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RÉSUMÉ

Background. The association between HbA1c and cardiovascular disease (CVD) risk is well established. Aim. to investigate the association between HbA1c and selected cardiometabolic markers in diabetic patients in the Adamaoua region. Materials and Methods. A cross sectional study was conducted at the Hypertension and Diabetes units of the Ngaoundere Regional and Protestant Hospitals from June 2015 to February 2016 in Ngaoundere, Adamawa Region, Cameroon. Recruited participants provided a written consent and subsequently filled a questionnaire on sociodemographic data. Blood pressure (BP) and anthropometric parameters were measured. Venous blood was collected for fasting blood glucose (FBG), lipid profile, glycated hemoglobin (HbA1c) and uric acid measurements. Data were analysed using SPSS version 20.0, with statistical significance considered at p < 0.05. Results. A total of 191 diabetic participants were enrolled. The majority (78.7%) of them recorded a poor glycaemic control (HbA1c > 7.9%). HbA1c levels varied inversely with waist-to-hip ratio and directly with serum uric acid. Apart from uric acid, waist-to-hip ratio, and high density lipoprotein cholesterol (HDLc), the means of all other study variables were significantly associated with increasing HbA1c category. Conclusion. Glycated hemoglobin is a potential predictor of dyslipidemia, overweight, and hypertension in both diabetic and non-diabetic persons in our setting.

 

ABSTRACT

Contexte. Le lien entre la fraction c de l’hémoglobine glycosylée (HbA1c) et le risque cardiovasculaire est bien établi. Objectif : analyser la relation entre l’ HbA1c et quelques marqueurs cardiométaboliques dans un groupe de sujets diabétiques de la région de l’Adamaoua. Matériels et méthodes. Nous avons mené une étude transversale dans les unités de prise en charge du diabète et de l’hypertension artérielle des hôpitaux Régional et Protestant de Ngaoundéré au Cameroun, de Juin 2015 à Février 2016. Après un consentement éclairé des participants, les données sociodémographiques ont été collectées ; la pression artérielle et les données anthropométriques ont été mesurées. Un échantillon de sang veineux a été prélevé chez les participants à jeun pour le dosage du glucose, des lipides, de l’HbA1c et de l’acide urique. Les données ont été analysées à l’aide du logiciel SPSS version 20.0 et les valeurs de p < 0,05 étaient considérées comme significatives. Résultats : Un total de 191 personnes diabétiques ont été recrutées. La majorité (78,7%) de ces participants avaient un mauvais controle glycémique (HbA1c > 7,9%). Il y avait une corrélation négative statistiquement significative entre le taux d’HbA1c et le rapport tour de hanche/tour de taille et une corrélation positive significative entre ce même paramètre et le taux sérique d’acide urique. A l’exception de l’acide urique, du HDLc et du rapport tour de hanche /tour de taille, tous les autres paramètres étudiés étaient significativement associés au taux HbA1c. Conclusion : le taux d’hémoglobine glycosylée est un potentiel facteur prédictif des dyslipidémies, du surpoids et de l’hypertension artérielle dans notre contexte, autant chez les diabétiques que les autres.

Keywords

Glycated Hemoglobin Serum Lipids Anthropometric Measures Diabetes Uric acid.

Article Details

How to Cite
Ngoufack, T. J. O., Mbouemboue, O. P., Touko, A. M., Haman, H. S., Amanissa, P. D., Mbo Amvene, J., & Tamanji, M. T. (2018). Relationship between HbA1c level and Cardiometabolic Markers in Diabetic patients from Ngaoundere. HEALTH SCIENCES AND DISEASE, 19(3). https://doi.org/10.5281/hsd.v19i3.1084
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