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Sister Mary Joseph's nodule is a metastatic umbilical nodule usually associated with the primary neoplasm of the gastrointestinal and genitourinary tract. Umbilical metastasis is rare in clinical practice. It can be the first sign of an undiagnosed neoplasm or can appear as a recurrence or progression of an already known tumor, and usually indicate poor prognosis. We report three cases of Sister Mary Joseph's nodule which emphasize the importance of correctly diagnosing an umbilical nodule.

Le nodule de Sœur Marie-Joseph est une métastase cutanée ombilicale d'un cancer du tractus gastrointestinal ou de la sphère gynécologique. C'est une lésion rare qui peut être inaugurale ou apparaître dans le cadre d'un cancer connu et signe une récidive ou une progression néoplasique. Sa présence est souvent associée à un mauvais pronostic. Nous rapportons 03 cas de nodule de soeur Mary Joseph qui soulignent l'importance de diagnostiquer correctement un nodule ombilical.


Sister Mary Joseph's nodule, skin metastasis, umbilicus, cancer

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Adani-Ifè, A. ., Alassani, F. ., Doh, K. ., Tchangaï, B. ., & Djibril, M. . (2022). Sister Mary Joseph Nodule: Three Case Reports of Unusual Skin Metastasis. HEALTH SCIENCES AND DISEASE, 23(5). Retrieved from


  1. Schoijet IM, Rojas AA, Cortes C, Varela CU. Sister Mary Joseph's nodule: from history to the images. a case-based literature review. Acta Gastroenterol Latinoam. 2018;48(2):82-89.
  2. Touraud JP, Lentz N, Dutronc Y, Mercier E, Sagot P, Lambert D. Umbilical cutaneous metastasis (or Sister Mary Joseph's nodule) disclosing an ovarian adenocarcinoma. Gynecol Obstet Fertil. 2000; 28; 719-21.
  3. Dubreuil A, Dompmartin A, Barjot P, Louvet S, Leroy D. Umbilical metastasis or Sister Mary Joseph's nodule. Int J Dermatol. 1998;37(1):7–13
  4. Gabriele R, Conte M, Egidi F, Borghese M. Umbilical metastases: current viewpoint. World J Surg Oncol 2005; 3:13.
  5. Gibson J.A. G, Thompson W. R, Konamme S, Bhattacharya S. Sister Mary Joseph nodule: a diagnostic challenge, BMJ Case Rep. (2018), bcr-2017-223674 Sister.
  6. Galvan VG. Sister Mary Joseph's nodule. Ann Intern Med, 1998,128 (5):410.
  7. Bailey H. Demonstration of Physical Signs in Clinical Surgery. 11th ed, Baltimore: Williams & Wilkins, 1949
  8. Vekariya P, Daneti D.B, Selvan K.S, Verma S.K, Hamide A, Mohan P. Sister Mary Joseph Nodule as an Initial Presentation of Pancreatic Adenocarcinoma. ACG Case Rep J 2020;7: e00453. doi:10.14309/crj.0000000000000453.
  9. Dar I.H, Kamilia M.A, Dara S.H, Kuchaai F.A. a Sister Mary Joseph nodule-A case report with review of literature JRMS. 2009; Vol 14, No 6.
  10. Trebing D, Göring HD. [The umbilical metastasis. Sister Mary Joseph and her time]. Hautarzt. 2004;55(2):186-9. German. PMid:14968331
  11. Gabriele R, Borghese M, Conte M, Basso L. Sister Mary Joseph's nodule as a first surgery of cancer of the cecum: report of a case. Dis colon rectum. 2004; 47:115-7.
  12. Tso S, Brockley J, Recica H, et al. Sister Mary Joseph's nodule: an unusual but important physical finding characteristic of widespread internal malignancy. Br J Gen Pract. 2013; 63:551–2.
  13. Iavazzo C, Madhuri K, Essapen S, Akrivos N, Tailor A, ButlerManuel S. Sister Mary Joseph's nodule as a first manifestation of primary peritoneal cancer. Case Rep Obstet Gynecol. 2012;2012: 467240.