Mortalité par Accident Vasculaire Cérébral et ses déterminants dans un Hôpital de référence de Douala (Cameroun)

Kuate-Tegueu Callixte; Mapoure-Njankouo Yacouba; Gopdjim-Massu Lauriane; Doumbe Jacques; Noubissi-Dada Gustave; Dissongo Jean II; Djientcheu Vincent de Paul

doi:10.5281/hsd.v17i1.585

Download

PDF (Français (Canada)) Untitled (Français (Canada))

Abstract

Introduction: stroke is reported to be the third cause of death worldwide. Many studies have showed that their case-fatality rate is very high, especially in sub-Saharan Africa. There have been few studies on stroke mortality and its determinants in Cameroon. This study examines the vital and functional prognosis of stroke and its determinants in a tertiary care hospital in Cameroon. Methodology: A prospective study was carried out for six months at the Douala Laquintinie Hospital. Patients with a diagnosis of stroke, with CT-Scan confirmation were recruited and followed up during hospitalization, at one and three months. The deaths and predictors were recorded. Multivariate logistic regression was used to identify independent predictors of mortality.Results: Mean age of the 120 patients (53% male) was 60.5 ± 12.78 years. The case fatality rate was 26.7% at one month and 31.7% at 3 months. On multivariate analysis, the predictors of mortality were Glasgow coma scale less than 8/15 (P = 0.001), a modified Rankin score greater than 5 (P = 0.001), a white blood cell count greater than 10,000 / mm3 (P = 0.004) and a pneumonia (P = 0.001).Conclusion: Despite the young age of our patients, the case fatality rate was very high. Predictors of mortality were co-morbid conditions that can easily be treated if well-diagnosed.

Author Biographies

Kuate-Tegueu Callixte, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1

Département de Médecine Interne et Spécialités

Mapoure-Njankouo Yacouba, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala

Département des Sciences Cliniques

Doumbe Jacques, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala

Département des Sciences Cliniques

Djientcheu Vincent de Paul, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, Cameroun

Département de Chirurgie et Spécialités

How to Cite

Callixte, K.-T., Yacouba, M.-N., Lauriane, G.-M., Jacques, D., Gustave, N.-D., Jean II, D., & Vincent de Paul, D. (2016). Mortalité par Accident Vasculaire Cérébral et ses déterminants dans un Hôpital de référence de Douala (Cameroun). HEALTH SCIENCES AND DISEASE, 17(1). https://doi.org/10.5281/hsd.v17i1.585

Download Citation

References

Zuber M, Mas JL. [Epidemiology of cerebrovascular accidents]. Rev Neurol (Paris). 1992;148(4):243–55.
Lavallée PC, Labreuche J, Spieler J-F, Jougla E, Amarenco P. Stroke and vascular mortality trends in France: 1979-2001. Neuroepidemiology. 2007;29(1-2):78–82.
Redon J, Olsen MH, Cooper RS, Zurriaga O, Martinez-Beneito MA, Laurent S, et al. Stroke mortality and trends from 1990 to 2006 in 39 countries from Europe and Central Asia: implications for control of high blood pressure. Eur Heart J. 2011 Jun;32(11):1424–31.
WHO publishes definitive atlas on global heart disease and stroke epidemic. Indian J Med Sci. 2004 Sep;58(9):405–6.
Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet. 2003 Oct 11;362(9391):1211–24.
Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, et al. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004 Feb;35(2):426–31.
Connor MD, Walker R, Modi G, Warlow CP. Burden of stroke in black populations in sub-Saharan Africa. Lancet Neurol. 2007 Mar;6(3):269–78.
Mapoure NY, Tchaleu Nguenkam CB, Mbatchou Ngahane HB, Dzudie A, Coulibaly A, Mounjouopou NG, et al. Predictors of in-hospital mortality for stroke in Douala, Cameroon. Stroke Res Treat. 2014;2014:681209.
Obiako O, Ogunniyi A, Oparah S. Prognosis and outcome of acute stroke in the University College Hospital Ibadan, Nigeria. Niger J Clin Pract. 2011;14(3):359.
Komolafe MA, Ogunlade O, Komolafe EO. Stroke mortality in a teaching hospital in South Western Nigeria. Trop Doct. 2007 Jul;37(3):186–8.
Beyiha Q, Minkande E, Binam F, Sosso MA. Aspects épidémiologiques et facteurs de gravité des accidents vasculaires cérébraux au Cameroun. J Maghréb Anesth-Réanimation Médecine Urgence. 2008;15(66):293–7.
Cochran WG. Some Methods for Strengthening the Common χ2 Tests. Biometrics. 1954;10(4):417–51.
Armitage P. Tests for Linear Trends in Proportions and Frequencies. Biometrics. 1955;11(3):375–86.
Touré K, Diagne SN, Seck BL, others. Predictors of stroke mortality at the department of neurology, fann university teaching hospital, Dakar-Senegal. Afr J Neurol Sci. 2010;29(2):325–34.
Walker RW, Rolfe M, Kelly PJ, George MO, James OFW. Mortality and recovery after stroke in the Gambia. Stroke. 2003 Jul;34(7):1604–9.
Nkoke C, Lekoubou A, Balti E, Kengne AP. Stroke mortality and its determinants in a resource-limited setting: A prospective cohort study in Yaounde, Cameroon. J Neurol Sci. 2015 Nov 15;358(1-2):113–7.
Saposnik G, Jeerakathil T, Selchen D, Baibergenova A, Hachinski V, Kapral MK, et al. Socioeconomic status, hospital volume, and stroke fatality in Canada. Stroke. 2008 Dec;39(12):3360–6.
Ogbu UC, Westert GP, Slobbe LCJ, Stronks K, Arah OA. A multifaceted look at time of admission and its impact on case-fatality among a cohort of ischaemic stroke patients. J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):8–13.
Andersen KK, Andersen ZJ, Olsen TS. Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke. Stroke. 2011 Oct;42(10):2806–12.
Bhalla A, Gupta OP, Gupta SB. Predicting mortality in stroke. Neurol India. 2002 Sep;50(3):279–81.
Yilmaz C, Kabatas S, Gulsen S, Cansever T, Gurkanlar D, Caner H, et al. Spontaneous supratentorial intracerebral hemorrhage: Does surgery benefit comatose patients? Ann Indian Acad Neurol. 2010 Jul;13(3):184–7.
Lekoubou A, Nkoke C, Dzudie A, Kengne AP. Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: A fourteen year trend study from 1999 to 2012. J Neurol Sci. 2015 Mar 15;350(1–2):24–32.
Hårdemark HG, Wesslén N, Persson L. Influence of clinical factors, CT findings and early management on outcome in supratentorial intracerebral hemorrhage. Cerebrovasc Dis. 1999 Feb;9(1):10–21.
Kim J, Song T-J, Park JH, Lee HS, Nam CM, Nam HS, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012 Jun;222(2):464–7.
Zia E, Engström G, Svensson PJ, Norrving B, Pessah-Rasmussen H. Three-year survival and stroke recurrence rates in patients with primary intracerebral hemorrhage. Stroke. 2009 Nov;40(11):3567–73.
Ekeh B, Ogunniyi A, Isamade E, Ekrikpo U. Stroke mortality and its predictors in a Nigerian teaching hospital. Afr Health Sci. 2015 Mar;15(1):74–81.
Desalu OO, Wahab KW, Fawale B, Olarenwaju TO, Busari OA, Adekoya AO, et al. A review of stroke admissions at a tertiary hospital in rural Southwestern Nigeria. Ann Afr Med. 2011 Jun;10(2):80–5.
Garbusinski JM, van der Sande MAB, Bartholome EJ, Dramaix M, Gaye A, Coleman R, et al. Stroke presentation and outcome in developing countries: a prospective study in the Gambia. Stroke. 2005 Jul;36(7):1388–93.
Sène Diouf F, Basse AM, Ndao AK, Ndiaye M, Touré K, Thiam A, et al. Pronostic fonctionnel des accidents vasculaires cérébraux dans les pays en voie de développement : Sénégal. Ann Réadapt Médecine Phys. 2006 Apr;49(3):100–4.

References

Zuber M, Mas JL. [Epidemiology of cerebrovascular accidents]. Rev Neurol (Paris). 1992;148(4):243–55.

Lavallée PC, Labreuche J, Spieler J-F, Jougla E, Amarenco P. Stroke and vascular mortality trends in France: 1979-2001. Neuroepidemiology. 2007;29(1-2):78–82.

Redon J, Olsen MH, Cooper RS, Zurriaga O, Martinez-Beneito MA, Laurent S, et al. Stroke mortality and trends from 1990 to 2006 in 39 countries from Europe and Central Asia: implications for control of high blood pressure. Eur Heart J. 2011 Jun;32(11):1424–31.

WHO publishes definitive atlas on global heart disease and stroke epidemic. Indian J Med Sci. 2004 Sep;58(9):405–6.

Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P. Stroke. Lancet. 2003 Oct 11;362(9391):1211–24.

Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, et al. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004 Feb;35(2):426–31.

Connor MD, Walker R, Modi G, Warlow CP. Burden of stroke in black populations in sub-Saharan Africa. Lancet Neurol. 2007 Mar;6(3):269–78.

Mapoure NY, Tchaleu Nguenkam CB, Mbatchou Ngahane HB, Dzudie A, Coulibaly A, Mounjouopou NG, et al. Predictors of in-hospital mortality for stroke in Douala, Cameroon. Stroke Res Treat. 2014;2014:681209.

Obiako O, Ogunniyi A, Oparah S. Prognosis and outcome of acute stroke in the University College Hospital Ibadan, Nigeria. Niger J Clin Pract. 2011;14(3):359.

Komolafe MA, Ogunlade O, Komolafe EO. Stroke mortality in a teaching hospital in South Western Nigeria. Trop Doct. 2007 Jul;37(3):186–8.

Beyiha Q, Minkande E, Binam F, Sosso MA. Aspects épidémiologiques et facteurs de gravité des accidents vasculaires cérébraux au Cameroun. J Maghréb Anesth-Réanimation Médecine Urgence. 2008;15(66):293–7.

Cochran WG. Some Methods for Strengthening the Common χ2 Tests. Biometrics. 1954;10(4):417–51.

Armitage P. Tests for Linear Trends in Proportions and Frequencies. Biometrics. 1955;11(3):375–86.

Touré K, Diagne SN, Seck BL, others. Predictors of stroke mortality at the department of neurology, fann university teaching hospital, Dakar-Senegal. Afr J Neurol Sci. 2010;29(2):325–34.

Walker RW, Rolfe M, Kelly PJ, George MO, James OFW. Mortality and recovery after stroke in the Gambia. Stroke. 2003 Jul;34(7):1604–9.

Nkoke C, Lekoubou A, Balti E, Kengne AP. Stroke mortality and its determinants in a resource-limited setting: A prospective cohort study in Yaounde, Cameroon. J Neurol Sci. 2015 Nov 15;358(1-2):113–7.

Saposnik G, Jeerakathil T, Selchen D, Baibergenova A, Hachinski V, Kapral MK, et al. Socioeconomic status, hospital volume, and stroke fatality in Canada. Stroke. 2008 Dec;39(12):3360–6.

Ogbu UC, Westert GP, Slobbe LCJ, Stronks K, Arah OA. A multifaceted look at time of admission and its impact on case-fatality among a cohort of ischaemic stroke patients. J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):8–13.

Andersen KK, Andersen ZJ, Olsen TS. Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke. Stroke. 2011 Oct;42(10):2806–12.

Bhalla A, Gupta OP, Gupta SB. Predicting mortality in stroke. Neurol India. 2002 Sep;50(3):279–81.

Yilmaz C, Kabatas S, Gulsen S, Cansever T, Gurkanlar D, Caner H, et al. Spontaneous supratentorial intracerebral hemorrhage: Does surgery benefit comatose patients? Ann Indian Acad Neurol. 2010 Jul;13(3):184–7.

Lekoubou A, Nkoke C, Dzudie A, Kengne AP. Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: A fourteen year trend study from 1999 to 2012. J Neurol Sci. 2015 Mar 15;350(1–2):24–32.

Hårdemark HG, Wesslén N, Persson L. Influence of clinical factors, CT findings and early management on outcome in supratentorial intracerebral hemorrhage. Cerebrovasc Dis. 1999 Feb;9(1):10–21.

Kim J, Song T-J, Park JH, Lee HS, Nam CM, Nam HS, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012 Jun;222(2):464–7.

Zia E, Engström G, Svensson PJ, Norrving B, Pessah-Rasmussen H. Three-year survival and stroke recurrence rates in patients with primary intracerebral hemorrhage. Stroke. 2009 Nov;40(11):3567–73.

Ekeh B, Ogunniyi A, Isamade E, Ekrikpo U. Stroke mortality and its predictors in a Nigerian teaching hospital. Afr Health Sci. 2015 Mar;15(1):74–81.

Desalu OO, Wahab KW, Fawale B, Olarenwaju TO, Busari OA, Adekoya AO, et al. A review of stroke admissions at a tertiary hospital in rural Southwestern Nigeria. Ann Afr Med. 2011 Jun;10(2):80–5.

Garbusinski JM, van der Sande MAB, Bartholome EJ, Dramaix M, Gaye A, Coleman R, et al. Stroke presentation and outcome in developing countries: a prospective study in the Gambia. Stroke. 2005 Jul;36(7):1388–93.

Sène Diouf F, Basse AM, Ndao AK, Ndiaye M, Touré K, Thiam A, et al. Pronostic fonctionnel des accidents vasculaires cérébraux dans les pays en voie de développement : Sénégal. Ann Réadapt Médecine Phys. 2006 Apr;49(3):100–4.

Mortalité par Accident Vasculaire Cérébral et ses déterminants dans un Hôpital de référence de Douala (Cameroun)

Article Sidebar

Main Article Content

Abstract

Article Details

Kuate-Tegueu Callixte, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1

Mapoure-Njankouo Yacouba, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala

Doumbe Jacques, Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala

Djientcheu Vincent de Paul, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, Cameroun

References

References

Similar Articles