Main Article Content
Abstract
RÉSUMÉ
Dans les pays technologiquement avancés, les tumeurs cérébrales ont vu leur diagnostic et traitement nettement évolué par le développement de nouvelles techniques d’imagerie (IRM, PET, SPECT…) et les innovations thérapeutiques. Mais les tumeurs cérébrales engagent dans une large mesure le pronostic vital des patients à moyen et long terme. La morbidité et la mortalité de ces tumeurs étant considérables, leur impact sur le système de santé est disproportionné par rapport à leur incidence annuelle. Les tumeurs cérébrales représentaient 1,4 % de tous les nouveaux cas de cancers et 2,4 % de tous les décès par cancer [1]. Nous avons mené une étude prospective et descriptive dans le service de neurologie du CHU Point G du 1er Janvier 2019 au 31 Mars 2020. Nous avons trouvé une fréquence de 2,7%, le sexe féminin était le plus représenté avec un sex-ratio 0,66. Dans quarante-cinq pourcent des cas, les patients venaient du domicile pour la consultation et dans 20% des cas du service d’Accueil des Urgences. Le déficit moteur était le motif d’hospitalisation le plus représenté soit 50%. La localisation des TC était sus tentorielle chez 80%. La mortalité était de 55%. Une prise en charge pluridisciplinaire permettra de répondre aux multiples écueils que pose cette entité de pronostic parfois sombre.
ABSTRACT
In technologycally advanced countries, the diagnosis and treatment of brain tumors have significantly evolved through the development of new imaging techniques (MRI, PET, SPECT, etc.) and therapeutic innovations. But brain tumors are to a large extent life-threatening for patients in the medium and long term. The morbidity and mortality of these tumors being considerable, their impact on the health system is disproportionate to their annual incidence. Brain tumors accounted for 1.4% of all new cancer cases and 2.4% of all cancer deaths. We conducted a prospective and descriptive study in the neurology department of CHU Point G from January 1, 2019 to March 31, 2020. We found a frequency of 2.7%, the female sex was the most represented with a sex ratio of 0 .66. In forty-five percent of cases, patients came from home for the consultation and in 20% of cases from the Emergency Department. Motor deficit was the most common reason for hospitalization, i.e. 50%. TC localization was supratentorial in 80%. Mortality was 55%. Multidisciplinary management will permit to respond to the multiple pitfalls posed by this disease with a sometimes bleak prognosis.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- Perkins A, Liu G. Primary Brain Tumors in Adults: Diagnosis and Treatment . Am Fam Physician. 2016; 93(3):211-7.
- Pouchieu C, Baldi I, Gruber A et al. Descriptive epidemiology and risk factors of primary central nervous system tumors: Current knowledge. Rev Neurol (Paris) 2016;172(1):46-55.
- Ostrom QT, Gittleman H, Xu J et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013. Neuro Oncol 2016;18(suppl_5):v1-v75.
- https://braintumourregistry.ca/wp-content/uploads/2021/05/Incidence-and-Mortality-Report-2021-02-01_fre-CA-Review-Final-to-RA-1.pdf Consulté le 23/03/22
- Louis DN, Perry A, Reifenberger G et al. The 2016 world health organization classification of tumors of the central Nervous system: a summary. Acta Neuropathol 2016;131(6):803-20.
- Bauchet L. Épidémiologie des tumeurs cérébrales primitives. La Lettre du Neurologue 2018 Vol. XXII - n° 5 : 124-9.
- Eckstrand, A.C. CNS Tumours : Exploring Barriers to Registration and Feasibility of Extracting Molecular Characteristics, 2018, mémoire de maîtrise, Université de l’Alberta
- Samudra, N. et coll. Seizures in glioma patients : An overview of incidence, etiology, and therapies. Journal of the neurological sciences, 2019, 404, p. 80-5.
- https://www.arcagy.org/infocancer/localisations/autres-types-de-cancers/tumeurs-cerebrales/maladie/l-epidemiologie.html.
- Howlader N, et al. SEER cancer statistics review, 1975-2012. http://seer. cancer.gov/csr/1975_2012. Pub :2015.
- Cote DJ, Ostrom QT, Gittleman H, Duncan KR, CreveCoeur TS, Kruchko C, Smith TR, Stampfer MJ, Barnholtz-Sloan JS. Glioma incidence and survival variations by county-level socioeconomic measures. Cancer. 2019;125(19):3390–400. Epub 2019/06/18. https://doi.org/10.1002/cncr.32328.
- Porter AB, Lachance DH, Johnson DR. Socioeconomic status and glioblastoma risk: a population-based analysis. Cancer causes & control : CCC. 2015;26(2):179–85. https://doi.org/10.1007/s10552-014-0496-x.
- Darlix A, Zouaoui S, Rigau V et al. Epidemiology for primary brain tumors: a nationwide population-based study. J Neurooncol 2017;131(3):525-46.
- https://www.medicongres.net/download/anocef/diu_si/diu_si1_1_bauchet. pdf Consulté le 23/03/2022.
- Ostrom QT, Patil N, Ciof G, Waite K, Kruchko C, BarnholtzSloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro-oncology. 2020;22(12 Suppl 2):iv1-iv96.
- Meskini M. La prise en charge des tumeurs cérébrales au service de neurochirurgie CHR Agadir : contraintes et perspectives. Thèse Med Marrakech : 2020 : 135 ;143p.
- Klein M. Treatment options and neurocognitive outcome in patients with diffuse low-grade glioma. J Neurosurg Sci 2015 ; 59 : 383-92.
- El Matlini A. Prise en charge des tumeurs cérébrales chez les sujets de plus de 70 ans : expérience du service de neurochirurgie de l’hôpital Arrazi. Thèse Fac Marakech 2019 : 140 p.
- Camara M et al. Place du scanner dans la prise en charge des métastases cérébrales au Centre Hospitalier Mère Enfant « Luxembourg ». HSD 2021, vol.22 ; pp :60-5.
- Natukka, T. et coll. Incidence trends of adult malignant brain tumors in Finland, 1990–2016, Acta Oncologica, 2019, 58 (7), p. 990-6.
- Hazmiri FE, Boukis F, Benali SA, et al. Tumeurs cérébrales de l’enfant : à-propos 136 cas. Pan African Medical Journal. 2018; 30:291 doi:10.11604/pamj.2018.30.291.13208.
- Lu Q, Dai D, Zhao W, et al. Association between MTHFR 677C>T polymorphism and risk of gliomas. Tumour Biol. 2013;34(5):2801-7.
- Zhang H, Liu H, Knauss JL. Associations between three XRCC1 polymorphisms and glioma risk. Tumour Biol. 2013;34(5): 3003-13.
- Wang SS, Bandopadhayay P, Jenkins MR. Towards Immunotherapy for Pediatric Brain Tumors. Trends in Immunology, August 2019, Vol. 40, No. 8 : 748-62.
- Wolchok, J.D. et al. (2017) Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 377, 1345–56.
- Maude, S.L. et al. Sustained remissions with CD19- specific chimeric antigen receptor (CAR)-modified T cells in children with relapsed/refractory ALL. J. Clin. Oncol.2016 34, 3011.
References
Perkins A, Liu G. Primary Brain Tumors in Adults: Diagnosis and Treatment . Am Fam Physician. 2016; 93(3):211-7.
Pouchieu C, Baldi I, Gruber A et al. Descriptive epidemiology and risk factors of primary central nervous system tumors: Current knowledge. Rev Neurol (Paris) 2016;172(1):46-55.
Ostrom QT, Gittleman H, Xu J et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013. Neuro Oncol 2016;18(suppl_5):v1-v75.
https://braintumourregistry.ca/wp-content/uploads/2021/05/Incidence-and-Mortality-Report-2021-02-01_fre-CA-Review-Final-to-RA-1.pdf Consulté le 23/03/22
Louis DN, Perry A, Reifenberger G et al. The 2016 world health organization classification of tumors of the central Nervous system: a summary. Acta Neuropathol 2016;131(6):803-20.
Bauchet L. Épidémiologie des tumeurs cérébrales primitives. La Lettre du Neurologue 2018 Vol. XXII - n° 5 : 124-9.
Eckstrand, A.C. CNS Tumours : Exploring Barriers to Registration and Feasibility of Extracting Molecular Characteristics, 2018, mémoire de maîtrise, Université de l’Alberta
Samudra, N. et coll. Seizures in glioma patients : An overview of incidence, etiology, and therapies. Journal of the neurological sciences, 2019, 404, p. 80-5.
Howlader N, et al. SEER cancer statistics review, 1975-2012. http://seer. cancer.gov/csr/1975_2012. Pub :2015.
Cote DJ, Ostrom QT, Gittleman H, Duncan KR, CreveCoeur TS, Kruchko C, Smith TR, Stampfer MJ, Barnholtz-Sloan JS. Glioma incidence and survival variations by county-level socioeconomic measures. Cancer. 2019;125(19):3390–400. Epub 2019/06/18. https://doi.org/10.1002/cncr.32328.
Porter AB, Lachance DH, Johnson DR. Socioeconomic status and glioblastoma risk: a population-based analysis. Cancer causes & control : CCC. 2015;26(2):179–85. https://doi.org/10.1007/s10552-014-0496-x.
Darlix A, Zouaoui S, Rigau V et al. Epidemiology for primary brain tumors: a nationwide population-based study. J Neurooncol 2017;131(3):525-46.
https://www.medicongres.net/download/anocef/diu_si/diu_si1_1_bauchet. pdf Consulté le 23/03/2022.
Ostrom QT, Patil N, Ciof G, Waite K, Kruchko C, BarnholtzSloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro-oncology. 2020;22(12 Suppl 2):iv1-iv96.
Meskini M. La prise en charge des tumeurs cérébrales au service de neurochirurgie CHR Agadir : contraintes et perspectives. Thèse Med Marrakech : 2020 : 135 ;143p.
Klein M. Treatment options and neurocognitive outcome in patients with diffuse low-grade glioma. J Neurosurg Sci 2015 ; 59 : 383-92.
El Matlini A. Prise en charge des tumeurs cérébrales chez les sujets de plus de 70 ans : expérience du service de neurochirurgie de l’hôpital Arrazi. Thèse Fac Marakech 2019 : 140 p.
Camara M et al. Place du scanner dans la prise en charge des métastases cérébrales au Centre Hospitalier Mère Enfant « Luxembourg ». HSD 2021, vol.22 ; pp :60-5.
Natukka, T. et coll. Incidence trends of adult malignant brain tumors in Finland, 1990–2016, Acta Oncologica, 2019, 58 (7), p. 990-6.
Hazmiri FE, Boukis F, Benali SA, et al. Tumeurs cérébrales de l’enfant : à-propos 136 cas. Pan African Medical Journal. 2018; 30:291 doi:10.11604/pamj.2018.30.291.13208.
Lu Q, Dai D, Zhao W, et al. Association between MTHFR 677C>T polymorphism and risk of gliomas. Tumour Biol. 2013;34(5):2801-7.
Zhang H, Liu H, Knauss JL. Associations between three XRCC1 polymorphisms and glioma risk. Tumour Biol. 2013;34(5): 3003-13.
Wang SS, Bandopadhayay P, Jenkins MR. Towards Immunotherapy for Pediatric Brain Tumors. Trends in Immunology, August 2019, Vol. 40, No. 8 : 748-62.
Wolchok, J.D. et al. (2017) Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 377, 1345–56.
Maude, S.L. et al. Sustained remissions with CD19- specific chimeric antigen receptor (CAR)-modified T cells in children with relapsed/refractory ALL. J. Clin. Oncol.2016 34, 3011.