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Abstract

RESUME
L’acanthosis nigricans est caractérisée par des lésions papillomateuses velouté localisées dans les plis seulement dans les cas de patients souffrant de diabète sucré les lésions cutanées sont particulières par leur forme et leur siège et leur extension. Nous rapportons un cas de diabète sucré révélé par un acanthosis nigricans bénin chez une patiente non obèse. Il s’agit d’une patiente de 18 ans, sans ATCD notables, reçue en consultation pour lésions cutanées hyper pigmentées, asthénie, amaigrissement. Les examens cliniques et paracliniques ont permis de retenir le diagnostic de diabète sucré révélé par un acanthosis nigricans. Le bilan hormonal a révélé une augmentation de la cortisolémie de 8 heures à 424,2 ng/ml et de la testostérone à 12,4 ng/ml. L’initiation d’antidiabétique oral (biguanide) à base de Metformine 850 mg a permis une évolution favorable avec un équilibre glycémique satisfaisant à 6 mois et une régression progressive des lésions cutanées sur le corps.
ABSTRACT
Acanthosis nigricans is characterised by velvety papillomatous lesions localised in the folds. Only in patients suffering from diabetes mellitus are the cutaneous lesions particular in their shape, location and extension. We report a case of diabetes mellitus revealed by benign acanthosis nigricans in a non-obese patient. The patient was 18 years old with no previous history of diabetes mellitus and presented with hyperpigmented skin lesions, asthenia and weight loss. Clinical and paraclinical examinations led to the diagnosis of diabetes mellitus revealed by acanthosis nigricans. Hormonal tests revealed an increase in 8-hour cortisol levels to 424.2 ng/ml and testosterone to 12.4 ng/ml.Initiation of an oral antidiabetic (biguanide) based on Metformin 850 mg resulted in a favourable outcome with satisfactory glycaemic control at 6 months and progressive regression of the skin lesions on the body.

Keywords

Acanthosis nigricans Diabetes mellitus African Acanthosis nigricans Diabète sucré Africain

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René Bognounou, Bonkoungou Marcellin, Eric Arnaud Sid Yida Diendere, Lassane Zoungrana, Yempabou Sagna, Michel Bouda, Seydou Yameogo, Solo Traoré, Zio Gaël, Aline Yameogo Tonde, Ismaël Diallo, Oumar Guira, & Hervé Tieno. (2024). Acanthosis Nigricans Revealing Diabetes Mellitus in a Teenage Girl: A Case Report: Acanthosis Nigricans Révélateur d’un Diabète Sucré chez une Adolescente : À Propos d’un Cas. HEALTH SCIENCES AND DISEASE, 25(11). https://doi.org/10.5281/hsd.v25i11.6161
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