Growth and Puberty in a Group a Cameroonian Children with Type I Diabetes: a Cross Sectional Study

Suzanne Sap, Louis De Djob, Mesmin Dehayem, Ritha Mbono, Jobert Richie N. Nansseu, Adele Bodieu, Jean Claude Mbanya, Paul Olivier Koki

Abstract



ABSTRACT
Aim: Describe growth and puberty of Cameroonian children living with diabetes Patients and methods: we carried out a cross sectional study based on data provided by the national registry of children living with diabetes. We analysed Height, weight¸ body mass index derived in standard deviation for age and sex, tanner stage to evaluate puberty and haemoglobin A1c to evaluate metabolic control. Linear regression was used to analyzed correlation between variables. Results. We included 151 patients meeting inclusion criteria. Median height was -0.5 SDS (IQR – 5.5 to + 3 SDS), -0.3 and -1 for girls and boys respectively (p=0.24) in the studied population. We found growth retardation in 11.25% of them equally boys and girls. A positive correlation was found between haemoglobin A1c and growth retardation (r² 0.57). Overweight and obesity was found in 13% of patients mostly in girls. Median age of menarche was 13.23 years. Conclusion: We concluded that on patient on ten is affected with growth retardation and the latter is correlated with metabolic control. Some can be explained by pubertal delay but other aetiologies have to be ruled out.
RÉSUMÉ
Objectif: Décrire la croissance et la puberté des enfants camerounais vivant avec le diabète. Patients et méthodes: nous avons mené une étude transversale basée sur des données fournies par le registre national des enfants atteints de diabète. Nous avons analysé la taille, le poids index de l'indice de masse corporelle dérivé en déviation standard pour l'âge et le sexe, le stade Tanner pour évaluer la puberté et l'hémoglobine A1c pour évaluer le contrôle métabolique. La régression linéaire a été utilisée pour analyser la corrélation entre les variables. Résultats. Nous avons inclus 151 patients répondant aux critères d'inclusion. La taille médiane était de -0,5 SDS (IQR - 5,5 à + 3 SDS), -0,3 et -1 respectivement pour les filles et les garçons (p = 0,24) dans la population étudiée. Nous avons trouvé un retard de croissance chez 11,25% d’entre eux, filles et garçons. Une corrélation positive a été trouvée entre l'hémoglobine A1c et le retard de croissance (r² 0,57). La surcharge pondérale et l'obésité ont été retrouvés chez 13% des patients, principalement chez les filles. L'âge médian des premières règles était de 13,23 ans. Conclusion: Nous avons conclu que le retard de croissance était affecté chez un patient sur dix et que ce dernier était en corrélation avec le contrôle métabolique. Certains peuvent s'expliquer par un retard pubertaire mais d'autres étiologies doivent être exclues.


Keywords


type I diabetes, puberty, growth,

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References


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