Article Sidebar

Download
PDF

Main Article Content

Abstract

ABSTRACT

Purpose: Hospital personnel are often colonized with resistant strains of Staphylococcus aureus (SA). These strains could be transmitted to patients, complicating treatment options particularly in resource-limited areas where antimicrobial susceptibility assessment is not systematic.  In view of guiding empiric treatment in such patients, we assessed antimicrobial susceptibility profile of SA isolated from the anterior nares of hospital personnel of three health institutions in Yaounde, Cameroon in a cross sectional study. We also assessed risk factors associated with the presence of Methicillin Resistant Staphylococcus aureus (MRSA). 

Methods: The antibiotic susceptibility profile of fifty eight SA strains isolated from hospital personnel to sixteen commonly used antibiotics was assessed using the Kirby Bauer disk diffusion method. Methicillin resistant strains were determined by the Oxacillin Minimum Inhibitory concentration technique.

Results:   All the isolates were resistant to penicillin, ampicillin, and amikacin. No resistance was recorded for netilmicin, vancomycin, and low for gentamicin, rifampin and cephalotin. Eight (13.8%) of the isolates were found to be MRSA. We found 85% of MRSA to be resistant to more than six of the tested antibiotics.  No association was found between demographic variables or personal habits and nasal colonization with methicillin-resistant strains.

Conclusion: A relatively high proportion of SA isolates in this study were resistant to commonly used antibiotics. This calls for regular monitoring of susceptibility patterns. 

Key words: Staphylococcus aureus, Hospital personnel, resistance, MRSA

 

 

 

 

 

 

Article Details

How to Cite
Eyoh, A. B., Eyoh, A. B., Toukam, M., Gonsu, H., Fokunang, C., Lyonga, E. E., Ikomey, G. M., Mukwele, B. N., Mesembe, M., Tsague, N., Mandi, H., & Okomo Assoumou, M. C. (2013). ANTIBIOTICS SUSCEPTIBILITY PROFILE OF STAPHYLOCOCCUS AUREUS ISOLATED FROM THE ANTERIOR NARES OF HOSPITAL PERSONNEL IN YAOUNDE, CAMEROON. HEALTH SCIENCES AND DISEASE, 14(2). https://doi.org/10.5281/hsd.v14i2.146
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. References
  2. Kluytmans, JA, Van Belkum and Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology Underlying mechanisms, and associated risks. Clin. Microbiol. 1997 Rev. 10: 505-520.
  3. Lowy FD. Staphylococcus aureus infections. N. Engl. J. Med 1998. 339: 520-532.
  4. Chambers HF. The changing epidemiology of staphylococcus aureus? Emerg Infect Dis 2001. 7: 178-182.
  5. Von Eiff C, Becker K, Machka K, Stammer H and Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia N. Engl. J. Med 2001. 344: 11-16
  6. Yazgi H, Ertek M, Ozbek A and Kadanali A. Nasal carriage of Staphylococcus aureus in hospital personnel and the normal population and antibiotic resistance isolates. Mikrobiyol Bul. 2003; 37(2-3): 137.
  7. Goyal R., Das S., and Mathur M. Colonization of methicillin resistant Staphylococcus aureus among health care workers in a tertiary care hospital of Delhi. India J Med Sci 2002; 56: 321-324.
  8. Lowy FD. Antibiotic resistance the example of Staphylococcus aureus. J. Clin. Invest, 2003; 111: 1265-1273.
  9. Johnson AP, Pearson A and Duckwroth G. “Surveillance and epidemiology of MRSA bacteremia in the UK”. J Antimicrob Chemother. 2005; 56(3) 455-462.
  10. Werner CA., Stephan H. Health Workers: Source, Vecto rs or Victims of MRSA? Lancet infect Dis 2008; 289-3011
  11. Aires De S, Santos S, Ferro ML and Lencastre H D. Epidemiology study of Staphylococcus aureus colonization and cross infection in two West African hospitals. Microb. Drug Resist. 2000; 6: 133-141.
  12. Eyoh AB, Toukam M, Okomo A. M.C, Fokunang C, Atashili J, Lyonga E, Ikomey G, Mukwele B, Mesembe M, Akongnwi E, Ndumbe P. Nasal carriage of Staphylococcus aureus by hospital personnel of three health institutions in Yaounde Cameroon. IRJM. 2012; 2 (7) ,
  13. Monica Cheesbroug. District laboratory Practice in Tropical Countries. Part 2. Cambridge University press. 2003; 157-158.
  14. NCCL. Performance Standards for Antimicrobial Disc Susceptibility Test Approved StandardM2-A5. Villanova Pan, USA: National Committee for Clinical Laboratory Standards, 1993.
  15. Fusi Ngwa CN, Payne VK, Asakizi AN. Antibiotic resistance in Candida albicans and Stahpylococcus aureus involved in vaginitis: Case study of Dschang town, Cameroon. Cameroon Journal of Experimental Biology. 2007;l 3 (1) 20-25.
  16. Adebola O. and Onaolapo J. Antimicrobial susceptibility of S. aureus isolated from healthy women in Zaria Nigeria. Nigeria Tropical Journal of Pharmaceutical Research, 2008; 7 (1): 929-934.
  17. Richman PB, Garra G, Eskin B, Nashed AH, Cody R. Oral antibiotic use without consulting a physician: a survey of ED patients. Am J Emerg Med. 2001: 1(1): 57-60.
  18. Classen DC, Pestotnik Sl, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients, Excess length of stay, extra cost, and attributable mortality. JAMA. 1997 277(4) 301-306.
  19. Onanuga A, Oyi AR, Olanyinka BO, and Onaolapo JA, Prevalence of Community associated multiresistant Staph. aureus in healthy women in Abuja Nigeria. African Journal of Biotechnology, 2005, 4 (9): 942-945.
  20. Kesah C, Ben R. S, Odugbemi TO, Boye CS, Dosso M, Ndinya JO et al. Prevalence of methicillin-resistant Staphylococcus aurues in eight African hospitals and Malta. Clin Microbiol infect. 2003 9 (2): 153-156.
  21. Harbarth S, Liassine N, Dharan S, herrault P, Auckenthaler R, Pittet D, Risk factors for persistent carriage of methicillin-resistant staphylococcus aureus. Clin infect Dis 2000; 31: 1380-85.
  22. Christian C, Maureen M, Bianca Q, Peter V, Robert SK and Franklin DL. Differences between Staphylococcus aurues isolated from medical and non medical hospital personnel. Journal of Clinical Microbiology 2002; 40(7) 2594-2597.

Most read articles by the same author(s)

<< < 1 2 3 > >>