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Abstract

RÉSUMÉ  
L’ostéomalacie est un défaut de minéralisation osseuse. Elle peut être d’étiologie multifactorielle. Nous rapportons l’observation d’une patiente de 52 ans, hospitalisée pour des douleurs osseuses diffuses évoluant depuis un an. Suivie pour une infection par le VIH depuis 10 ans, elle était traitée par une trithérapie associant le Tenofovir, l’Efavirenz et la Lavimudine depuis 6 ans. Elle a présenté une perturbation du métabolisme phospho-calcique et des anomalies osseuses telles que des pseudo fractures, rattachées à une ostéomalacie secondaire à un syndrome de Fanconi favorisé par le tenofovir.
 
ABSTRACT
Osteomalacia is a defect in bone mineralization. It can be of multifactorial aetiologies. We report the case of 52 year-old patient, hospitalized for diffuse bone pain evolving for one year. Followed for an HIV infection since 10 years, she had been treated with triple therapy combining Tenofovir, Efavirenz and Lamivudine for 6 years. She presented a disturbance of calcium phosphate metabolism and bone abnormalities such as pseudo fractures, related to osteomalacia secondary to Fanconi syndrome. Fanconi syndrome was induced by long course treatment with Tenofovir.

Keywords

Ostéomalacie, Tenofovir, Syndrome de Fanconi Osteomalacia, Tenofovir, Fanconi syndrome

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Fojo TB, Tamko CW, Pelda A, Anaba MY, Ndzana V, Zoyem P, Nkeck JR, Ngoufack TC, Tchouanlong A, Kemnang YH, & Singwé-Ngandeu M. (2023). Ostéomalacie Secondaire à un Syndrome de Fanconi chez une Patiente Vivant avec le VIH Traitée par le Tenofovir. HEALTH SCIENCES AND DISEASE, 24(8). https://doi.org/10.5281/hsd.v24i8.4769
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References

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