Effets Inhibiteurs de l’Huile Essentielle et des Extraits Bruts des Écorces de Greenwayodendron Suaveolens (Engl. & Diels) Verdc. Subsp. Suaveolens contre les Bactéries Responsables de la Pneumonie

PH Betote Diboue, Nga Nnanga, FC Benga Mekoulou, P Obono Fouda Mballa, SS Beack Bayengue, DA Tchamgoue, MA Nyegue


Objectif. Dans la présente étude, l’huile essentielle et les extraits bruts des écorces de Greenwayodendron suaveolens (Engl. & Diels) Verdc. subsp. suaveolens ont été testés in vitro pour leur potentiel antibactérien contre les bactéries responsable de la pneumonie. Méthodologie. Le potentiel in vitro antibactérien de l’huile essentielle et des extraits bruts a été testé en utilisant les méthodes de diffusion sur disque et de microdilution en milieu liquide. Résultats. Les résultats obtenus ont montré que les extraits testés ont une activité antibactérienne contre les agents pathogènes sélectionnés avec des diamètres de zones d’inhibition variant respectivement de 7,27 mm pour Klebsiella pneumoniae à 13,38 mm pour Haemophilus influenzae. Concernant les paramètres d’inhibition, l’huile essentielle et les extraits bruts ont également montré une activité antibactérienne avec des concentrations minimales inhibitrices comprises entre 58,59 µg/mL et 1875 µg/mL ; la plus forte activité attribuée à l’huile essentielle pour l’inhibition de la croissance de Escherichia coli. Conclusion. Les résultats de la présente investigation indiquent que les extraits des écorces de Greenwayodendron suaveolens ont le potentiel d’inhiber efficacement la croissance de Klebsiella pneumoniae ATCC 43816, Haemophilus influenzae ATCC 49247, Pseudomonas aeruginosa ATCC 27853 et Escherichia coli ATCC 35218, responsables de la pneumonie. Cependant, l’isolement des composés bioactifs est nécessaire pour les futures investigations.

Objective. In this study, the essential oil and crude extracts from the stem-barks of Greenwayodendron suaveolens (Engl. & Diels) Verdc. subsp. suaveolens was tested for their in vitro antibacterial efficacy against pneumonia bacteria. Methodology. The essential oil and crude extracts were tested for their in vitro antibacterial potential using the disc diffusion and microdilution methods. Results. Our results showed that the tested extracts had antibacterial activity against the selected pneumonia pathogens with the zones of inhibition ranging from 7.27 mm for Klebsiella pneumoniae to 13.38 mm for Haemophilus influenzae respectively. The essential oil and crude extracts also shown antibacterial activity highlighting the minimum inhibitory concentrations (MICs) ranging from 58.59 µg/mL to 1875 µg/mL with the highest activity attributed to essential oil for inhibiting the growth of Escherichia coli. Conclusion. The present findings indicated that the extracts of stem-barks of Greenwayodendron suaveolens has the potential to inhibit effectively the growing of Klebsiella pneumoniae ATCC 43816, Haemophilus influenzae ATCC 49247, Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 35218, responsible of pneumonia. However, the isolation of bioactive components is a toolkit for further investigations. 


Huile essentielle, extraits bruts, Greenwayodendron suaveolens, potentiel antibactérien, pneumonie

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