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Abstract
Introduction. Primary malignant tumors of the limbs are rare conditions. They are most common in children and adolescents. Treatment is long and costly, and requires long-term follow-up. Our aim was to describe the clinical and paraclinical results of their management in Bouake. Materials and methods. This was a cross-sectional study conducted over 8 years (January 2011 to December 2018) at the traumatology and orthopedics department of the Bouaké University Hospital. It concerned patients treated and followed up for at least 5 years for malignant tumors of the limbs. Our variables of study were sociodemographic, diagnostic, therapeutic and evolutionary. Results. Twenty-six cases were studied. Their mean age was 34.5 years. The sex ratio was 1.17. Most patients lived outside Bouaké (n=17). Tumors predominated in the pelvic limbs (n=15). They were frequent in the leg (n=11). Surgery (n=23) followed by chemotherapy (n=2) and radiotherapy (n=2) were the main therapeutic modalities. Mean theoretical follow-up was 8 years. We had were 7 live patients, 15 lost to follow-up and 4 deaths. The WHO score for living patients was 1. Conclusion. Long-term follow-up of malignant tumors of the limbs is irregular and inadequate in Bouake. Vital prognosis is poor.
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References
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References
-Kone SJ, N’dah KR, Kouakou KA, et al. Primary Malignant Bones Cancers in Côte d’Ivoire: Epidemiological and Histopathological Aspects. Open Journal of Pathology 2018; 8:51-59.
-Canadian Cancer Society. What is bone cancer. Disponible : http://www.cancer.ca/frca/cancer-information/cancer-type/bone/bonecancer/. Consulté le 23 Avril 2019.
-Zomalhèto Z, Biaou O, Yekpe P, Gnankadja SNE, Avimadjè M. Profil des tumeurs osseuses malignes primitives de l’adulte à Cotonou (Benin). J Afr Cancer 2015; 7:100 - 3.
-Berg VHD. Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Ped Orthop 2008; 28(5): 561-4.
- Fletcher C D, Unni KK, Mertens F. Pathology and Genetics of Tumours of Soft Tissue and Bone (2002) (Vol. 4). IARC, Lyon.
-Hawkins DS, Rajendran JG, Conrad EU, Bruckner JD, Eary JF.Evaluation of Chemotherapy Response in Pediatric Bone Sarcomas by [F-18] -fluorodeoxy-D-glucose Positron Emission Tomography. Cancer (2002), 94, 3277-3284.
-Données globales d’épidemiologie des cancers. Institut National du cancer
https://www.e-cancer.fr// consulté le 13/10/2023
- Kouassi KJE, Akobe AJR, Kouassi AAN, Soro ZM, Krah KL, Kodo M. Aspects épidémiologiques et thérapeutiques des ostéosarcomes en milieu tropical. Rev int sc méd 2023;25(1):95-101
-Alexandra K. Primary malignant tumor of the bone. Surgery (Oxford) 2015 ; 33 (1):26-33.
- Dunot J, Ahrens S, Paulussen M, et al. Traitements non chirurgicaux des tumeurs des os: chimiothérapie et radiothérapie. Encycl Méd Chir : appareil locomoteur. 2001; 14 – 702.
-National cancer intelligence network. Bone Sarcomas: incidence and survival rates in England. NCIN Data Briefings; sep 2010.
-Cofer. Tumeur des os primitives et secondaire.5e Edition. Paris : Elsevier-Masson ; octobre 2015. Item 304 UE9. 35-Schubert T, Docquier P, Delloye C. Tumeurs osseuses malignes de l'appareil locomoteur. UCL, 2013 ; 11p.
- Jemal A. Cancer statistics, 2009 CA Cancer J Clin. 2009; 59:225–49
- Farikou I, Motah M, Ngo NB, et al. Prise en charge des tumeurs osseuses au Cameroun. Notre expérience initiale. Health Sci Dis 2011 ;12(2) : 6-
- van den Berg H, Kroon HM, Slaar A .Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration ‘PALGA’ . J Pediatr Orthop 2008; 28:29-35.
- Rajiv R.Treatment of bone tumors .Surg pathol clin 2012 5(1):301-18
-Grimer R. World health organization classification of tumor of soft tissue and bone. Lyon IARC Press 2013 ;6:244-5.
-Baker LH .Soft Tissue and Bone Sarcomas: A disease State Overview The Practicing Oncologist’s Perspective.2010;6:1-6
-Oumar N, Desire M A, Mbaye F, et al. Aspectsépidemiologiques, diagnostiques et thérapeutiques des ostéosarcomes de l’enfant au CHU Aristide le Dantec de Dakar : à propos de 16 cas. Pan African Medical Journal. 2013; 14: 104.
- Peko JF, Gombe-Mbalawa A .Aspects épidémiologiques et anatomopathologiques des cancers primitifs des os à Brazzaville. Mali Méd 2003;18(1):43-4.
- Athanasou N,Bielack S,De Alava E, et al .Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up .Annals of Oncology.2010;21(5): 204–13
-Leavey PJ, Collier AB .Ewing sarcoma: prognostic criteria, outcomes and future treatment. Expert Rev Anticancer Ther 2008(8):617–24
-Visuri TI, Pukkala E, Pulkkinen P, Paavolainen P. Cancer incidence and causes of death among total hip replacement patients: a review based on Nordic cohorts with a special emphasis on metal-on-metal bearings .Proc Inst Mech Eng H 2006;220(2):399-407.
- Yao LB, Akobe AJR, Séry BNJL, M’bra K I et al. Mortalité en Orthopédie-Traumatologie : aspects épidémiologiques et facteurs de risques. Rev int sc méd 2021;23,1:55-62.