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Abstract
Dans cet article, les auteurs font une revue des connaissances actuelles sur le rôle des intégrines dans le comportement biologique des cancers, de sa genèse, sa progression à sa métastatisation. Au moment où plusieurs approches sont étudiées pour le traitement de cette pathologie, la recherche du rôle des intégrines, en même temps qu’elle renforce le fait de la complexité biologique de la cellule cancéreuse, ouvre en même temps la voie des perspectives de thérapie médicale supplémentaire.
In this article, the authors review the role of integrins in the biologic behaviour of cancer, from its genesis to its progression and metastasis. Within the context of the many approaches that exist for the treatment of the disease, this review highlights the biologic complexity of the malignant cells and points the way to additional therapies.
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References
- - Mbakop A, Essame Oyono JL, Ngbankako MC, Abondo A. Current epidemiology of cancers in Cameroon (Central Africa). Bull Cancer 79 (11): 1101-4, 1992.
- - Pierres A, Benoliel AM, Bongrand P. Les molécules d'adhésion en cancérologie. La Revue de Médecine Interne 20(12) : 1099-1113, 1999
- - Misejewski GJ. Role of integrins in Cancer: survey of expression patterns. Proc Sco Exp Biol Med 222(2): 124 – 138, 1999.
- - Hood JD, Cheresh DA. Role of integrin in cell invasion and migration. Nature Reviews Cancer 2: 91 – 100, 2002.
- - Hynes RC. Integrines : a family of cell surface receptors. Cell 48: 549-54,1987.
- - Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEBJ 4:2868-80, 1990.
- - Labat RJ. Integrines. Path Biol 40 : 883 – 888,1992.
- - Rouoslanti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrines. Science 238: 491-97, 1987.
- - Hynes RO. Integrines : versatility, modulation, and signalling in cell adhesion. Cell 69: 11-25, 1992.
- - Nicolson GL. Growth Mechanism and Cancer Progression. Hosp. Pract 28: 43-53, 1990.
- - Plantefaber LC, Hynes RO. Changes in integrins receptor on oncogenical transformed cells. Cell 56 : 281-90,1989.
- - Giancotti FG, Ruoslahti E. Elevated levels of the 5 β1 fibrorectin receptor suppress the transformed phenotype of Chinese hamaster ovary cell. Cell 50 : 641 –46, 1990.
- - Mortarini R, Gismondi A, Santoni A, Parmiani G, Anichi A. Role of the 5 β1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibrorectin. Cancer. Res 52: 4499 – 506, 1992.
- - Ching-Shwon L, Ken Zhang , Kramer R. 6 – integrin is up-regulated in sleps in creme accompanying neoplasic transformation and tumorigenesis conversion of human fibroblasts. Cancer res 53: 2950-2953, 1993.
- - Topley P, Horwitz R, Bucc C, Rohrschneider L. Integrin isolated from Roos sarcoma virus – transformed chicken embryo fibroblast. Oncogene 4: 325-330, 1989.
- - Dedhar S. Saulnier R. Alteration in integrin receptor expression on chemically transformed human cells : specific enchancement of laminin and collagen receptor complexes. J Cell Biol 110: 481- 489, 1990.
- - Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibrorectin receptor induces collagenase and stromyelin gene expression. J Cell Biol 109 : 877-889, 1989.
- - Aznavoorian S ; Murphy AN, Steller – Stevenson WG, Lance AL. Molecular aspects of tumor cell invasion and metastasis. Cancer 71: 1368 -1378, 1993.
- - Wang BS, McLouglin GA, Richie JP, Mannick JA. Correlation of the production of plasminogen activator with tumor metastasis in β16, mouse melanoma cell lines. Cancer Res 40 : 288-292,1980.
- - Liotta LA, Trygvason K, Garbisa S, Hart I, Foltz CM, Shafie S Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284 : 67-68, 1980.
- - Akiyama SK, Yamada SS, Chen WT, Yamada KM. Analysis of receptor function with monoclonal anti-bodies : roles in cell adhesion, migration, matrix assembly and cytoskeletal organisation. J cell biol 1989 ;109 : 863-875.1989.
- - Dedhar S, Saulnier R. Alterations in integrins receptor expression on chemically transformed and collagen receptor complexes. J Cell biol 110 : 481-489,1990.
- - Springer TA. Adhesion receptors of the immune system. Nature 346 : 425-34,1990.
- - Roossien FF, De Ruk D, Bikker A, Roos E. Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated in the deficient mutants. J cell. Biol 108: 1979-1985,1989.
- - Honn KV, Nelson KK, Renaud C, Bazaz R, Diglio CA, Timar J. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandin 44: 413-429, 1992.
- - Wojtukiewicz MZ, Tang DG, Nelson KK, Walz DA, Diglio CA, Honn KV. Thrombin enchances tumor cell adhesive and metastatic properties via increased 11 β3 expression on the cell surface . Thromb Res 68: 233-245,1992.
- - Goncalves MH, Veiga SS, Chammas R, Potocnjak P. Tumor metastasis modulation by thyroxine. J Cell 111 : 145-52, 1990.
- - Fokas E, Engenhart-Cabillic R, Daniilidis K, Rose F, An H-X. Metastasis : the seed and soil theory gains identity. Cancer Metastasis Review 26 (3-4): 705-715, 2007.
- - Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibrorectin inhibits experimental metastasis of murine melanoma cells. Science 233 : 467-469, 1986.
- - Chan BMC, Matsoora N, Takada Y, Zetter BR. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science 251 : 1600-1602, 1991.
- - Demeure MJ. Damsky CH, Glaman F, Goretzki PE, Wong MG, Orlo HC. Invasion by cultured human follicular thyroid cancer correlates with increased β1 integrins and production of proteases. World J Surg 16:770-776, 1992.
- - Honn VK, Chen QY, Timar J, Onoda JM, Hatfield JS, Fligiel EGS, Bruce WS, Diglio CA, Grossi IM, Nelson KK, Taylor JD. 11 b β3 integrin expression and function in subpopulation of murine tumors. Exp Cell Res 201 : 23-32, 1992.
- - Vink J, Thomas L, Takafomi E, Bruijn JA, Mihm MC, Gattoni-Celli S, Byers AR. Role of beta-1 integrines in organ specific adhesion of melanoma cells. Lab Invest 68: 192-203, 1993.
- - Eble JA, Haier J. Integrins in cancer treatment. Curr Cancer Drug Targets 6 : 89-105,2006.
References
- Mbakop A, Essame Oyono JL, Ngbankako MC, Abondo A. Current epidemiology of cancers in Cameroon (Central Africa). Bull Cancer 79 (11): 1101-4, 1992.
- Pierres A, Benoliel AM, Bongrand P. Les molécules d'adhésion en cancérologie. La Revue de Médecine Interne 20(12) : 1099-1113, 1999
- Misejewski GJ. Role of integrins in Cancer: survey of expression patterns. Proc Sco Exp Biol Med 222(2): 124 – 138, 1999.
- Hood JD, Cheresh DA. Role of integrin in cell invasion and migration. Nature Reviews Cancer 2: 91 – 100, 2002.
- Hynes RC. Integrines : a family of cell surface receptors. Cell 48: 549-54,1987.
- Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEBJ 4:2868-80, 1990.
- Labat RJ. Integrines. Path Biol 40 : 883 – 888,1992.
- Rouoslanti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrines. Science 238: 491-97, 1987.
- Hynes RO. Integrines : versatility, modulation, and signalling in cell adhesion. Cell 69: 11-25, 1992.
- Nicolson GL. Growth Mechanism and Cancer Progression. Hosp. Pract 28: 43-53, 1990.
- Plantefaber LC, Hynes RO. Changes in integrins receptor on oncogenical transformed cells. Cell 56 : 281-90,1989.
- Giancotti FG, Ruoslahti E. Elevated levels of the 5 β1 fibrorectin receptor suppress the transformed phenotype of Chinese hamaster ovary cell. Cell 50 : 641 –46, 1990.
- Mortarini R, Gismondi A, Santoni A, Parmiani G, Anichi A. Role of the 5 β1 integrin receptor in the proliferative response of quiescent human melanoma cells to fibrorectin. Cancer. Res 52: 4499 – 506, 1992.
- Ching-Shwon L, Ken Zhang , Kramer R. 6 – integrin is up-regulated in sleps in creme accompanying neoplasic transformation and tumorigenesis conversion of human fibroblasts. Cancer res 53: 2950-2953, 1993.
- Topley P, Horwitz R, Bucc C, Rohrschneider L. Integrin isolated from Roos sarcoma virus – transformed chicken embryo fibroblast. Oncogene 4: 325-330, 1989.
- Dedhar S. Saulnier R. Alteration in integrin receptor expression on chemically transformed human cells : specific enchancement of laminin and collagen receptor complexes. J Cell Biol 110: 481- 489, 1990.
- Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibrorectin receptor induces collagenase and stromyelin gene expression. J Cell Biol 109 : 877-889, 1989.
- Aznavoorian S ; Murphy AN, Steller – Stevenson WG, Lance AL. Molecular aspects of tumor cell invasion and metastasis. Cancer 71: 1368 -1378, 1993.
- Wang BS, McLouglin GA, Richie JP, Mannick JA. Correlation of the production of plasminogen activator with tumor metastasis in β16, mouse melanoma cell lines. Cancer Res 40 : 288-292,1980.
- Liotta LA, Trygvason K, Garbisa S, Hart I, Foltz CM, Shafie S Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284 : 67-68, 1980.
- Akiyama SK, Yamada SS, Chen WT, Yamada KM. Analysis of receptor function with monoclonal anti-bodies : roles in cell adhesion, migration, matrix assembly and cytoskeletal organisation. J cell biol 1989 ;109 : 863-875.1989.
- Dedhar S, Saulnier R. Alterations in integrins receptor expression on chemically transformed and collagen receptor complexes. J Cell biol 110 : 481-489,1990.
- Springer TA. Adhesion receptors of the immune system. Nature 346 : 425-34,1990.
- Roossien FF, De Ruk D, Bikker A, Roos E. Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated in the deficient mutants. J cell. Biol 108: 1979-1985,1989.
- Honn KV, Nelson KK, Renaud C, Bazaz R, Diglio CA, Timar J. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandin 44: 413-429, 1992.
- Wojtukiewicz MZ, Tang DG, Nelson KK, Walz DA, Diglio CA, Honn KV. Thrombin enchances tumor cell adhesive and metastatic properties via increased 11 β3 expression on the cell surface . Thromb Res 68: 233-245,1992.
- Goncalves MH, Veiga SS, Chammas R, Potocnjak P. Tumor metastasis modulation by thyroxine. J Cell 111 : 145-52, 1990.
- Fokas E, Engenhart-Cabillic R, Daniilidis K, Rose F, An H-X. Metastasis : the seed and soil theory gains identity. Cancer Metastasis Review 26 (3-4): 705-715, 2007.
- Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibrorectin inhibits experimental metastasis of murine melanoma cells. Science 233 : 467-469, 1986.
- Chan BMC, Matsoora N, Takada Y, Zetter BR. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science 251 : 1600-1602, 1991.
- Demeure MJ. Damsky CH, Glaman F, Goretzki PE, Wong MG, Orlo HC. Invasion by cultured human follicular thyroid cancer correlates with increased β1 integrins and production of proteases. World J Surg 16:770-776, 1992.
- Honn VK, Chen QY, Timar J, Onoda JM, Hatfield JS, Fligiel EGS, Bruce WS, Diglio CA, Grossi IM, Nelson KK, Taylor JD. 11 b β3 integrin expression and function in subpopulation of murine tumors. Exp Cell Res 201 : 23-32, 1992.
- Vink J, Thomas L, Takafomi E, Bruijn JA, Mihm MC, Gattoni-Celli S, Byers AR. Role of beta-1 integrines in organ specific adhesion of melanoma cells. Lab Invest 68: 192-203, 1993.
- Eble JA, Haier J. Integrins in cancer treatment. Curr Cancer Drug Targets 6 : 89-105,2006.