malignancy in Phyllodes Tumor of the Breast. Cureus. 2023 Sep 28;15(9):e46168. doi: 10.7759/cureus.46168. PMID: 37908929; PMCID: PMC10613785.
Bendiifallah S, Canelorbe G. prise en charge des tumeurs bénignes du sein épidémiologiquement fréquentes de type adénofibrome, phyllode grade 1&2, et papillome: recommandations. Journal de Gyne ́cologie Obste ́trique et Biologie de la Reproduction (2015) 44, 1017—1029 . http://dx.doi.org/10.1016/j.jgyn.2015.09.042
Reinfuss M, Mituś J, Duda K, Stelmach A, Ryś J, Smolak K. The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases. Cancer. 1996 Mar 1;77(5):910-6. doi: 10.1002/(sici)1097-0142(19960301)77:5<910::aid-cncr16>3.0.co;2-6. PMID: 8608483.
Kaikai IA, Bourhafour M, Haffadi M, Bouchbika Z, Benchakroune N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A. Quelle chimiothérapie dans les tumeurs phyllodes métastatiques du sein? rapport de cas [Which chemotherapy regimen in patients with metastatic phyllodes tumors of the breast? case report]. Pan Afr Med J. 2022 Aug 18;42:293. French. doi: 10.11604/pamj.2022.42.293.20377. PMID: 36415336; PMCID: PMC9643797.
Abe H, Teramoto A, Takei Y, Tanaka Y, Yoneda G. Malignant phyllodes tumor of the breast with rapid progression: a case report. Surg Case Rep. 2020 Dec 7;6(1):308. doi: 10.1186/s40792-020-00986-8. PMID: 33284362; PMCID: PMC7721958.
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Copyright (c) 2024 Kamdem Modjo Diane Estelle, Alima Jean Marie, Neng Tatah Humphry, Ngo Ndingom Madye, Fouogue Tsuala Jiovanny, Bilkissou Moustapha, Bilkissou Moustapha, Ngalame Alphonse, Atangana Paul Adrien, Atangana Paul Adrien, Kenfack Bruno, Kenfack Bruno, Kenfack Bruno, Mboudou Emile Telesphors
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