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Abstract
RÉSUMÉ
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a complex, multi-facial disease that involves viral, inflammatory, and thrombotic phases. We report a picture of a pulmonary heart in a young overweight subject under combined estrogen-progestin contraception. Paraclinical examinations find parameters of overload of the right cavities and myocardial lesions responsible for troponin elevation, inflammatory syndrome, and severe hypoxemia. Computed tomography pulmonary angiogram showed a bilateral pulmonary embolism associated with COVID-19 pneumonia and deep femoral thrombosis on Doppler ultrasound of the limbs. SARS-CoV-2 infection was confirmed. The patient was then put on oxygen and adequate treatment leading to a favorable evolution. The management of acute cor pulmonale in COVID-19 is a challenge because it requires a multidisciplinary team.
ABSTRACT
L’infection à ‘’Severe acute respiratory syndrome coronavirus 2’’ (SARS-CoV-2) est une maladie complexe à plusieurs visages qui implique des phases virales, inflammatoires et thrombotiques. Nous rapportons le tableau de cœur pulmonaire chez un jeune sujet en surpoids sous contraception œstrogène-progestative. Les examens paracliniques trouvent des indices de surcharge des cavités droites et des lésions myocardiques responsables de l’élévation de la troponine, du syndrome inflammatoire et de l’hypoxémie sévère. L’angio-tomodensitométrie pulmonaire a montré une embolie pulmonaire bilatérale associée à une pneumonie de COVID-19 et à une thrombose fémorale profonde à l’échographie Doppler des membres. L’infection par le SRAS-CoV-2 a été confirmée. Le patient a ensuite été mis sous oxygène et un traitement adéquat conduisant à une évolution favorable. La prise en charge du cœur pulmonaire aigu dans la COVID-19 est un défi car elle nécessite une équipe multidisciplinaire.
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References
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- - Fei Zhou et al.: Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020. doi.org/10.1016/ S0140-6736(20)30566-3
- - Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent un necessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost 2004;2:1247_1255
- - Fauvel C, Weizman O, Trimaille A, Mika D, Pommier T, Pace N, et al. Pulmonaryembolism in COVID-19 patients: a French multicentre cohort study. Eur HeartJ 2020;41:3058–68.
- - Jime ́nez D, Aujesky D, Moores L, Go ́mez V, Lobo JL, Uresandi F, Otero R, Monreal M, Muriel A, YusenRD. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med 2010;170(15):1383–1389
- - Kuno T, Takahashi M, Obata R, Maeda T. Cardiovascular comorbidities, cardiac injury and prognosis of COVID-19 in New York City. Am Heart J 2020;226:24–5
- - Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 2020;5:802–10
- - Gupta N, Zhao Y-Y, Evans C.E. (2019). The stimulation of thrombosis by hypoxia. thrombosis research, 181, 77-83
- - Messika J, Goutorbe P, Hajage D, Ricard JD. Severe pulmonary embolism managed with high-flow nasal cannula oxygen therapy. Eur J Emerg Med 2017;24:230_232.
- - Mercat A, Diehl JL, Meyer G, Teboul JL, Sors H. Hemodynamic effects of fluid loading in acute massive pulmonary embolism. Crit Care Med 1999;27(3):540–544
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References
- Bonny V, Maillard A, Mousseaux C, Plaçais L, Richier Q. COVID-19 : physiopathologie d’une maladie à plusieurs visages [COVID-19: Pathogenesis of a multi-faceted disease]. Rev Med Interne. 2020 Jun;41(6):375-389. French. doi: 10.1016/j.revmed.2020.05.003. Epub 2020 May 27. PMID: 32507520; PMCID: PMC7250743.
- [Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extra-pulmonary manifestations of COVID-19. Nat Med 2020;26:1017–32]
- Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention,antithrombotic therapy, and follow-up. J Am Coll Cardiol 2020;75:2950–73.
- Maatman TK, Jalali F, Feizpour C, Douglas A, McGuire SP, Kinnaman G, et al. Routine venous thromboembolism prophylaxis may be inadequate in thehypercoagulable state of severe coronavirus disease 2019. Crit Care Med2020;48:e783–90.
- Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, KantKM, et al. Incidence of thrombotic complications in critically ill ICU patientswith COVID-19. Thromb Res 2020;191:145–7.
- Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X,et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: amulticenter prospective cohort study. Intensive Care Med 2020;46:1089–98.
- Wei, W.E., Li, Z., Chiew, C.J., Yong, S.E., Toh, M.P. and Lee, V.J., 2020. Presymptomatic Transmission of SARS-CoV-2—Singapore, January 23–March 16, 2020. Morbidity and Mortality Weekly Report, 69(14), p. 411
- Li Y, Yao L, Li J et al. Stability issues of RT-PCR testing of SARSCoV-2 for hospitalized patients clinically diagnosed with Covid-19. J Med Virol. 2020; 1-6.
- Schweblin C, Hachulla AL, Roffi M, Glauser F. Delayed manifestation of COVID-19 presenting as lower extremity multilevel arterial thrombosis: a case report. Eur Heart J Case Rep. 2020 Nov 19;4(6):1-4. doi: 10.1093/ehjcr/ytaa371. PMID: 33437919; PMCID: PMC7717202.
- Veyre F, Poulain-Veyre C, Esparcieux A, Monsarrat N, Aouifi A, Lapeze J, Chatelard P. Femoral Arterial Thrombosis in a Young Adult after Nonsevere COVID-19. Ann Vasc Surg. 2020 Nov;69:85-88. doi: 10.1016/j.avsg.2020.07.013. Epub 2020 Jul 28. PMID: 32736027; PMCID: PMC7386281.
- Santosa YP, Yuwono A. Two Different Clinical Presentations of Acute Limb Ischemia Caused by Acute Thrombotic Events in COVID-19. Cureus. 2021 Sep 12;13(9):e17916. doi: 10.7759/cureus.17916. PMID: 34660110; PMCID: PMC8511142.
- Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications in COVID-19. Am J Emerg Med 2020;38:1504–7
- Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS, China Medical Treatment Expert Group for C. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020.
- Mazzaccaro D, Giannetta M, Fancoli F, Milani V, Modafferi A, Malacrida G, Righini P, Marrocco-Trischitta MM, Nano G. COVID and venous thrombosis: systematic review of literature. J Cardiovasc Surg (Torino). 2021 Sep 14. doi: 10.23736/S0021-9509.21.12022-1. Epub ahead of print. PMID: 34520137.
- Da Costa Rodrigues J, Alzuphar S, Combescure C, Le Gal G, Perrier A. Diagnostic characteristics of lower limb venous compression ultrasonography in suspected pulmonary embolism: a meta-analysis. J Thromb Haemost 2016;14:1765_1772
- Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA. Pulmonary embolism. Nat Rev Dis Primers 2018;4:18028
- Raad, M. et al. Right Heart Strain on ECG in COVID-19. J Am Coll Cardiol EP. 2021; 7 (4): 485–93
- Fei Zhou et al.: Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020. doi.org/10.1016/ S0140-6736(20)30566-3
- Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent un necessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost 2004;2:1247_1255
- Fauvel C, Weizman O, Trimaille A, Mika D, Pommier T, Pace N, et al. Pulmonaryembolism in COVID-19 patients: a French multicentre cohort study. Eur HeartJ 2020;41:3058–68.
- Jime ́nez D, Aujesky D, Moores L, Go ́mez V, Lobo JL, Uresandi F, Otero R, Monreal M, Muriel A, YusenRD. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med 2010;170(15):1383–1389
- Kuno T, Takahashi M, Obata R, Maeda T. Cardiovascular comorbidities, cardiac injury and prognosis of COVID-19 in New York City. Am Heart J 2020;226:24–5
- Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 2020;5:802–10
- Gupta N, Zhao Y-Y, Evans C.E. (2019). The stimulation of thrombosis by hypoxia. thrombosis research, 181, 77-83
- Messika J, Goutorbe P, Hajage D, Ricard JD. Severe pulmonary embolism managed with high-flow nasal cannula oxygen therapy. Eur J Emerg Med 2017;24:230_232.
- Mercat A, Diehl JL, Meyer G, Teboul JL, Sors H. Hemodynamic effects of fluid loading in acute massive pulmonary embolism. Crit Care Med 1999;27(3):540–544
- Samama MM, Poller L. Contemporary laboratory monitoring of low molecularweight heparins. Clin Lab Med 1995;15(1):119–123. .