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Abstract
RÉSUMÉ
Le léiomyosarcome est composé de cellules à différenciation musculaire lisse et est le deuxième type histologique de sarcome rétropéritonéal le plus fréquent après le liposarcome. Connu pour son pronostic sombre, la néphrectomie élargie reste le gold standard pour les formes localisées. Nous rapportons un cas de léiomyosarcome rénal traité au service d’urologie de l’hôpital principal de Dakar. Il s’agissait d’une patiente de 55 ans qui a subi une exérèse d’une volumineuse masse lombaire gauche. L’aspect histologique et immunohistochimique était celui d’un léiomyosarcome du rein de grade II selon FNCLCC. Le bilan d’extension était négatif. Quatre ans après l’opération, la patiente était vivante et bien portante sans signe de récidive locale ou de métastase.
ABSTRACT
Leiomyosarcoma (LMS) comprises smooth muscle differentiating cells and is the second most common type of retroperitoneal sarcoma after liposarcoma. The prognosis of LMS is generally poor and extended nephrectomy is the gold standard surgical modality for localized tumor. We report one case of renal LMS that was treated at the urology department of the Hospital Principal in Dakar. The 55-year-old female patient had extended monobloc removal of the tumor. histological and immunohistochemical analysis showed a grade II renal leiomyosarcoma (FNCLCC). Extension workup was negative; Four years later, the patient was alive with no sign of local recurrence or distance metastasis.
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References
- Pham V, Henderson-Jackson E, Doepker MP, Caracciolo JT, Gonzalez RJ, Druta M, et al. Practical issues for retroperitoneal sarcoma. Cancer Control 2016;23(3):249—64.
- Messiou C, Morosi C. Imaging in retroperitoneal soft tissue sarcoma. J Surg Oncol 2018;117(1):25—32
- Kwon YS, Salmasi A, Han CS, Hon JD, Singer EA. Renal leiomyosarcoma: case report and review of the literature. World J Nephrol Urol. 2015;4:213– 7.
- Demir A, Yazici CM, Eren F, Türkeri L. Case report: good prognosis in leiomyosarcoma of the kidney. Int Urol Nephrol. 2007 ;39:7– 10.
- Kendal WS. The comparative survival of renal leiomyosarcoma. Can J Urol. 2007 14:3435–42.
- Gupta S, Jimenez RE, Folpe AL, Cheville JC. Renal Leiomyoma and leiomyosarcoma: a study of 57 cases. Am J Surg Pathol. 2016 ;40:1557– 63
- Beardo P, José Ledo M, Jose Luis RC. Renal leiomyosarcoma. Rare Tumors. (2013) 5:e42.
- Deyrup AT, Montgomery E, Fisher C. Leiomyosarcoma of the kidney: a clinicopathologic study. Am J Surg Pathol 2004 : 28: 178-82.
- Ouardani ME, Iken A, Sayegh HE. Leiomyosarcome renal (à propos de deux cas). J Maroc Urol 2007; 8: 29-31.
- Vasquez Ciriaco S, García Espinoza JA, Garcia Pedro EE. Primary leiomyosarcoma of kidney with metastasis to contralateral kidney. Case report. Interv Med Appl Sci. 2018;10(2):98-101.
- Diallo Y, Kouka SC, Ondo CZ, Sow Y, Fall B, Diao B, et al. Un cas de léiomyosarcome rénal géant. Rev. méd. Madag. 2014 ; 4(1) : 382-84
- Chen C, Jiang X, Xia F, Chen X and Wang W (2021) Clinicopathological Characteristics and Survival Outcomes of Primary Renal Leiomyosarcoma. Front. Surg. 8:704221.
- Moazzam M, Ather MH, Hussainy AS. Leiomyosarcoma presenting as a spontaneously ruptured renal tumor-case report. BMC Urol. 2002 ;2:13.
- Dominicia A, Mondainia N, Nesib G, Travaglinia F, Di Celloa V et Rizzoa. Cystic Leiomyosarcoma of the Kidney: An Unusual Clinical Presentation. Urol Int 2000;65:229–31.
- Darlington D, Anitha F. Atypical Presentation of Renal Leiomyosarcoma: A Case Report. Cureus 11(8): e5433
- Makni, A., Rebai, W., Chebbi, F. Daghfous A, Ayadi S et Ben Safta Z. Cas clinique leiomyosarcome du rein: A propos d’un cas. Afr J Urol ,(2010)16 ;4 134-136
- Kurugoglu S, Ogut G, Mihmanli I, Korman U, Durak H. Abdominal leiomyosarcomas: radiologic appearances at various locations. Eur Radiol 2002;12:2933-42.
- Merran S, Karila Cohen P, Vieillefond A. Tumeurs retroperitoneales primitives de l’adulte. [Primary retroperitoneal tumors in adults]. J.Radiol. 2004; Feb;85(2 Pt 2):252-64
- Dhawan S, Chopra P, Dhawan S. Primary renal leiomyosarcoma: A diagnostic challenge. Urol Ann 2012;4:48-50
- Srinivas V, Sogani PC, Hajdu SI, Whitmore WF Jr. Sarcomas of the kidney. J Urol. 1984;132(1):13-6.]
- Iwata J and Fletcher CDM: Immunohistochemical detection of cytokeratin and epithelialmembrane antigen in leiomyosarcoma: A systematic study of 100 cases. Pathology International 2000; 50: 7–14.
- Ozturk H : High-grade Primary Renal Leiomyosarcoma. Int Braz J Urol. 2015; 41: 304-11.
- Weiss SW. Smooth muscle tumors of soft tissue. Adv Anat Pathol. 2002;9:351–359
- Bonvalot S, Gaignard E, Stoeckle E, Meeus P, Decanter G, Carrere S, et al. Survival Benefit of the Surgical Management of Retroperitoneal Sarcoma in a Reference Center: A Nationwide Study of the French Sarcoma Group from the NetSarc Database. Ann Surg Oncol. 2019;26(7):2286-93.
- Lindblad G, Prater S, Chaniotakis SE, Banks J. Inoperable Left Renal Vein Leiomyosarcoma Refractory to Chemotherapy Invades Inferior Vena Cava and Right Atrium: A Case Report. Cureus. 6;13(2):e13182
References
Pham V, Henderson-Jackson E, Doepker MP, Caracciolo JT, Gonzalez RJ, Druta M, et al. Practical issues for retroperitoneal sarcoma. Cancer Control 2016;23(3):249—64.
Messiou C, Morosi C. Imaging in retroperitoneal soft tissue sarcoma. J Surg Oncol 2018;117(1):25—32
Kwon YS, Salmasi A, Han CS, Hon JD, Singer EA. Renal leiomyosarcoma: case report and review of the literature. World J Nephrol Urol. 2015;4:213– 7.
Demir A, Yazici CM, Eren F, Türkeri L. Case report: good prognosis in leiomyosarcoma of the kidney. Int Urol Nephrol. 2007 ;39:7– 10.
Kendal WS. The comparative survival of renal leiomyosarcoma. Can J Urol. 2007 14:3435–42.
Gupta S, Jimenez RE, Folpe AL, Cheville JC. Renal Leiomyoma and leiomyosarcoma: a study of 57 cases. Am J Surg Pathol. 2016 ;40:1557– 63
Beardo P, José Ledo M, Jose Luis RC. Renal leiomyosarcoma. Rare Tumors. (2013) 5:e42.
Deyrup AT, Montgomery E, Fisher C. Leiomyosarcoma of the kidney: a clinicopathologic study. Am J Surg Pathol 2004 : 28: 178-82.
Ouardani ME, Iken A, Sayegh HE. Leiomyosarcome renal (à propos de deux cas). J Maroc Urol 2007; 8: 29-31.
Vasquez Ciriaco S, García Espinoza JA, Garcia Pedro EE. Primary leiomyosarcoma of kidney with metastasis to contralateral kidney. Case report. Interv Med Appl Sci. 2018;10(2):98-101.
Diallo Y, Kouka SC, Ondo CZ, Sow Y, Fall B, Diao B, et al. Un cas de léiomyosarcome rénal géant. Rev. méd. Madag. 2014 ; 4(1) : 382-84
Chen C, Jiang X, Xia F, Chen X and Wang W (2021) Clinicopathological Characteristics and Survival Outcomes of Primary Renal Leiomyosarcoma. Front. Surg. 8:704221.
Moazzam M, Ather MH, Hussainy AS. Leiomyosarcoma presenting as a spontaneously ruptured renal tumor-case report. BMC Urol. 2002 ;2:13.
Dominicia A, Mondainia N, Nesib G, Travaglinia F, Di Celloa V et Rizzoa. Cystic Leiomyosarcoma of the Kidney: An Unusual Clinical Presentation. Urol Int 2000;65:229–31.
Darlington D, Anitha F. Atypical Presentation of Renal Leiomyosarcoma: A Case Report. Cureus 11(8): e5433
Makni, A., Rebai, W., Chebbi, F. Daghfous A, Ayadi S et Ben Safta Z. Cas clinique leiomyosarcome du rein: A propos d’un cas. Afr J Urol ,(2010)16 ;4 134-136
Kurugoglu S, Ogut G, Mihmanli I, Korman U, Durak H. Abdominal leiomyosarcomas: radiologic appearances at various locations. Eur Radiol 2002;12:2933-42.
Merran S, Karila Cohen P, Vieillefond A. Tumeurs retroperitoneales primitives de l’adulte. [Primary retroperitoneal tumors in adults]. J.Radiol. 2004; Feb;85(2 Pt 2):252-64
Dhawan S, Chopra P, Dhawan S. Primary renal leiomyosarcoma: A diagnostic challenge. Urol Ann 2012;4:48-50
Srinivas V, Sogani PC, Hajdu SI, Whitmore WF Jr. Sarcomas of the kidney. J Urol. 1984;132(1):13-6.]
Iwata J and Fletcher CDM: Immunohistochemical detection of cytokeratin and epithelialmembrane antigen in leiomyosarcoma: A systematic study of 100 cases. Pathology International 2000; 50: 7–14.
Ozturk H : High-grade Primary Renal Leiomyosarcoma. Int Braz J Urol. 2015; 41: 304-11.
Weiss SW. Smooth muscle tumors of soft tissue. Adv Anat Pathol. 2002;9:351–359
Bonvalot S, Gaignard E, Stoeckle E, Meeus P, Decanter G, Carrere S, et al. Survival Benefit of the Surgical Management of Retroperitoneal Sarcoma in a Reference Center: A Nationwide Study of the French Sarcoma Group from the NetSarc Database. Ann Surg Oncol. 2019;26(7):2286-93.
Lindblad G, Prater S, Chaniotakis SE, Banks J. Inoperable Left Renal Vein Leiomyosarcoma Refractory to Chemotherapy Invades Inferior Vena Cava and Right Atrium: A Case Report. Cureus. 6;13(2):e13182