Article Sidebar
Main Article Content
Abstract
RÉSUMÉ
La tuberculose localisée au niveau du système nerveux central est rare. Parmi ses manifestations neurologiques, figure la thrombose veineuse cérébrale. Celle-ci se manifeste entre autres par des infarctus veineux cérébraux, parfois accompagnés de phénomènes hémorragiques. Nous rapportons un cas de tuberculose disséminée, évolutive et grave. Ce cas est particulier en raison, d’une part de sa gravité caractérisée par la survenue concomitante de plusieurs infarctus hémorragiques veineux cérébraux au décours du traitement antituberculeux de première ligne, et d’autre part de ses caractéristiques étiologiques (vascularite et méningite probable à Mycobacterium tuberculosis résistant à la rifampicine et à l’isoniazide).
ABSTRACT
Tuberculosis settled in the central nervous system is rare. Among its neurological manifestations, there is cerebral venous thrombosis. This is manifested, among other things, by cerebral venous infarctions, sometimes accompanied by hemorrhagic phenomena. We report a case of disseminated, progressive and severe tuberculosis. This case is particular because of its severity, characterized by the concomitant occurrence of several cerebral venous hemorrhagic infarctions during first-line antituberculosis treatment, and because of its etiological features (vasculitis and probable Mycobacterium tuberculosis meningitis resistant to rifampicin and isoniazid).
Keywords
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- World Health Organization. Global Tuberculosis Report 2019. https://apps.who.int/iris/beatstream/handle/10665/329368/9789241565714-eng.pdf.
- Bemba ELP, Bopaka RG, Moyikoua R, Ossibi-Ibara R, Ebenga-Somboko NB, Toungou SN, Matondot PG, Ossale-Abacka BK, Okemba-Okombi FH, Joseph Mboussa J. Tuberculose pulmonaire à Brazzaville en hospitalisation pneumologique: impact du diagnostic tardif à l’infection au VIH sur les anomalies radiographiques. Pan African Medical Journal 2016; 24: 259. Doi : 10.11604/pamj.2016.24.259.9456
- Okemba-Okombi FH, Biniakounou JB, Bemba ELP, Ossibi-Ibara B, Itoua AC, Illoye-Ayet M, Bopaka RG. État des lieux de la prise en charge de la tuberculose pharmaco- résistante au Congo Brazzaville. Revue des Maladies Respiratoires 2017; 34: A212-A213. Doi: 10.1016/j.rmr.2016.10.505
- Rieder HL, Snider DE Jr, Cauthen GM. Extrapulmonary tuberculosis in the United States. American Review of Respiratory Disease 1990; 141 (2): 347-351. Doi: 10.1164/ajrccm/141.2.347.
- Guenifi W, Boukhrissa H, Gasmi A, Rais M, Ouyahia A, Hachani A, Diab N, Mechakra S, Lacheheb A. Thromboses veineuses cérébrales au cours de la méningo-encéphalite tuberculeuse. Journal des Maladies Vasculaires 2016 ; 41 (3): 210-214. Doi: 10.1016/j.jmv.2016.03.002.
- Mansare ML, Atsa Kouda DC, Diallo IM, Ntenga P, Boubacar S, Gams MD, Ndiaye MM. Thrombose du sinus caverneux : un cas clinique révélant une tuberculose multifocale et revue de la littérature. African Journal of Neurological Sciences 2017; 36 (2): 33-42.
- Hot A, Ninet J. Thromboses veineuses de localisation plus rare. In : Cardiologie et maladies vasculaires. Paris : Elsevier Masson, 2007, pp.1157-1161.
- Fleury O, Sibon I. Tuberculose. In: Alamowitch S, Vahedi K, Touzé E (Eds). In : Causes rares des maladies vasculaires cérébrales. Paris : Doin, 2013, pp.29-49.
- Alliez JR, Balan C, Diallo O, Alliez B. Mal de Pott et paraplégie pottique. African Journal of Neurological Sciences 2006; 25 (2): 50-59.
- Goyal JL, Jain P, Arora R, Dokania P. Ocular manifestations of tuberculosis. Indian Journal of Tuberculosis 2015; 62 (2): 66-73. Doi: 10.1016/j.ijtb.2015.04.004
- Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infectious Diseases 2010; 10 (11): 803-812. Doi: 10.1016/S1473-3099(10)70138-9
- World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis 2011 update.
- https://apps.who.int/iris/beatstream/handle/10665/44597/9789241501583-eng.pdf.
- Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY, American Heart Association Stroke Council and the Council on Epidemiology and Prevention. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011 ; 42 (4): 1158-1192. Doi: 10.1161/STR.0b013e31820a8364
- Boonsarngsuk V, Mangkang K, Santanirand P. Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. Clinical Respiratory Journal 2018 ; 12 (6): 2101-2109. Doi: 10.1111/crj.12779
- Bopaka RG, Okemba Okombi FH, Bemba ELP, Ndinga Essango EB, Ossale-Abacka KB, Koumeka PP, Illoye Ayet M, Atipo-Ibara BI. Prise en Charge de la Tuberculose Multirésistante À Brazzaville. Health Sciences & Disease 2020; 21 (6) : 12-16.
- Veziris N, Robert J. Résistance aux antituberculeux et impasse thérapeutique. Médecine/Sciences (Paris) 2010; 26 (11): 976–980. Doi : 10.1051/medsci/20102611976
- Fiorot Júnior JA, Felício AC, Fukujima MM, Rodrigues CA, Morelli VM, Lourenço DM, Prado GF. Tuberculosis: an uncommon cause of cerebral venous thrombosis? Arquivos de Neuro-Psiquiatria 2005; 63 (3B): 852-854. Doi: 10.1590/s0004-282x2005000500025
- Di Roio C, Jourdan C, Yilmaz H, Artru F. Thrombose des veines cérébrales profondes: trois observations [Cerebral deep vein thrombosis: three cases]. Revue Neurologique 1999; 155 (8): 583-587.
- Nagai M, Terao S, Yilmaz G, Yilmaz CE, Esmon CT, Watanabe E, Granger DN. Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis. Stroke 2010; 41 (1): 147-152. Doi: 10.1161/STROKEAHA.109.562983
- Chen C, Wang Q, Gao Y, Lu Z, Cui X, Zheng T, Liu Y, Li X, He X, Zhang X, Duan C, Li T. Photothrombosis combined with thrombin injection establishes a rat model of cerebral venous sinus thrombosis. Neuroscience 2015; 306: 39-49. Doi: 10.1016/j.neuroscience.2015.08.020
- Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Brain Research 2018; 1699: 54-68. Doi: 10.1016/j.brainres.2018.06.029
- Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, Chai H, Ding X, Wang Q. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochemistry International 2020; 141: 104856. Doi: 10.1016/j.neuint.2020.104856
- Hu S, Lee H, Zhao H, Ding Y, Duan J. Inflammation and Severe Cerebral Venous Thrombosis. Frontiers in Neurology 2022; 13: 873802. Doi: 10.3389/fneur.2022.873802
- Ahui BJM, Horo K, Brou-Gode VC, Kouassi AB, Demine B, Anon JC, Motsebo SF, Bemba EL, AchI VH, N’gom AS, Koffi NB, Kendja K, Aka-Danguy E. Apport du traitement chirurgical de la tuberculose à bacilles résistants au cours du suivi médical (expérience du service de pneumologie du CHU de Cocody : à propos de cinq observations). Revue de Pneumologie Clinique 2011; 67(3): 170-173. Doi : 10.1016/j.pneumo.2010.11.004
References
World Health Organization. Global Tuberculosis Report 2019. https://apps.who.int/iris/beatstream/handle/10665/329368/9789241565714-eng.pdf.
Bemba ELP, Bopaka RG, Moyikoua R, Ossibi-Ibara R, Ebenga-Somboko NB, Toungou SN, Matondot PG, Ossale-Abacka BK, Okemba-Okombi FH, Joseph Mboussa J. Tuberculose pulmonaire à Brazzaville en hospitalisation pneumologique: impact du diagnostic tardif à l’infection au VIH sur les anomalies radiographiques. Pan African Medical Journal 2016; 24: 259. Doi : 10.11604/pamj.2016.24.259.9456
Okemba-Okombi FH, Biniakounou JB, Bemba ELP, Ossibi-Ibara B, Itoua AC, Illoye-Ayet M, Bopaka RG. État des lieux de la prise en charge de la tuberculose pharmaco- résistante au Congo Brazzaville. Revue des Maladies Respiratoires 2017; 34: A212-A213. Doi: 10.1016/j.rmr.2016.10.505
Rieder HL, Snider DE Jr, Cauthen GM. Extrapulmonary tuberculosis in the United States. American Review of Respiratory Disease 1990; 141 (2): 347-351. Doi: 10.1164/ajrccm/141.2.347.
Guenifi W, Boukhrissa H, Gasmi A, Rais M, Ouyahia A, Hachani A, Diab N, Mechakra S, Lacheheb A. Thromboses veineuses cérébrales au cours de la méningo-encéphalite tuberculeuse. Journal des Maladies Vasculaires 2016 ; 41 (3): 210-214. Doi: 10.1016/j.jmv.2016.03.002.
Mansare ML, Atsa Kouda DC, Diallo IM, Ntenga P, Boubacar S, Gams MD, Ndiaye MM. Thrombose du sinus caverneux : un cas clinique révélant une tuberculose multifocale et revue de la littérature. African Journal of Neurological Sciences 2017; 36 (2): 33-42.
Hot A, Ninet J. Thromboses veineuses de localisation plus rare. In : Cardiologie et maladies vasculaires. Paris : Elsevier Masson, 2007, pp.1157-1161.
Fleury O, Sibon I. Tuberculose. In: Alamowitch S, Vahedi K, Touzé E (Eds). In : Causes rares des maladies vasculaires cérébrales. Paris : Doin, 2013, pp.29-49.
Alliez JR, Balan C, Diallo O, Alliez B. Mal de Pott et paraplégie pottique. African Journal of Neurological Sciences 2006; 25 (2): 50-59.
Goyal JL, Jain P, Arora R, Dokania P. Ocular manifestations of tuberculosis. Indian Journal of Tuberculosis 2015; 62 (2): 66-73. Doi: 10.1016/j.ijtb.2015.04.004
Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infectious Diseases 2010; 10 (11): 803-812. Doi: 10.1016/S1473-3099(10)70138-9
World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis 2011 update.
https://apps.who.int/iris/beatstream/handle/10665/44597/9789241501583-eng.pdf.
Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY, American Heart Association Stroke Council and the Council on Epidemiology and Prevention. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011 ; 42 (4): 1158-1192. Doi: 10.1161/STR.0b013e31820a8364
Boonsarngsuk V, Mangkang K, Santanirand P. Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. Clinical Respiratory Journal 2018 ; 12 (6): 2101-2109. Doi: 10.1111/crj.12779
Bopaka RG, Okemba Okombi FH, Bemba ELP, Ndinga Essango EB, Ossale-Abacka KB, Koumeka PP, Illoye Ayet M, Atipo-Ibara BI. Prise en Charge de la Tuberculose Multirésistante À Brazzaville. Health Sciences & Disease 2020; 21 (6) : 12-16.
Veziris N, Robert J. Résistance aux antituberculeux et impasse thérapeutique. Médecine/Sciences (Paris) 2010; 26 (11): 976–980. Doi : 10.1051/medsci/20102611976
Fiorot Júnior JA, Felício AC, Fukujima MM, Rodrigues CA, Morelli VM, Lourenço DM, Prado GF. Tuberculosis: an uncommon cause of cerebral venous thrombosis? Arquivos de Neuro-Psiquiatria 2005; 63 (3B): 852-854. Doi: 10.1590/s0004-282x2005000500025
Di Roio C, Jourdan C, Yilmaz H, Artru F. Thrombose des veines cérébrales profondes: trois observations [Cerebral deep vein thrombosis: three cases]. Revue Neurologique 1999; 155 (8): 583-587.
Nagai M, Terao S, Yilmaz G, Yilmaz CE, Esmon CT, Watanabe E, Granger DN. Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis. Stroke 2010; 41 (1): 147-152. Doi: 10.1161/STROKEAHA.109.562983
Chen C, Wang Q, Gao Y, Lu Z, Cui X, Zheng T, Liu Y, Li X, He X, Zhang X, Duan C, Li T. Photothrombosis combined with thrombin injection establishes a rat model of cerebral venous sinus thrombosis. Neuroscience 2015; 306: 39-49. Doi: 10.1016/j.neuroscience.2015.08.020
Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Brain Research 2018; 1699: 54-68. Doi: 10.1016/j.brainres.2018.06.029
Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, Chai H, Ding X, Wang Q. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochemistry International 2020; 141: 104856. Doi: 10.1016/j.neuint.2020.104856
Hu S, Lee H, Zhao H, Ding Y, Duan J. Inflammation and Severe Cerebral Venous Thrombosis. Frontiers in Neurology 2022; 13: 873802. Doi: 10.3389/fneur.2022.873802
Ahui BJM, Horo K, Brou-Gode VC, Kouassi AB, Demine B, Anon JC, Motsebo SF, Bemba EL, AchI VH, N’gom AS, Koffi NB, Kendja K, Aka-Danguy E. Apport du traitement chirurgical de la tuberculose à bacilles résistants au cours du suivi médical (expérience du service de pneumologie du CHU de Cocody : à propos de cinq observations). Revue de Pneumologie Clinique 2011; 67(3): 170-173. Doi : 10.1016/j.pneumo.2010.11.004