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Introduction. The occurrence of hepatocellular carcinoma (HCC) is closely linked to that of viral hepatitis. In Cameroon, a country with a high endemicity of viral hepatitis, HCC is the most frequent digestive cancer. Our aim was to evaluate the survival and prognostic factors of hepatocellular carcinoma in three referral hospitals in Cameroon. Methodology. This was a cross-sectional, analytic study conducted over a period from January 1, 2009 to December 31, 2016 in three referral hospitals in the cities of Douala and Yaoundé, Cameroon. All patients with hepatocellular carcinoma diagnosed histologically or by typical CT images and alpha-fetoprotein elevation above 200 ng/ml were included. Sociodemographic, clinical, paraclinical, therapeutic and evolutionary data were collected. Survival curves were obtained using the Kaplan-Meier method. Univariate and multivariate logistic regression was used to identify factors independently associated with prognosis at a significance level of p<0.05. Results. We collected 925 patient records, 357 of whom were carriers of hepatocellular carcinoma, representing a hospital frequency of 38.6%. The mean age was 51.8 ±17.5 years, with males accounting for 73.6% of cases. The main etiologies were viral hepatitis B and C in 49.9% and 47.1% respectively. Cirrhosis was present in 89.9% of cases. The main clinical signs were abdominal pain (78.2%), ascites (70.3%) and jaundice (69.2%). Alpha-fetoprotein levels were above 200 ng/ml in 54.6% of cases. Radiologically, there were more than 03 hepatic nodules in 77% of cases, larger than 3cm in 85.7%. Portal invasion was present in 35.6% of cases, and metastases in 41.5%. According to the Barcelona BCLC classification, the tumor was classified C and D in 39.5% and 28% of cases respectively. Treatment was palliative in 96.1% of cases, mainly sorafenib (58.9%). Overall survival was 8.8 months, with a 6-month survival of 23.2%. Factors associated with death were impaired general condition (OR=10.67; CI95%: 4.55 - 15.62; p<0.0001) portal invasion (OR=7.83; CI95%: 3.73 - 12.69; p=0.002), BCLC stage (OR= 3.42; IC95%: 1.48 - 5.89; 0.008) and palliative treatment (OR= 2.85; IC95%: 1.54 - 6.27; p=0.006). Conclusion. Hepatocellular carcinoma has a hospital incidence of 38.6% and an overall survival of 8.8 months. Prognostic factors include tumour stage, portal invasion and type of treatment.

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Bekolo Nga Winnie Tatiana, Eloumou Bagnaka Servais Albert Fiacre, Maïson Anne, Ndjitoyap Ndam Antonin, Agnès Malongue, Noah Noah Dominique, … Luma Henry Namme. (2024). Facteurs Pronostiques du Carcinome Hépatocellulaire au Cameroun : Une Étude Transversale . HEALTH SCIENCES AND DISEASE, 25(2 Suppl 1). https://doi.org/10.5281/hsd.v25i2 Suppl 1.5290
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