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RÉSUMÉ
Introduction. Le cancer de la prostate occupe la 5e place des cancers dans le monde. Au stade métastatique, la suppression androgénique demeure la base du traitement. A l’heure où l’utilisation des analogues de la LHRH est répandue, leurs effets secondaires et leurs coûts imposent de reconsidérer la place à accorder à la castration chirurgicale en zone peu développée. L’objectif était d’apprécier l’impact de la castration chirurgicale dans la prise en charge des cancers métastatiques dans notre contexte. Méthodologie. Nous avons réalisé une étude rétrospective et descriptive au Centre Hospitalier et universitaire de Yaoundé de Janvier 2016 au 31 Décembre 2017. Résultats. Nous avons retenu 08 dossiers. L’âge médian était de 72,5 ans. En phase pré-opératoire, les principales plaintes étaient les douleurs osseuses (62,5%), les signes urinaires (50%), et des signes respiratoires (25%). Le taux de PSA médian était de 1050 ng/ml. Le score de Gleason variait entre 7 et 9, le stade TxNxM1b était le plus fréquent. Toutes les interventions ont été faites sous anesthésie locale. Le ratio traitement chirurgical/ médical variait de 0,016 à 0,091. En phase post opératoire on notait un amendement de la symptomatologie en dehors des signes respiratoires. Le taux de PSA avait diminué avec une valeur médiane de 7 ng/ml. La qualité de vie était jugée satisfaisante dans 75% des cas. Nous avons enregistré le décès de 02 patients dans le mois qui a suivi leur intervention. Conclusion. La castration chirurgicale améliore l’état général et la symptomatologie. Elle est une option de choix dans notre contexte socio-économique.
ABSTRACT
Background. Prostate cancer ranks 5th among cancers in the world. At the metastastic stage, androgen suppression remains the basis of treatment. At a time when the use of LHRH analogues is widespread, their side effects and their costs make it necessary to reconsider the place to be given to surgical castration in underdeveloped areas. The objective was to appreciate the impact of surgical castration in the management of metastatic cancers in our context. Methods. We carried out a retrospective and descriptive study at the Yaounde University Hospital Center from January 2016 to December 31, 2017. Results. We retained 08 files. The median age was 72.5 years. In the preoperative phase The main complaints were bone pain (62.5%), urinary signs (50%), and respiratory signs (25%). The median PSA level was 1050 ng / ml. The Gleason score varied between 7 and 9, the TxNxM1b stage was the most frequent. All procedures were performed under local anesthesia. The surgical / medical treatment ratio ranged from 0.016 to 0.091. In the postoperative phase there was an improvement in the symptomatology apart from the respiratory signs. The PSA level had decreased with a median value of 7 ng / ml. The quality of life was considered satisfactory in 75% of the cases. We recorded the deaths of 02 patients in the month following their intervention. Conclusion. Surgical castration improves the general condition and the symptomatology. It is an option of choice in our socio-economic context.

Article Details

Author Biography

Freddy Bombah, FMBS

Medical Imaging
How to Cite
Biongolo, F., Bombah, F., Mama, V. de P., Mebara, Z., & Ngo Nonga, B. (2020). La Castration Chirurgicale dans la Prise en Charge des Cancers Métastatiques de la Prostate à Yaoundé. HEALTH SCIENCES AND DISEASE, 21(7). https://doi.org/10.5281/hsd.v21i7.2120
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