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Abstract
RÉSUMÉ
Introduction. En chirurgie cardiaque certains patients requièrent une ventilation prolongée en post opératoire bien que l’extubation précoce soit reconnue favorable à de meilleures suites opératoires. L’objectif de cette étude était d’étudier les facteurs associés à une ventilation prolongée de plus de 240 minutes en postopératoire. Patients et Méthodes. Il s’agissait d’une étude prospective au service de CCV B du CHU Ibn Sina de Rabat sur une période de 6 mois. Nous avons exclu les patients âgés de moins de 18 ans, les cas de pneumopathie avérée et les urgences. Les variables étaient décrites en moyennes± écart-types, médianes-quartiles, et effectifs-pourcentages. L’analyse statistique a été réalisée avec les tests de Khi 2, de Man Whitney avec un risque alpha à 5%. Résultats. Nous avons colligé 55 patients avec un âge moyen de 52,08±13,80 ans, un sexe ratio h/f de 1,39. Dix-sept (17) patients étaient de classes ASA III et IV ; 44 (80,0%) étaient classés NYHA III et IV. Quarante patients (72,7%) ont bénéficié d’une chirurgie valvulaire et 13 (23,6%) d’un pontage aortocoronaire. Un ballon de contre pulsion intra aortique (BCPIA) a été utilisé chez cinq (05) patients. Vingt-neuf (52,7%) étaient extubés dans les 240 minutes, et 26 (42,3%) extubés entre 241 et 1020 minutes. Conclusion. Les facteurs prédictifs d’une extubation différée après chirurgie cardiaque à cœur ouvert étaient la pose d’un BCPIA, l’hypothermie (OR =2,053, CI 95% :2,004-13,023, p=0,028) et les anomalies de la gazométrie (OR=2,054, CI 95% : 2,006-7,530, p=0,012).
ABSTRACT
Introduction. The aim of this study was to determine the predictive factors for a delayed extubation after cardiac surgery in which early extubation is associated with favorable postoperative outcomes. However some patients require prolonged mechanical ventilation. Patients and Methods. It has been six months prospective study performed in the cardiovascular surgery department of Ibn Sina Teaching hospital in Morocco. We have excluded patients less than 18 years old, pulmonary diseases and emergencies. Variables have been described as mean ± standard deviations, medians and quartiles. Statistical test were Khi square, Man Whitney with an alpha error of 5%. Results. We have enrolled 55 patients with a mean age of 52,08±13,80 years and a sex ratio M/F of 1,39. Seventeen (17) patients were from ASA 3 and 4 physical status; 44 (80,0%) where NYHA 3 or 4. There were 40 (72,7%) cases of valve replacement and 13 (23,6%) cases of coronary bypass graft. IABP was used in (05) patients. 29 (52,7%) patients have been extubated within 240 minutes, but 26 (42,3%) have been ventilated between 241 and 1020 minutes before extubation. Conclusion. In our study, the identified predictive factors for delayed extubation were the use of IABP, hypothermia (OR =2,053, CI 95%:2,004-13,023, p=0,028) and arterial blood gas disturbances (OR=2,054, CI 95%: 2,006-7,530, p=0,012).
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References
- Hirschi M, Meistelman C, Longrois D. Anesthésie en chirurgie cardiaque en l'an 2000 : place des nouvelles techniques et de l'extubation trachéale précoce. Conférences d'actualisation SFAR. Paris, Elsevier 2000: 215-234.
- Keresztes PA, Kuruzar L. Very early extubation: extubating in the OR following coronary artery bypass. Dimens Crit Care Nurs. 1996; 15(4):198-204.
- Prakash O, Jonson B, Meij S, Bos E, Hugenholtz PG, Nauta J, Hekman W. Criteria for early extubation after intracardiac surgery in adults. Anesth Analg. 1977;56(5):703-708.
- Fraunda S, Behnkeb H, Boeninga A, Cremera J. Immediate postoperative extubation after minimally invasive direct coronary artery surgery. Interactive Cardiovasc and Thorac Surg 1:41-45.
- http://www.ncbi.nlm.nih.gov/pubmed/?term=Habib%20RH%5BAuthor%5D&cauthor=true&cauthor_uid=8823107 Zacharias A, Engoren M. Determinants of prolonged mechanical ventilation after coronary artery bypass grafting. Ann Thorac Surg. 1996; 62(4):1164-71
- Cheng DC, Karski J, Peniston C et al. Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. J Thorac Cardiovasc Surg. 1996; 112(3):755-764,
- Hawkes CA, Dhileepan S, Foxcroft DR. Early extubation for adult cardiac surgical patients. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD003587.
- Dammann JF , Thung N, Christ L , Littlefield JB, Muller WH . The management of the severely ill patient after open-heart surgery. Survey of Anesthesiology. 1963; 7(4): 402-403
- Royse CF, Royse AG, Soeding PF. Routine immediate extubation after cardiac operation. Ann Thorac Surg. 1999 ;68(4):1326-1329
- Canto-Pastor M, Sanchez MJ, Casas MA, Mateu J, Bataller ML. Thoracic epidural analgesia in coronary artery bypass graft surgery: seven years’ experience. Journal of Cardiothoracic and Vascular Anaesthesia 2003;17(2):154–159
- Straka Z, Brucek P, Vanek T, Votava J, Widimsky P. Routine immediate extubation for off-pump coronary artery bypass grafting without thoracic epidural analgesia. Ann Thorac Surg. 2002;74(5):1544-7
- Reyes A, Vega G, Blancas R, Morató B, Moreno JL et al. Early vs Conventional extubation after cardiac surgery with cardiopulmonary bypass. Chest. 1997;112(1):193–201.
- Dumas A, Dupuis GH, Searle N, Cartier R. Early versus late extubation after coronary artery bypass grafting : effects on congnitive function. J Cardiothorac Vasc Anesth. 1999 ; 13(2) :130-135
- Gall SA, Olsen CO, Reves JG, McIntyre RW, Tyson GS, et al. Beneficial effects of endotracheal extubation on ventricular performance. Implications for early extubation after cardiac operations. J Thorac Cardiovasc Surg. 1988;95(5): 819-827.
- Cheng DCH. Fast track cardiac surgery pathways: Early extubation, process of care, and cost containment. Anesthesiology 1998; 88(6):1429-33
- Wong DT, Cheng DCH, Kustra R, Tibshirani R, Karski J, Carroll-Munro J, et al. Risk factors of delayed extubation, prolonged length of stay in the intensive care unit, and mortality in patients undergoing coronary artery bypass graft with fast-track cardiac anesthesia. Anesthesiology 1999; 91(4):936–944.
- Walthall H, Robson D, Ray S. Do any preoperative variables have an effect on the timing of tracheal extubation after coronary artery bypass graft surgery? Heart & Lung. 2001; 30(3): 216-224.
- Marcucci C, Chassot PG. Circulation extracorporelle en chirurgie cardiovasculaire http://www.precisdanesthesiecardiaque.ch/Chapitre7/Machinetcircuischemgen.html Consulté le 10 avril 2018.
- Slinger P. Perioperative lung injury. Best Pract Res Clin Anaesthesiol. 2008;22(1):177-191.
- Sniecinski RM, Levy JH. The Inflammatory Response to Cardiopulmonary Bypass. In: Mongero LB, Beck Jr (eds). On Bypass. Advanced perfusion techniques. Totowa (NJ, USA): Humana Press 2010; 15 p.
- Rashid A, Sattar KA, Dar MI, Khan AB. Analyzing the outcome of early versus prolonged extubation following cardiac surgery. Ann Thorac Cardiovasc Surg. 2008;14(4):218-223.
- London MJ, Shroyer AL, Coll J, MaWhinney S, Fullerton D, Hammermeister KE, Grover FL. Early extubation following cardiac surgery in a veterans population. Anesthesiology 1998; 88(6):1447–1458.
- Kramer AA, Zimmerman JE. Predicting outcomes for cardiac surgery patients after intensive care unit admission. Semin Cardiothorac Vasc Anesth. 2008;12(3):175-183
- Shahbazi Sh, Kazerooni M. Predictive Factors for Delayed Extubation in Intensive Care Unit After Coronary Artery Bypass Grafting Surgeries; A Southern Iranian Experience. Iran J Med Sci. 2012; 37(4):238-241.
- Ettema RG, Peelen LM, Schuurmans MJ, Nierich AP, Kalkman CJ, Moons KG. Prediction models for prolonged intensive care unit stay after cardiac surgery: systematic review and validation study. Circulation. 2010;122(7):682-689.
- Esteve F, Lopez-Delgado JC, Javierre C, Skaltsa K, Carrio ML et al. Evaluation of the PaO2/FiO2 ratio after cardiac surgery as a predictor of outcome during hospital stay. BMC Anesthesiol. 2014;14:83.
- Bando K, Sun K, Binford RS, Sharp TG. Determinants of Longer Duration of Endotracheal Intubation After Adult Cardiac Operations. Ann Thorac Surg 1997;63(4):1026–1033.
- Piotto RF, Ferreira FB, Colósimo FC, Silva GS, Sousa AG, Braile DM. Independent predictors of prolonged mechanical ventilation after coronary artery bypass surgery. Rev Bras Cir Cardiovasc. 2012;27(4):520-528.
- Légaré JF, Hirsch GM, Buth KJ, MacDougall C, Sullivan JA. Preoperative prediction of prolonged mechanical ventilation following coronary artery bypass grafting. Eur J Cardiothorac Surg. 2001; 20(5):930-936.
- Cislaghi F, Condemi AM, Corona A. Predictors of prolonged mechanical ventilation in a cohort of 3,269 CABG patients. Minerva Anestesiol. 2007; 73(12):615-621.
- Suematsu Y, Sato H, Ohtsuka T, Kotsuka Y, Araki S, Takamoto S. Predictive risk factors for delayed extubation in patients undergoing coronary artery bypass grafting. Heart Vessels. 2000;15(5):214-220.
References
Hirschi M, Meistelman C, Longrois D. Anesthésie en chirurgie cardiaque en l'an 2000 : place des nouvelles techniques et de l'extubation trachéale précoce. Conférences d'actualisation SFAR. Paris, Elsevier 2000: 215-234.
Keresztes PA, Kuruzar L. Very early extubation: extubating in the OR following coronary artery bypass. Dimens Crit Care Nurs. 1996; 15(4):198-204.
Prakash O, Jonson B, Meij S, Bos E, Hugenholtz PG, Nauta J, Hekman W. Criteria for early extubation after intracardiac surgery in adults. Anesth Analg. 1977;56(5):703-708.
Fraunda S, Behnkeb H, Boeninga A, Cremera J. Immediate postoperative extubation after minimally invasive direct coronary artery surgery. Interactive Cardiovasc and Thorac Surg 1:41-45.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Habib%20RH%5BAuthor%5D&cauthor=true&cauthor_uid=8823107 Zacharias A, Engoren M. Determinants of prolonged mechanical ventilation after coronary artery bypass grafting. Ann Thorac Surg. 1996; 62(4):1164-71
Cheng DC, Karski J, Peniston C et al. Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. J Thorac Cardiovasc Surg. 1996; 112(3):755-764,
Hawkes CA, Dhileepan S, Foxcroft DR. Early extubation for adult cardiac surgical patients. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD003587.
Dammann JF , Thung N, Christ L , Littlefield JB, Muller WH . The management of the severely ill patient after open-heart surgery. Survey of Anesthesiology. 1963; 7(4): 402-403
Royse CF, Royse AG, Soeding PF. Routine immediate extubation after cardiac operation. Ann Thorac Surg. 1999 ;68(4):1326-1329
Canto-Pastor M, Sanchez MJ, Casas MA, Mateu J, Bataller ML. Thoracic epidural analgesia in coronary artery bypass graft surgery: seven years’ experience. Journal of Cardiothoracic and Vascular Anaesthesia 2003;17(2):154–159
Straka Z, Brucek P, Vanek T, Votava J, Widimsky P. Routine immediate extubation for off-pump coronary artery bypass grafting without thoracic epidural analgesia. Ann Thorac Surg. 2002;74(5):1544-7
Reyes A, Vega G, Blancas R, Morató B, Moreno JL et al. Early vs Conventional extubation after cardiac surgery with cardiopulmonary bypass. Chest. 1997;112(1):193–201.
Dumas A, Dupuis GH, Searle N, Cartier R. Early versus late extubation after coronary artery bypass grafting : effects on congnitive function. J Cardiothorac Vasc Anesth. 1999 ; 13(2) :130-135
Gall SA, Olsen CO, Reves JG, McIntyre RW, Tyson GS, et al. Beneficial effects of endotracheal extubation on ventricular performance. Implications for early extubation after cardiac operations. J Thorac Cardiovasc Surg. 1988;95(5): 819-827.
Cheng DCH. Fast track cardiac surgery pathways: Early extubation, process of care, and cost containment. Anesthesiology 1998; 88(6):1429-33
Wong DT, Cheng DCH, Kustra R, Tibshirani R, Karski J, Carroll-Munro J, et al. Risk factors of delayed extubation, prolonged length of stay in the intensive care unit, and mortality in patients undergoing coronary artery bypass graft with fast-track cardiac anesthesia. Anesthesiology 1999; 91(4):936–944.
Walthall H, Robson D, Ray S. Do any preoperative variables have an effect on the timing of tracheal extubation after coronary artery bypass graft surgery? Heart & Lung. 2001; 30(3): 216-224.
Marcucci C, Chassot PG. Circulation extracorporelle en chirurgie cardiovasculaire http://www.precisdanesthesiecardiaque.ch/Chapitre7/Machinetcircuischemgen.html Consulté le 10 avril 2018.
Slinger P. Perioperative lung injury. Best Pract Res Clin Anaesthesiol. 2008;22(1):177-191.
Sniecinski RM, Levy JH. The Inflammatory Response to Cardiopulmonary Bypass. In: Mongero LB, Beck Jr (eds). On Bypass. Advanced perfusion techniques. Totowa (NJ, USA): Humana Press 2010; 15 p.
Rashid A, Sattar KA, Dar MI, Khan AB. Analyzing the outcome of early versus prolonged extubation following cardiac surgery. Ann Thorac Cardiovasc Surg. 2008;14(4):218-223.
London MJ, Shroyer AL, Coll J, MaWhinney S, Fullerton D, Hammermeister KE, Grover FL. Early extubation following cardiac surgery in a veterans population. Anesthesiology 1998; 88(6):1447–1458.
Kramer AA, Zimmerman JE. Predicting outcomes for cardiac surgery patients after intensive care unit admission. Semin Cardiothorac Vasc Anesth. 2008;12(3):175-183
Shahbazi Sh, Kazerooni M. Predictive Factors for Delayed Extubation in Intensive Care Unit After Coronary Artery Bypass Grafting Surgeries; A Southern Iranian Experience. Iran J Med Sci. 2012; 37(4):238-241.
Ettema RG, Peelen LM, Schuurmans MJ, Nierich AP, Kalkman CJ, Moons KG. Prediction models for prolonged intensive care unit stay after cardiac surgery: systematic review and validation study. Circulation. 2010;122(7):682-689.
Esteve F, Lopez-Delgado JC, Javierre C, Skaltsa K, Carrio ML et al. Evaluation of the PaO2/FiO2 ratio after cardiac surgery as a predictor of outcome during hospital stay. BMC Anesthesiol. 2014;14:83.
Bando K, Sun K, Binford RS, Sharp TG. Determinants of Longer Duration of Endotracheal Intubation After Adult Cardiac Operations. Ann Thorac Surg 1997;63(4):1026–1033.
Piotto RF, Ferreira FB, Colósimo FC, Silva GS, Sousa AG, Braile DM. Independent predictors of prolonged mechanical ventilation after coronary artery bypass surgery. Rev Bras Cir Cardiovasc. 2012;27(4):520-528.
Légaré JF, Hirsch GM, Buth KJ, MacDougall C, Sullivan JA. Preoperative prediction of prolonged mechanical ventilation following coronary artery bypass grafting. Eur J Cardiothorac Surg. 2001; 20(5):930-936.
Cislaghi F, Condemi AM, Corona A. Predictors of prolonged mechanical ventilation in a cohort of 3,269 CABG patients. Minerva Anestesiol. 2007; 73(12):615-621.
Suematsu Y, Sato H, Ohtsuka T, Kotsuka Y, Araki S, Takamoto S. Predictive risk factors for delayed extubation in patients undergoing coronary artery bypass grafting. Heart Vessels. 2000;15(5):214-220.