Bone Metabolism Profile of Children with Cerebral Palsy in Yaounde (Cameroon)
Profil du Métabolisme Osseux Chez les Enfants avec Paralysie Cérébrale à Yaoundé (Cameroun)
DOI:
https://doi.org/10.5281/hra.v3i1.6283Keywords:
Cerebral Palsy, Bone MetabolismAbstract
RÉSUMÉ
Introduction. Les enfants ayant une paralysie cérébrale sont fréquemment atteints de malnutrition ayant pour conséquence une altération du métabolisme osseux. Ceci les exposerait à des fractures pathologiques, une augmentation de la résorption osseuse, l’ostéoporose, le rachitisme et un retard de croissance. Objectif. Déterminer le profil du métabolisme osseux des enfants atteints de paralysie cérébrale. Matériels et méthodes. Nous avons mené une étude transversale descriptive incluant les enfants atteints de paralysie cérébrale suivis au Centre National de Réhabilitation des Personnes Handicapées de juin à aout 2021. Les données collectées portaient sur les caractéristiques cliniques et les examens biologiques (le métabolisme phosphocalcique (calcémie, phosphorémie), les marqueurs de la formation osseuse (phosphatases alcalines), les marqueurs de la résorption osseuse (calcul de l’indice de Nordin, la parathormone, et la vitamine D). Résultats. Nous avons enrôlé 54 enfants. L’âge moyen était de 36 ± 31,8 mois. La diplégie et la tétraparésie étaient les formes cliniques les plus fréquentes avec une incapacité à s’alimenter chez 57,4% ou à marcher chez 59% des cas. Les anomalies biologiques retrouvées étaient : l’hypocalcémie (45%), l’hypercalcémie (1,8%), l’hypophosphorémie (7,8%), l’hyperphosphorémie (26,9%) ; une hypoparathyroïdie (7,8%) et une hyperparathyroïdie (11,7%) ; une carence en Vitamine D (47,4%) ; une hyperrésorption osseuse avec un indice de Nordin élevé (36,6%). Conclusion. Les enfants avec paralysie cérébrale présentaient de nombreux troubles du métabolisme osseux qu’il faudrait rechercher cliniquement et biologiquement au cours de leur suivi et les prévenir en supplémentant leur alimentation et en les exposant au soleil.
ABSTRACT
Introduction. Children with cerebral palsy frequently suffer from malnutrition, resulting in altered bone metabolism. This exposes them to pathological fractures, increased bone resorption, osteoporosis, rickets and stunted growth. Objective. To describe the bone metabolism profile of children with cerebral palsy. Materials and methods. We conducted a descriptive cross-sectional study including children with cerebral palsy followed at the National Rehabilitation Centre for Disabled Persons from June to August 2021. Data were collected on clinical characteristics and biological examinations (phosphocalcic metabolism (blood calcium, blood phosphorus), markers of bone formation (alkaline phosphatase), markers of bone resorption (calculation of the Nordin index, parathormone, and vitamin D). Results. We enrolled 54 children. The mean age was 36 ± 31.8 months. Diplegia and tetraparesis were the most frequent clinical forms, with an inability to eat in 57.4% of cases and to walk in 59%. The biological abnormalities found were: hypocalcaemia (45%), hypercalcaemia (1.8%), hypophosphaemia (7.8%), hyperphosphaemia (26.9%); hypoparathyroidism (7.8%) and hyperparathyroidism (11.7%); vitamin D deficiency (47.4%); bone hyperresorption with a high Nordin index (36.6). Conclusion. Children with cerebral palsy had numerous bone metabolism disorders that should be investigated clinically and biologically during their follow-up, and prevented by supplementing their diet and exposing them to sunlight.
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Copyright (c) 2024 Kago-Tague Daniel Armand, Sihom Nguidom Yolande, Fojo Talongong Baudelaire, Kamtchum-Tatuene Joseph, Kouam-Mewa Jeannette Euranie, Nguefack Seraphin, Ama Moor Vicky Joceline
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