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Abstract
Les tumeurs malignes de la vésicule biliaire sont extrêmement rares et ne sont qu’exceptionnellement diagnostiquées à un stade précoce. Nous rapportons un cas d’adénocarcinome de la vésicule biliaire survenu chez un patient de 60 ans, avec des symptômes et des examens paracliniques peu évocateurs et dont l’examen anatomopathologique de la pièce chirurgicale a documenté un adénocarcinome invasif peu différencié, avec infiltration de toute la paroi de la vésicule biliaire avec atteinte de la séreuse sans dépassement. Cette tumeur a été classée stade pT3 selon la classification TNM. Notre cas d’adénocarcinome de la vésicule biliaire documenté à l’anatomopathologie, avait des symptômes et des examens paracliniques peu spécifiques.
ABSTRACT
Gallbladder cancers are extremely rare and are exceptionally diagnosed at an early stage. We report a case of gallbladder adenocarcinoma that occurred in a 60-year-old patient, with symptoms and paraclinical examinations that were not very evocative and whose anatomopathological examination of the surgical specimen documented a poorly differentiated invasive adenocarcinoma, with infiltration of the entire wall of the gallbladder with damage to the serosa without protrusion. This tumour was classified as stage pT3 according to the TNM classification. Our case of gallbladder adenocarcinoma documented in pathology, had symptoms and paraclinical examinations that were not very specific.
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References
- Miller G., Jarnaging W.R. Gallbladder carcinoma. The journal of cancer surgery, 34(2008) 306-318
- Lazcano-Ponce EC, Miquel JF, Muñoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA: Cancer J Clin. 2001. 2001;51(6):349–64
- Ibrahima Ka, Magatte Faye, Papa Saloum Diop, Amadou Bocar Niang Aliou Coly Faye, Jean Marc Ndoye, Babacar Fall. Cancers biliaires: aspects épidémiologiques cliniques et thérapeutiques à propos de 20 cas. Pan Afr Med J. 2018; 29: 13
- Konstantinidis IT, Deshpande V, Genevay M, et al. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg. 2009;144(5): 441–7
- de Aretxabala X, Roa I, Burgos L, et al. Gallbladder cancer: an analysis of a series of 139 patients with invasion restricted to the subserosal layer. J Gastrointest Surg 2006;10:186–92.
- Tazuma S, Kajiyama G. Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones. Langenbecks Arch Surg 2001;386:224–9.
- Yang HL, Sun YG, Wang Z. Polypoid lesions of the gallbladder: diagnosis and indications for surgery. Br J Surg 1992;79:227–9.
- Rekika W, Ben Fadhela C, Boufarouaa AL, Mestiri H, Khalfallah MT, Bouraouia S, Mzabi-Rgayaa S. Case report: Primary pure squamous cell carcinoma of the gallbladder. Journal of Visceral Surgery. 2011 Apr;148(2):149-51.
- Eckel F, Schmid RM. Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 2007;96:896–902
- Gondos A, Brenner H, Wabinga H, Parkin DM. Cancer survival in Kampala, Uganda. Br J Cancer. 2005;92(9):1808–12
References
Miller G., Jarnaging W.R. Gallbladder carcinoma. The journal of cancer surgery, 34(2008) 306-318
Lazcano-Ponce EC, Miquel JF, Muñoz N, et al. Epidemiology and molecular pathology of gallbladder cancer. CA: Cancer J Clin. 2001. 2001;51(6):349–64
Ibrahima Ka, Magatte Faye, Papa Saloum Diop, Amadou Bocar Niang Aliou Coly Faye, Jean Marc Ndoye, Babacar Fall. Cancers biliaires: aspects épidémiologiques cliniques et thérapeutiques à propos de 20 cas. Pan Afr Med J. 2018; 29: 13
Konstantinidis IT, Deshpande V, Genevay M, et al. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg. 2009;144(5): 441–7
de Aretxabala X, Roa I, Burgos L, et al. Gallbladder cancer: an analysis of a series of 139 patients with invasion restricted to the subserosal layer. J Gastrointest Surg 2006;10:186–92.
Tazuma S, Kajiyama G. Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones. Langenbecks Arch Surg 2001;386:224–9.
Yang HL, Sun YG, Wang Z. Polypoid lesions of the gallbladder: diagnosis and indications for surgery. Br J Surg 1992;79:227–9.
Rekika W, Ben Fadhela C, Boufarouaa AL, Mestiri H, Khalfallah MT, Bouraouia S, Mzabi-Rgayaa S. Case report: Primary pure squamous cell carcinoma of the gallbladder. Journal of Visceral Surgery. 2011 Apr;148(2):149-51.
Eckel F, Schmid RM. Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials. Br J Cancer 2007;96:896–902
Gondos A, Brenner H, Wabinga H, Parkin DM. Cancer survival in Kampala, Uganda. Br J Cancer. 2005;92(9):1808–12