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Abstract
RESUME
L’acanthosis nigricans est caractérisée par des lésions papillomateuses velouté localisées dans les plis seulement dans les cas de patients souffrant de diabète sucré les lésions cutanées sont particulières par leur forme et leur siège et leur extension. Nous rapportons un cas de diabète sucré révélé par un acanthosis nigricans bénin chez une patiente non obèse. Il s’agit d’une patiente de 18 ans, sans ATCD notables, reçue en consultation pour lésions cutanées hyper pigmentées, asthénie, amaigrissement. Les examens cliniques et paracliniques ont permis de retenir le diagnostic de diabète sucré révélé par un acanthosis nigricans. Le bilan hormonal a révélé une augmentation de la cortisolémie de 8 heures à 424,2 ng/ml et de la testostérone à 12,4 ng/ml. L’initiation d’antidiabétique oral (biguanide) à base de Metformine 850 mg a permis une évolution favorable avec un équilibre glycémique satisfaisant à 6 mois et une régression progressive des lésions cutanées sur le corps.
ABSTRACT
Acanthosis nigricans is characterised by velvety papillomatous lesions localised in the folds. Only in patients suffering from diabetes mellitus are the cutaneous lesions particular in their shape, location and extension. We report a case of diabetes mellitus revealed by benign acanthosis nigricans in a non-obese patient. The patient was 18 years old with no previous history of diabetes mellitus and presented with hyperpigmented skin lesions, asthenia and weight loss. Clinical and paraclinical examinations led to the diagnosis of diabetes mellitus revealed by acanthosis nigricans. Hormonal tests revealed an increase in 8-hour cortisol levels to 424.2 ng/ml and testosterone to 12.4 ng/ml.Initiation of an oral antidiabetic (biguanide) based on Metformin 850 mg resulted in a favourable outcome with satisfactory glycaemic control at 6 months and progressive regression of the skin lesions on the body.
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References
- - Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, et al. The syndromes of insulin resistance and acanthosis nigricans: insulin receptor disorders in man. N Engl J Med 1976; 294:739-45.
- - De Schepper S., Naeyaert J.-M.Acanthosis nigricans. EMC- Dermatologie 2006 40(2):17.
- - Phiske, Meghana Madhukar. An approach to acanthosis nigricans. Indian Dermatology Online Journal 2014; 5(3): 239-249.
- - Joseph A. Hud Jr, MD; Jack B. Cohen, MD; James M. Wagner, MD; et al. Prevalence and Significance of Acanthosis Nigricans in an Adult Obese Population. Arch Dermatol. 1992;128(7):941-944
- - Curth HO. The necessity of distinguishing four types of acanthosis nigricans. In: Jadassohn W, Schirren CG, editors. XIII Congressus Internationalis Dermatologiae 31.7-5.8. 1967. Berlin: Springer-Verlag; 1968. p. 557-8.
- - Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, MartinMM, et al. The syndromes of insulin resistance and acanthosis nigricans: insulin receptor disorders in man. N Engl J Med 1976; 294:739-45.
- - Cruz PD, Hud JA. Excess insulin binding to insulin-like growth factor receptors: proposed mechanism for acanthosis nigricans. J Invest Dermatol 1992; 98(suppl6):82S-85S.
- - Rogers DL. Acanthosis nigricans. Semin Dermatol 1991; 10:160-3.
- - Torley D, Bellus GA, Munro CS. Genes, growth factors and acanthosis nigricans. Br J Dermatol 2002; 147:1096-101.
- - Hernández-Pérez E: On the classification of acanthosis nigricans. Int J Dermatol. 1984(23): 605-606.
- - Curth HO: Classification of acanthosis nigricans. Int J Dermatol 15: 592-593, 1976.
- - Burke JP, Hale DE, Hazuda HP and Stern MP: A quantitative scale of acanthosis nigricans. Diabetes Care. 1999(22): 1655-1659.
- - Sinha S and Schwartz RA: Juvenile acanthosis nigricans. J Am Acad Dermatol 57: 502-508, 2007.
- - Maria-Linda Popal, Adrian Claudiu Popa, Cristiana Tanase And Ancuta-Augustina Gheorghisan-Galateanu. Acanthosis nigricans: To be or not to be afraid (Review). Oncology letters. 2019(17): 4133-4138.
- - Giri D, Alsaffar H and Ramakrishnan R: Acanthosis nigricans and its response to metformin. Pediatr Dermatol 34: e281-e282, 2017.
References
- Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, et al. The syndromes of insulin resistance and acanthosis nigricans: insulin receptor disorders in man. N Engl J Med 1976; 294:739-45.
- De Schepper S., Naeyaert J.-M.Acanthosis nigricans. EMC- Dermatologie 2006 40(2):17.
- Phiske, Meghana Madhukar. An approach to acanthosis nigricans. Indian Dermatology Online Journal 2014; 5(3): 239-249.
- Joseph A. Hud Jr, MD; Jack B. Cohen, MD; James M. Wagner, MD; et al. Prevalence and Significance of Acanthosis Nigricans in an Adult Obese Population. Arch Dermatol. 1992;128(7):941-944
- Curth HO. The necessity of distinguishing four types of acanthosis nigricans. In: Jadassohn W, Schirren CG, editors. XIII Congressus Internationalis Dermatologiae 31.7-5.8. 1967. Berlin: Springer-Verlag; 1968. p. 557-8.
- Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, MartinMM, et al. The syndromes of insulin resistance and acanthosis nigricans: insulin receptor disorders in man. N Engl J Med 1976; 294:739-45.
- Cruz PD, Hud JA. Excess insulin binding to insulin-like growth factor receptors: proposed mechanism for acanthosis nigricans. J Invest Dermatol 1992; 98(suppl6):82S-85S.
- Rogers DL. Acanthosis nigricans. Semin Dermatol 1991; 10:160-3.
- Torley D, Bellus GA, Munro CS. Genes, growth factors and acanthosis nigricans. Br J Dermatol 2002; 147:1096-101.
- Hernández-Pérez E: On the classification of acanthosis nigricans. Int J Dermatol. 1984(23): 605-606.
- Curth HO: Classification of acanthosis nigricans. Int J Dermatol 15: 592-593, 1976.
- Burke JP, Hale DE, Hazuda HP and Stern MP: A quantitative scale of acanthosis nigricans. Diabetes Care. 1999(22): 1655-1659.
- Sinha S and Schwartz RA: Juvenile acanthosis nigricans. J Am Acad Dermatol 57: 502-508, 2007.
- Maria-Linda Popal, Adrian Claudiu Popa, Cristiana Tanase And Ancuta-Augustina Gheorghisan-Galateanu. Acanthosis nigricans: To be or not to be afraid (Review). Oncology letters. 2019(17): 4133-4138.
- Giri D, Alsaffar H and Ramakrishnan R: Acanthosis nigricans and its response to metformin. Pediatr Dermatol 34: e281-e282, 2017.