Prévalence et Déterminants de l’Hyperuricémie chez le Patient Diabétique de Type 2 à Bouaké
Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients in Bouaké
DOI :
https://doi.org/10.5281/hra.v2i7.5657Mots-clés :
hyperuricémie, diabète de type 2, CHU de Bouaké, Côte d’IvoireRésumé
RÉSUMÉ
Introduction. L'hyperuricémie est un facteur de risque indépendant pour le développement du diabète de type 2 et est associée à une augmente de la morbimortalité chez les patients diabétiques. Le but de cette étude était de déterminer la prévalence et les déterminants de l'hyperuricémie chez les patients diabétiques de type 2 suivis au Centre Hospitalier de Bouaké. Méthodes. Il s'agissait d'une étude rétrospective à visée descriptive réalisée sur 6 mois au CHU de Bouaké. L'hyperuricémie a été définie comme un taux d'acide urique sérique >70 mg/l pour les hommes et >60 mg/l pour les femmes. Résultats. Un total de 102 dossiers de patients diabétiques de type 2 au cours du suivi ont été recrutés dans l'étude. La prévalence de l'hyperuricémie était de 29,4% (n=30) dans la population étudiée. L'âge moyen des patients était de 61,5 ± 9,7 ans et le sex-ratio de 0,85. L'indice de masse corporelle (IMC) moyen était de 26,9 ± 6,9 kg/m². La durée moyenne du diabète était de 4,7 ± 6,9 ans et 67,6% des patients souffraient d'hypertension artérielle. L’obésité abdominale retrouvée dans 48% des cas. L’hémoglobine A1c moyenne était de 9,5 ± 3% avec plus des deux tiers des patients qui présentaient un diabète déséquilibré. L’hypertension artérielle systolique et l’hypertriglycéridémie étaient statistiquement associés à l’hyperuricémie, contrairement aux autres variables indépendantes. Conclusion. La prévalence de l'hyperuricémie était relativement élevée chez les patients diabétiques de type 2. L'hyperuricémie était significativement associée à l’hypertension artérielle systolique et l’hypertriglycéridémie.
ABSTRACT
Introduction. Hyperuricemia is an independent risk factor for the development of type 2 diabetes and is associated with increased morbidity and mortality in diabetic patients. The aim of this study was to determine the prevalence and determinants of hyperuricemia in type 2 diabetic patients followed at Bouaké University Hospital Center. Materials and methods. This was a retrospective descriptive study conducted over 6 months at Bouaké University Hospital. Hyperuricaemia was defined as a serum uric acid level >70 mg/l for men and >60 mg/l for women. Results. A total of 102 records of patients with type 2 diabetes during follow-up were enrolled in the study. The prevalence of hyperuricaemia was 29.4% (n=30) in the study population. The mean age of the patients was 61.5 ± 9.7 years and the sex ratio was 0.85. The mean body mass index (BMI) was 26.9 ± 6.9 kg/m². The mean duration of diabetes was 4.7 ± 6.9 years, and 67.6% of patients had arterial hypertension. Abdominal obesity was found in 48% of cases. The mean haemoglobin A1c was 9.5 ± 3%, with more than two-thirds of patients presenting with unbalanced diabetes. Systolic arterial hypertension and hypertriglyceridaemia were statistically associated with hyperuricaemia, unlike the other independent variables. Conclusion. The prevalence of hyperuricaemia was relatively high in type 2 diabetic patients. Hyperuricaemia was significantly associated with systolic hypertension and hypertriglyceridaemia.
Références
Koné F, Kouamé KGR, Acho JK, Yapa GSK, Touré YL, Touré KH et al. Prevalence and Characteristics of Metabolic Syndrome in Elderly Diabetics in Bouaké (Côte d'Ivoire). Health Sci Dis 2024;25: 15-9
Alemayehu E, Fiseha T, Bambo GM, Sahile Kebede S, Bisetegn H, Tilahun M et al. Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis. BMC Endocr Disord 2023;23:153-63
Arersa KK, Wondimnew T, Welde M, Husen TM. Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients Attending Jimma Medical Center, Southwestern Ethiopia, 2019. Diabetes Metab Syndr Obes 2020;13:2059–67
Shi H, Liu Y, Wang J, Luan H, Shi C. Prevalence of hyperuricaemia among adults from Ningxia Hui Autonomous Region, China: a cross-sectional study. BMJ Open 2023;13:72-82
Mortada I. Hyperuricemia, Type 2 Diabetes Mellitus, and Hypertension: an Emerging Association. Curr Hypertens Rep 2017;19:69-74
Rao TMV, Vanukuri NK. A study on serum uric acid levels in type 2 diabetes mellitus and its association with cardiovascular risk factors. IAIM, 2016; 3(12): 148-155.
So A, Thorens B. Uric acid transport and disease. J Clin Invest 2010;120:1791-9
Agarwal A, Singh M, Arya V, Garg U, Pal V, Jain V. Prevalence of peripheral arterial disease in type 2 diabetes mellitus and its correlation with coronary artery disease and its risk factors. The Journal of the Association of Physicians of India 2012;60:28-32
Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024 Diabetes Care 2024;47(Suppl.1):S20–S42
Krishnan E, Akhras KS, Sharma H, Marynchenko M, Wu EQ, Tawk R et al. Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. QJM: An International Journal of Medicine 2013;106:721-9
Jiao Wang, Rong-Ping Chen, Lei Lei, Qing-Qing Song, Ru-Yi Zhang, Yan-Bing Li, et al. Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients with Central Obesity in Guangdong Province in China. Asia Pacific Journal of Clinical Nutrition 2013;22:4-16
Shah P, Bjornstad P, Johnson RJ. Hyperuricemia as a potential risk factor for type 2 diabetes and diabetic nephropathy. Braz J Nephrol 2016;38:386-7
Woyesa SB, Hirigo AT, Wube TB. Hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients at Hawassa university comprehensive specialized hospital, South West Ethiopia. BMC Endocr Disord 2017;17:76-86
Ogbera AO, Azenabor AO. Hyperuricaemia and the metabolic syndrome in type 2 DM. Diabetol Metab Syndr 2010;2:24-32
Mundhe S, Mhasde D. The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus. Int J Adv Med 2016:241-9
Sakiyama M, Matsuo H, Takada Y, Nakamura T, Nakayama A, Takada T et al. Ethnic Differences in ATP-binding Cassette Transporter, Sub-family G, Member 2 (ABCG2/BCRP): Genotype Combinations and Estimated Functions. Drug Metabolism and Pharmacokinetics 2014;29:490-2
Woldeamlak B, Yirdaw K, Biadgo B. Hyperuricemia and its Association with Cardiovascular Disease Risk Factors in Type Two Diabetes Mellitus Patients at the University of Gondar Hospital, Northwest Ethiopia. EJIFCC 2019;30:325-39
Doualla M, Nkeck JR, Halle MP, Felicité K, Agouak AI, Essouma M. Hyperuricemia in chronic hemodialysis in Douala. Health Res. Afr 2023; 1 (1) : 17-24
Jurado J, Ybarra J, Solanas P, Caula J, Gich I, Pou JM et al. Prevalence of cardiovascular disease and risk factors in a type 2 diabetic population of the North Catalonia diabetes study. Journal of the American Association of Nurse Practitioners 2009;21:140-8
Conen D, Wietlisbach V, Bovet P, Shamlaye C, Riesen W, Paccaud F, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health 2004;4:9-18
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(c) Tous droits réservés Famoussa Kone, Kadidiata Hamed Touré, Lauret Kouassi, Jean Kévin Acho, Gnadou Stéphane Kény Yapa, Bansimba Stéphane Rodney Nzonzy, Oumar Naponon Keita, Salifou Koné, Bourhaima Ouattara 2024
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