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Abstract

SUMMARY
OBJECTIVES: To report the preliminary results of an evaluation of the effects of Ramadan fasting on the metabolic profile of type 2 diabetic patients followed in Ndjamena.
PATIENTS AND METHODS: Prospective observational and analytical study, involving Chadian diabetic type 2 followed as outpatients in the outpatient consultation of Endocrinology - Diabetology department of the National General Reference Hospital (HGRN). They had a clinical evaluation and metabolic profile (glycemic parameters and lipid profile) before and after Ramadan fasting.
RESULTS: There were 56 patients (33 male and 23 female). The mean age was 50 years. 73.2 % were taking monotherapy (sulphonylurea or biguanide), 19.6 % combination therapy (metformin + sulfonylurea) and 7.1% were only on lifestyle and dietary measures. The mean blood glucose dropped from 1.55 +/- 1.01 to 1.43 +/- 0.44 (p < 0.000), while glycated hemoglobin values increased from 7.2 +/- 1.4 to 7, 7 +/- 0.9 (p < 0.000). The mean triglyceride levels increased from 1.2 +/- 0.6 to 1.6 +/- 0.5 g / l (p < 0.000). 3 patients (5.3%) stopped Ramadan fasting prematurely because of hypoglycemia. They were taking glibenclamide.
CONCLUSION: In Chadian outpatients with type 2 diabetes, observed metabolic findings during fasting of Ramadan are an increase in glycated hemoglobin and triglycerides. It is mostly evident among elderly people, and those whose only treatment is lifestyle and dietary measures. Most patients were able to fast without acute metabolic accidents, but, 5.3% were not able to complete their fasting, because of hypoglycemia

RÉSUMÉ
OBJECTIF. Les auteurs rapportent les résultats préliminaires d’une évaluation des effets du jeûne de Ramadan sur le profil métabolique de diabétiques de type 2 suivis en consultation spécialisée à N’Djamena.
PATIENTS ET MÉTHODES. Étude prospective et analytique d’observation étalée sur 03 mois, portant sur 56 diabétiques de type 2 suivis en ambulatoire dans l’unité d’endocrinologie de l’Hôpital Général de référence de Ndjamena. Elle a consisté en une évaluation clinique et biologique, avant et après le Ramadan.
RÉSULTATS. Il y avait 56 patients, dont 33 hommes et 23 femmes. L’âge moyen était de 50 ans. Parmi ces patients 73,2% étaient sous monothérapie (sulfamide ou biguanide), 19,6% sous bithérapie (metformine + sulfamide) et 7,1% sous régime hygiéno- diététique. Les moyennes glycémiques variaient de 1,55 +/- 1,01 à 1,43+/- 0,44 (p < 0,000), tandis que celles d’HbA1c étaient de 7,2+/- 1,4 et 7,7+/- 0,9 (p < 0,000) avant et après le Ramadan. Le taux moyen des triglycérides variait de 1,2 +/-0,6 à 1,6+/-0,5g/l (p < 0,000). 3 patients (5,3%) ont arrêté le Ramadan avant son terme à cause d’une hypoglycémie. Tous les trois étaient sous Glibenclamide.
CONCLUSION. Chez les diabétiques tchadiens, les troubles métaboliques au cours du jeûne de Ramadan étaient marqués par l’augmentation du taux d’hémoglobine glyquée et des triglycérides. Ceux ci pouvaient être minimisés par un bon équilibre avant le Ramadan, surtout chez les personnes âgées. Pour cela les patients devaient être sous traitement médicamenteux et être bien suivis.

Article Details

How to Cite
Dionadji, M., Abdelsalam, T., & Hisseine, A. (2015). Metabolic profile of type 2 diabetic patients before and after Ramadan fasting at an outpatient clinic in N’Djamena. HEALTH SCIENCES AND DISEASE, 16(2). https://doi.org/10.5281/hsd.v16i2.532

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