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Abstract

Introduction: HIV infection is responsible for many biochemical disorders among which lipid peroxidation and antioxidant imbalance are of important consideration. HIV infection is a chronic disease which leads to chronic inflammation during which high amount of free radicals are produced. These free radicals lead to very high lipid peroxidation indices and to rapid disease progression due to CD4 cells apoptosis.

Objectives: We determined lipid peroxidation indices (LPI), plasma malondialdehyde (MDA) concentration and total antioxidant ability of plasma (TAA) concentration in hiv-positive, treatment-naïve patients in order to contribute to the management of HIV-infected patients.

 

Methodology: We measured MDA and TAA concentrations, and LPI indices in 285 individuals composed of 151 HIV-positive treatment-naïve patients and 134 controls that were recruited during a period of twelve months at the University Hospital Center in Yaoundé and in the South West region.

 

Results: Values of the various parameters obtained were We obtained the following patients/controls values for MDA (0, 41±0, 10 µM patients vs 0, 20±0, 07µM for controls), TAA (0, 16±0, 16 mM for patients vs 0, 63±0, 17 mM for controls) and LPI indices (26, 02±74, 40 for patients vs 0, 34±0, 14 for controls). The differences between patients and controls were statistically significant (p<0, 05) for all the parameters. There was a statistically significant decrease in TAA concentration in term of CD4 cell counts (p<0, 05) and a positive correlation between the both (r=0,199; p<0, 05). In term of sex, LPI and MDA were higher while TAA was lower in men compared to women (p<0, 05).

 

Conclusion: During HIV infection there is high lipid peroxidation, low plasma total antioxidant ability and very high LPI indices. This may be linked to chronic inflammation due to HIV infection which produces free radicals during HIV replication. These disorders contribute to CD4 cells apoptosis and disease progression.

Keywords

MDA TAA LPI Free radicals HAART HIV infection

Article Details

How to Cite
Teto, G., Kanmogne, D. G., & Ntorimiro, J. (2013). VERY HIGH LIPID PEROXIDATION INDICES IN HIGHLY ACTIVE ANTIRETROVIRAL (HAART)-NAÏVE HIV-POSITIVE PATIENTS IN CAMEROON. HEALTH SCIENCES AND DISEASE, 12(4). https://doi.org/10.5281/hsd.v12i4.119
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