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Abstract

ABSTRACT
Introduction. COVID-19 appears to have a vascular tropism responsible for diffuse vasculitis-like cell damage. The aim of our study was to evaluate the impact of Sars-Cov-2 infection on arterial stiffness. Material and methods. This was a cross-sectional analytical case-control study with 1:1 matching (1 case to 1 control) over a six-month period from January 1, 2021 to June 30, 2021 at the medical-social center of the autonomous port of Douala. We measured the pulse wave velocity (PWV) in two groups of patients (group 1: COVID-19 and group 2: non-COVID-19) using a MOBIL-O-GRAPH 24h PWA MonitorTM. A p-value < 0.05 was considered significant. Result. A total of 122 patients (61 COVID-19 and 61 non-covid) were included in this study, among which 68 (55.7%) male. The mean age was 41±11 years. PWV as well as POV adjusted for age and mean BP were similar in both groups. The mean 24-hour, diurnal and nocturnal PWV were slightly higher in COVID-19 patients than in controls by 0.1 m/s (p=0.67), 0.2m/s (p=0.37) and 0.2m/s (p=0.25) respectively. COVID-19 infection was not significantly associated with PWV (p=0.082). Conclusion. PWV were slightly higher in COVID-19 patients and increased arterial stiffness was not significantly associated with COVID-19 status in the acute phase of infection.


RESUME
Introduction. La Covid- 19 semble avoir un tropisme vasculaire responsable des lésions cellulaires semblables à une vascularite diffuse. Le but de notre étude était d'évaluer l'impact de l'infection au Sars-Cov-2 sur la rigidité artérielle. Matériels et méthodes. Il s’agissait d’une étude transversale analytique de type cas témoins avec appariement 1/1 (1 cas pour 1 témoin) sur une période six mois allant du 01er Janvier 2021 au 30 Juin 2021, au centre médico-social du port autonome de Douala. Nous avons mesuré la vitesse de propagation de l'onde de pouls (VOP) dans deux groupes de patients (groupe 1 : COVID-19 et groupe 2 : non COVID-19) à l’aide d’un appareil de marque MOBIL-O-GRAPH 24h PWA MonitorTM. Une valeur p < 0,05 était considérée significative. Résultats. Sur un total de 122 patients (61 COVID-19 et 61 non covid) inclus, 68 (55,7%) de sexe masculin. L’âge moyen était de 41±11 ans. La VOP ainsi que la VOP ajustée à l'âge et à la PA moyenne étaient similaires dans les deux groupes. Les VOP moyennes sur 24h, diurne et nocturne étaient légèrement élevées chez les patients COVID-19 que chez les témoins de 0,1 m/s (p=0.67), 0.2m/s (p=0.37) et 0.2m/s (p=0.25) respectivement. L'infection à COVID-19 n’était pas significativement associée à la VOP (p=0.082). Conclusion. Les VOP étaient légèrement plus élevées chez les patients COVID-19 et l’augmentation de la rigidité artérielle n’est pas significativement associée au statut COVID-19 à la phase aiguë de l’infection.

Keywords

Covid-19 infection, arterial stiffness, pulse wave velocity, Douala infection à Covid-19, Rigidité artérielle, vitesse de l’onde de Pouls, Douala

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Author Biographies

Siddikatou Djibrilla, Laquintinie Hospital in Douala

Faculty of Medicine and Pharmaceutical Sciences of Douala.

Félicité Kamdem, Douala General Hospital.

Faculty of Medicine and Pharmaceutical Sciences of Douala.

Léon Jules Owona Manga

Faculty of Medicine and Pharmaceutical Sciences of Douala.

Anastase Dzudie Tamdja, Douala General Hospital.

Faculty of Medicine and Biomedical Sciences of Yaounde.
How to Cite
Mouliom, S. A. ., Ndom, M. S., Djibrilla, S., Ngando , G., Viché, L. ., Kamdem, F., Owona Manga, L. J., & Dzudie Tamdja, A. (2022). Association of Acute COVID-19 with 24 Hours-Pulse Wave Velocity in Cameroonian Workers . HEALTH SCIENCES AND DISEASE, 24(1). https://doi.org/10.5281/hsd.v24i1.4134
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