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Abstract

RÉSUMÉ
La trisomie 21 ou syndrome de Down (SD) est une aberration chromosomique, caractérisée par une déficience intellectuelle. Elle est souvent associée à des troubles de la fonction thyroïdienne, avec une prédominance de l’hypothyroïdie. Son association à l’hyperthyroïdie est rare. Nous rapportons le cas d’un enfant de 9 ans, atteint de SD reçu dans un contexte d’amaigrissement, goitre, tachycardie et exophtalmie chez qui le bilan hormonal retrouvant une TSH˂ 0,005 µUI/ml (0,27-4,2 µUI/ml) et une FT4 : 81,3 pmol/l (12- 22 pmol/l), les TRAb> 68 IU/l a permis de poser le diagnostic d’une hyperthyroïdie (maladie de Basedow). La prise en charge a été faite selon les recommandations et l’évolution était favorable.


ABSTRACT
Trisomy 21 or Down syndrome (DS) is a chromosomal aberration, characterized by intellectual disability. It is often associated with disorders of thyroid function, with a predominance of hypothyroidism. Its association with hyperthyroidism is rare. We report the case of a 9-year-old child with DS seen in a context of weight loss, goiter, tachycardia and exophthalmos in whom the hormonal assessment found TSH˂ 0.005 µIU/ml (0.27-4.2 µIU/ml) and FT4: 81.3pmol/l (12-22 pmol/l), TRAb > 68 IU/l suggestive of the diagnosis of hyperthyroidism (Graves’ disease). The management was carried out according to the recommendations and the evolution was favorable.

Keywords

Trisomy 21, Hyperthyroidism, Graves’ disease, Pointe-Noire Trisomie 21, Hyperthyroïdie, Basedow, Pointe-Noire

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How to Cite
C L Elenga-Bongo, A Bandoho Mombo, R L Mayanda, M G Monabeka, C C Yidika Moussavou, F Elilié Ongoth, E Bouenizabila, L A Bugova, & H G Monabeka. (2024). Graves’ Disease and Trisomy 21: A Case Report from Pointe-Noire: Maladie de Basedow et Trisomie 21 : A Propos d’Un Cas à Pointe-Noire. HEALTH SCIENCES AND DISEASE, 25(12). https://doi.org/10.5281/hsd.v25i12.6231
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