Facteurs Associés au Portage de l’AgHbs en Grossesse dans un Pays de Haute Endémicité : Une Étude Cas-Témoin

Valère Mve Koh, Christian Wambo Nguessi, Felix Essiben, Emile Télesphore Mboudou

Abstract



RÉSUMÉ
Objectif. L’objectif était d’évaluer les facteurs associés au portage de l’aghbs en grossesse afin d’identifier des cibles de prévention. Matériels et méthodes. Il s’agit d’une étude cas témoin réalisée dans trois hôpitaux universitaires de Douala et Yaoundé. Les cas étaient constitués de femmes enceintes avec une sérologie AgHBs positive. Nous avons recruté 121 femmes enceintes Ag HBs positifs et les avons appariées à 242 mères Ag HBs négatifs après régression logistique. Résultats. Les facteurs associés au portage de l’AgHBs en grossesses étaient l’union libre [OR : 5,01 IC 95% (2,51-10,02) p=0,001 ]; la religion pentecôtiste [OR 4,3 IC 95% (1,41-13,47) p=0,01]; les antécédents d’ictère [OR : 5,3 IC 95% (1,20-23,37) p=0,02 ]; de soins dentaires [OR : 2,4 IC 95% (2,26-4,96) p=0,01 ]; et de scarifications [OR 7,4 IC 95% (3,77-14,58) p=0,00], l’hépatite B dans l’entourage [OR : 4,86 IC 95% (1,20-19,65) p=0,02] et l’antécédent familial d’infection à l’hépatite B au premier degré [OR : 7,08 IC 95% (1,44-34,78) p=0,01]. Conclusion. Plusieurs facteurs associés à l’hépatite B en grossesse précédemment identifiés dans la littérature récente ont été retrouvés. Le rôle des congrégations pentecôtistes, donnée spécifique de notre travail reste à confirmer.
ABSTRACT
Objective. The objective of the study was to evaluate sociodemographic and clinical factors associated to hepatitis B surface antigen in pregnancy so as to identify potential preventive targets. Materials and methods. It was a case-control study conducted in three university teaching hospital of Douala and Yaoundé. Cases were AgHBs positive pregnant women and the control were AgHBs negative. We included 121 AgHBs positive pregnant women and 242 controls. Results. After logistic regression, factors associated to hepatitis B in pregnancy were co-habitation [OR : 5.01 CI 95% (2.51-10.02) p=0.001 ]; pentecostalism, [OR 4.3 CI 95% (1.41-13.47) p=0.01]; past histories of jaundice [OR : 5.3 CI 95% (1.20-23.37) p=0.02 ]; dental care [OR : 2.4 CI 95% (2.26-4.96) p=0.01 ]; scarifications [OR 7.4 CI 95% (3.77-14.58) p=0.001]. history of hepatitis B among entourage [OR: 4.86 CI 95% (1.20-19.65) p=0.02] and past history of hepatitis B among first degree siblings [OR: 7.08 CI 95% (1.44-34.78) p=0,01]. Conclusion. Several factors associated to HBsAg positive profile identified in recent literature were confirmed. The relationship with pentecostalism, a specific finding of this study has to be confirmed by more studies.

 


Keywords


Facteurs associés, Hépatite B et grossesse, Douala.

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