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Abstract
ABSTRACT
Exposure to carbon monoxide (CO) over long periods is associated with delayed clinical manifestations in exposed subjects. These manifestations include parkinsonian signs which could be mistaken for idiopathic Parkinson’s disease if a thorough medical history is not taken. We present a 55-year-old woman who was hospitalised at 2 weeks following CO exposure with altered behavioural patterns, bilateral pyramidal signs, parkinsonism and abnormal neuro-imaging findings. This case is an example of delayed central nervous system dysfunction secondary to CO exposure highlighting the importance of the clinical observation and raising the issue of brain health and environmental pollution.
RÉSUMÉ
L’exposition au monoxyde de carbone (CO) sur de longues périodes est associée à des manifestations cliniques retardées chez les sujets exposés. Ces manifestations comprennent des signes parkinsoniens qui pourraient être confondus avec la maladie de Parkinson idiopathique si des antécédents médicaux complets ne sont pas pris. Nous présentons une femme de 55 ans qui a été hospitalisée deux semaines après l'exposition au CO avec les troubles de comportement, des signes pyramidaux bilatéraux, syndrome parkinsonien et des signes de neuro-imagerie anormaux. Ce cas est un exemple de manifestations neurologiques retardées du système nerveux central secondaires à l'exposition au CO, soulignant l'importance de l'observation clinique et soulevant la question de la santé du cerveau et de la pollution de l'environnement.
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References
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- Penney D, Benignus V, Kephalopoulos S, Kotzias D, Kleinman M, Verrier A. Carbon monoxide [Internet]. World Health Organization; 2010 [cited 2018 Jan 16]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK138710/
- Bruno A, Wagner W, Orrison WW. Clinical outcome and brain MRI four years after carbon monoxide intoxication. Acta Neurol Scand. 1993;87(3):205–9.
- Laties VG, Merigan WH. Behavioral effects of carbon monoxide on animals and man. Annu Rev Pharmacol Toxicol. 1979;19(1):357–92.
- Quinn DK, McGahee SM, Politte LC, Duncan GN, Cusin C, Hopwood CJ, et al. Complications of carbon monoxide poisoning: a case discussion and review of the literature. Prim Care Companion J Clin Psychiatry. 2009;11(2):74.
- Hardy KR, Thom SR. Pathophysiology and treatment of carbon monoxide poisoning. J Toxicol Clin Toxicol. 1994;32(6):613–29.
- Devine SA, Kirkley SM, Palumbo CL, White RF. MRI and neuropsychological correlates of carbon monoxide exposure: a case report. Environ Health Perspect. 2002 Oct;110(10):1051–5.
- Choi IS. Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol. 1983 Jul;40(7):433–5.
- Hampson NB, Piantadosi CA, Thom SR, Weaver LK. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med. 2012 Dec 1;186(11):1095–101.
- Lee MS, Marsden CD. Neurological sequelae following carbon monoxide poisoning clinical course and outcome according to the clinical types and brain computed tomography scan findings. Mov Disord. 1994;9(5):550–8.
- Chang KH, Han MH, Kim HS, Wie BA, Han MC. Delayed encephalopathy after acute carbon monoxide intoxication: MR imaging features and distribution of cerebral white matter lesions. Radiology. 1992;184(1):117–22.
- Betterman K, Patel S. Neurologic complications of carbon monoxide intoxication. Handb Clin Neurol. 2014;120:971–9.
- Weaver LK. Carbon monoxide poisoning. N Engl J Med. 2009;360(12):1217–25.
- Vieregge P, Klostermann W, Blümm RG, Borgis KJ. Carbon monoxide poisoning: clinical, neurophysiological, and brain imaging observations in acute disease and follow-up. J Neurol. 1989;236(8):478–81.
- Zagami AS, Lethlean AK, Mellick R. Delayed neurological deterioration following carbon monoxide poisoning: MRI findings. J Neurol. 1993;240(2):113–6.
- Uchino A, Hasuo K, Shida K, Matsumoto S, Yasumori K, Masuda K. MRI of the brain in chronic carbon monoxide poisoning. Neuroradiology. 1994;36(5):399–401.
- Hampson NB. Emergency department visits for carbon monoxide poisoning in the Pacific Northwest. J Emerg Med. 1998;16(5):695–8.
- Hampson NB. U.S. Mortality Due to Carbon Monoxide Poisoning, 1999-2014. Accidental and Intentional Deaths. Ann Am Thorac Soc. 2016 Oct;13(10):1768–74.
- Mott JA, Wolfe MI, Alverson CJ, Macdonald SC, Bailey CR, Ball LB, et al. National vehicle emissions policies and practices and declining US carbon monoxide-related mortality. JAMA. 2002 Aug 28;288(8):988–95.
- Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 2002;347(14):1057–67.
- Olson KR. Carbon monoxide. Poisoning Drug Overdose Fifth Ed N Y NY McGraw-Hill. 2007;
- Ginsburg R, Romano J. Carbon monoxide encephalopathy: need for appropriate treatment. Am J Psychiatry. 1976;
- Wolf SJ, Lavonas EJ, Sloan EP, Jagoda AS. Clinical policy: critical issues in the management of adult patients presenting to the emergency department with acute carbon monoxide poisoning. J Emerg Nurs. 2008;34(2):e19–32.
- Juurlink DN, Buckley NA, Stanbrook MB, Isbister GK, Bennett M, McGuigan MA. Hyperbaric oxygen for carbon
References
Lane TR, Williamson WJ, Brostoff JM. Carbon monoxide poisoning in a patient with carbon dioxide retention: a therapeutic challenge. Cases J. 2008 Aug 18;1:102.
Penney D, Benignus V, Kephalopoulos S, Kotzias D, Kleinman M, Verrier A. Carbon monoxide [Internet]. World Health Organization; 2010 [cited 2018 Jan 16]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK138710/
Bruno A, Wagner W, Orrison WW. Clinical outcome and brain MRI four years after carbon monoxide intoxication. Acta Neurol Scand. 1993;87(3):205–9.
Laties VG, Merigan WH. Behavioral effects of carbon monoxide on animals and man. Annu Rev Pharmacol Toxicol. 1979;19(1):357–92.
Quinn DK, McGahee SM, Politte LC, Duncan GN, Cusin C, Hopwood CJ, et al. Complications of carbon monoxide poisoning: a case discussion and review of the literature. Prim Care Companion J Clin Psychiatry. 2009;11(2):74.
Hardy KR, Thom SR. Pathophysiology and treatment of carbon monoxide poisoning. J Toxicol Clin Toxicol. 1994;32(6):613–29.
Devine SA, Kirkley SM, Palumbo CL, White RF. MRI and neuropsychological correlates of carbon monoxide exposure: a case report. Environ Health Perspect. 2002 Oct;110(10):1051–5.
Choi IS. Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol. 1983 Jul;40(7):433–5.
Hampson NB, Piantadosi CA, Thom SR, Weaver LK. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med. 2012 Dec 1;186(11):1095–101.
Lee MS, Marsden CD. Neurological sequelae following carbon monoxide poisoning clinical course and outcome according to the clinical types and brain computed tomography scan findings. Mov Disord. 1994;9(5):550–8.
Chang KH, Han MH, Kim HS, Wie BA, Han MC. Delayed encephalopathy after acute carbon monoxide intoxication: MR imaging features and distribution of cerebral white matter lesions. Radiology. 1992;184(1):117–22.
Betterman K, Patel S. Neurologic complications of carbon monoxide intoxication. Handb Clin Neurol. 2014;120:971–9.
Weaver LK. Carbon monoxide poisoning. N Engl J Med. 2009;360(12):1217–25.
Vieregge P, Klostermann W, Blümm RG, Borgis KJ. Carbon monoxide poisoning: clinical, neurophysiological, and brain imaging observations in acute disease and follow-up. J Neurol. 1989;236(8):478–81.
Zagami AS, Lethlean AK, Mellick R. Delayed neurological deterioration following carbon monoxide poisoning: MRI findings. J Neurol. 1993;240(2):113–6.
Uchino A, Hasuo K, Shida K, Matsumoto S, Yasumori K, Masuda K. MRI of the brain in chronic carbon monoxide poisoning. Neuroradiology. 1994;36(5):399–401.
Hampson NB. Emergency department visits for carbon monoxide poisoning in the Pacific Northwest. J Emerg Med. 1998;16(5):695–8.
Hampson NB. U.S. Mortality Due to Carbon Monoxide Poisoning, 1999-2014. Accidental and Intentional Deaths. Ann Am Thorac Soc. 2016 Oct;13(10):1768–74.
Mott JA, Wolfe MI, Alverson CJ, Macdonald SC, Bailey CR, Ball LB, et al. National vehicle emissions policies and practices and declining US carbon monoxide-related mortality. JAMA. 2002 Aug 28;288(8):988–95.
Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 2002;347(14):1057–67.
Olson KR. Carbon monoxide. Poisoning Drug Overdose Fifth Ed N Y NY McGraw-Hill. 2007;
Ginsburg R, Romano J. Carbon monoxide encephalopathy: need for appropriate treatment. Am J Psychiatry. 1976;
Wolf SJ, Lavonas EJ, Sloan EP, Jagoda AS. Clinical policy: critical issues in the management of adult patients presenting to the emergency department with acute carbon monoxide poisoning. J Emerg Nurs. 2008;34(2):e19–32.
Juurlink DN, Buckley NA, Stanbrook MB, Isbister GK, Bennett M, McGuigan MA. Hyperbaric oxygen for carbon