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Abstract

RÉSUMÉ
Introduction. Il s'agissait d'analyser les effets du tériparatide sur l'ostéonécrose de la mâchoire liée à l'alendronate chez les rats. Matériaux et méthodes. Il s’agissait d’une étude préclinique de rats mâles wistar, menée sur une durée de 6 mois à l’animalerie de la Faculté de Médecine et des Sciences biomédicale de Yaoundé. Les rats sélectionnés ont reçu per os de l’alendronate à 0,1 mg/kg /semaine pendant 8 semaines. A la 8ième semaine, les rats atteints d’une ostéonécrose des mâchoires de stade 2 et 3 ont été inclus et répartis en groupes 1 et 2 (tériparatide en sous cutanée à 10 et 20 µg/kg 2 fois par semaine pendant 8 semaines) et groupe 3 (sérum physiologique en sous cutanée). À la 16ième semaine, en plus d'un contrôle clinique, les rats ont été sacrifiés et les mâchoires ont été insérées dans la résine polyacrylique pour une tomodensitométrie. Résultats. 44 rats ont été inclus et répartis aléatoirement en 3 groupes soit 30 dans le groupe 1 et 2 et 14 dans le groupe 3. Au cours de la 16ième semaine expérimentale 12 rats du groupe 1 avec un stade 2 et 3 d’ONM ont présenté une amélioration clinique de la maladie du stade 2 au stade 1. Dans le groupe témoin, seulement 3 rats ont montré une progression du stade 3 vers le stade 2. Conclusion. Le tériparatide administré en intermittence pourrait être un traitement efficace dans la résolution de l’ostéonécrose des mâchoires.
ABSTRACT
Introduction. The aim of the study was to investigate the effects of teriparatide on alendronate-related osteonecrosis of the jaw in rats. Materials and methods. This was a preclinical study of male wistar rats, conducted over a period of 6 months at the animal house of the Faculty of Medicine and Biomedical Sciences, Yaounde. The selected rats received alendronate 0.1 mg/kg/week for 8 weeks. At week 8, rats with stage 2 and 3 osteonecrosis of the jaws were included and divided into groups 1 and 2 (subcutaneous teriparatide at 10 and 20 µg/kg twice a week for 8 weeks) and group 3 (subcutaneous saline). At week 16, in addition to a clinical check-up, the rats were sacrificed and the jaws were inserted into the polyacrylic resin for a CT scan. Results. 44 rats were included and randomly divided into 3 groups: 30 in group 1 and 2 and 14 in group 3. During the 16th experimental week 12 rats in group 1 with stage 2 and 3 ONM showed clinical improvement of the disease from stage 2 to stage 1. In the control group only 3 rats showed progression from stage 3 to stage 2. Conclusion. Teriparatide administered intermittently may be an effective treatment for the resolution of osteonecrosis of the jaws.

Keywords

teriparatide wistar rats alendronate osteonecrosis of the jaw tériparatide rats wistar alendronate ostéonécrose de la mâchoire

Article Details

How to Cite
Ntep Ntep David Bienvenue, Bola Siafa , . A., Mballa Amougou , J. C., Nko’o Amvene , S., & Bengondo Messanga , C. (2022). Effet du Tériparatide sur la Résolution de l’Ostéonécrose des Mâchoires Induite par l’Administration de l’Alendronate chez le Rat Wistar. HEALTH SCIENCES AND DISEASE, 23(11). https://doi.org/10.5281/hsd.v23i11.3976

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