MANAGEMENT OF DUALLY ACTIVE CHRONIC HEPATITIS B (HBV) AND HEPATITIS C VIRUS (HCV) CO-INFECTION: CASE REPORT.

Henry Namme Luma, Servais Albert Fiacre Eloumou Bagnaka, Elvis Temfack

Abstract


ABSTRACT

We report the case of a 60 year old gentleman referred for management of dually active chronic hepatitis B (HBV) and C (HCV) co-infection. Initial treatment with Pegylated Interferon and Ribavirin was marked by early virological response for HCV as from week 12 with sustained high virological response to the end of treatment at week 48. There was however a non-response of the HBV to this peg interferon and Ribavirin and the introduction of a nucleoside analogue (Tenofovir) at the end of Peg interferon Ribavirin treatment at week 48 resulted in remarkable HBV suppression to undetectable HBV-DNA levels. While this case report demonstrates that HBV/HCV co-infection can be satisfactorily treated in our setting, the high prevalence of both viral infections in Cameroon, the high cost of management and the unavailability of appropriate drugs warrants the Ministry of Public Health to take the lead in implementing adequate preventive and therapeutic strategies so as to reduce morbidity and mortality of liver diseases associated with these infections.


Keywords


Hepatitis B, Hepatitis C, Co-infection, Interferon, Ribavirin, Tenofovir

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