Interobserver Reproducibility of the Gleason Score and ISUP Grade in Prostate Cancers in Cameroon

Auteurs-es

  • Djapa christelle 1. Faculté de médecine et des Sciences Biomédicales, Université de Yaoundé I
  • Mendimi Nkodo JM 1. Faculté de médecine et des Sciences Biomédicales, Université de Yaoundé I
  • Mekeme Mekeme J 1. Faculté de médecine et des Sciences Biomédicales, Université de Yaoundé I
  • Kabeyene Clarisse 1. Faculté de médecine et des Sciences Biomédicales, Université de Yaoundé I
  • Mbassi Achille 2. Institut supérieur de technologie médicale de Nkolondom
  • Kamadjou Cyril 3. Faculté de médecine et des Sciences pharmaceutiques, Universite de Douala
  • Tchuendem Josephine 4. Hopital Gyneco –obstétrique et pédiatrique, Yaoundé
  • Ndoumba Afouba Alice 5. Faculté de médecine et des Sciences pharmaceutiques, Université de Douala
  • Mout Ngankol 6. Centre Pasteur du Cameroun, Yaoundé
  • Sando Zacharie 1. Faculté de médecine et des Sciences Biomédicales, Université de Yaoundé I

DOI :

https://doi.org/10.5281/hra.v2i3.5353

Mots-clés :

Reproductibilité, score de Gleason, ISUP Grage, Coefficient Kappa

Résumé

RÉSUMÉ
Introduction. Le score de Gleason est le critère pronostique par excellence du cancer de la prostate. Il est impératif qu’il y ait une bonne reproductibilité du score de Gleason afin de permettre une prise en charge optimale des patients. Cependant, une variabilité inter observateurs est décrite dans le monde. Notre objectif était d’évaluer la reproductibilité inter observateurs du score de Gleason et conséquemment du grade ISUP au Cameroun. Méthodologie. Il s’agissait d’une étude transversale analytique sur une durée de 07 mois allant du 1er Février au 31 Juillet 2023. Nous avons sélectionné 182 lames provenant de 53 patients. Ces lames ont été soumises à l’appréciation de 4 pathologistes afin qu’ils déterminent le score de Gleason et le grade ISUP. Les différents résultats ont été analysés à l’aide du logiciel SPSS. Résultats. L’âge moyen des patients était de 72,87 ans. Le taux moyen de PSA était de 128,92 ng/ml variant entre 1 et 1600 ng/ml. La biopsie était le type de prélèvement le plus représenté. Les prélèvements étaient de qualité satisfaisante dans 77,36% des cas, 81,13% étaient accompagnés de renseignements cliniques. Les coefficients kappa combinés du score de Gleason et grade ISUP étaient respectivement de 0,357 et 0,384. Un accord faible entre les pathologistes 1 et 2 ; 1 et 3 ; 2 et 4. Par contre nous avons trouvé un accord fort entre les pathologistes 2 et 3. Conclusion. Il existe un accord faible entre les pathologistes camerounais lors de l’évaluation du score Gleason et du grade ISUP.
ABSTRACT
Introduction. The Gleason score is the gold standard prognostic criteria for prostate cancer. It is crucial to have good reproducibility of the Gleason score in order to provide optimal patient management. However, inter-observer variability has been reported worldwide. Our objective was to evaluate the inter-observer reproducibility of the Gleason score and consequently the ISUP grade in Cameroon. Methodology. This was a cross-sectional analytical study conducted over a period of 7 months from February 1st to July 31st, 2023. We selected 182 slides from 53 patients. These slides were evaluated by 4 pathologists to determine the Gleason score and ISUP grade. The results were analyzed using SPSS software. Results. The mean age of the patients was 72.87 years. The mean PSA level was 128.92 ng/ml, ranging from 1 to 1600 ng/ml. Biopsy was the most common type of sample. The samples were of satisfactory quality in 77.36% of cases, and 81.13% were accompanied by clinical information. The combined kappa coefficients for the Gleason score and ISUP grade were 0.357 and 0.384, respectively. There was poor agreement between pathologists 1 and 2; 1 and 3; and 2 and 4. However, we found strong agreement between pathologists 2 and 3. Conclusion. There is poor agreement among Cameroonian pathologists in evaluating the Gleason score and ISUP grade.

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Publié-e

2024-02-24

Comment citer

Djapa christelle, Mendimi Nkodo JM, Mekeme Mekeme J, Kabeyene Clarisse, Mbassi Achille, Kamadjou Cyril, Tchuendem Josephine, Ndoumba Afouba Alice, Mout Ngankol, & Sando Zacharie. (2024). Interobserver Reproducibility of the Gleason Score and ISUP Grade in Prostate Cancers in Cameroon. HEALTH RESEARCH IN AFRICA, 2(3). https://doi.org/10.5281/hra.v2i3.5353

Numéro

Vol. 2 No. 3 (2024): Health Research in Africa

Rubrique

Articles Originaux

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