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Abstract
RÉSUMÉ
L’incidence des tumeurs cérébrales chez l’enfant est faible dans les pays pauvres par rapport aux pays industrialisés, probablement parce qu’un grand nombre d’enfants décèdent sans diagnostic précis du fait des ressources financières limitées d’une part et de l’absence d’accès aux techniques modernes de diagnostic d’autres part. Nous rapportons l’observation d’un garçon de 12 ans portant un drain ventriculopéritonéal placé en urgence devant une hypertension intracrânienne tumorale. La localisation pinéale et les caractères de la tumeur en IRM avaient fait suspecter une tumeur germinale. L’élévation de l’alphafœtoprotéine a confirmé le diagnostic de tumeur germinale sécrétante de la glande pinéale. La chimiothérapie a fait disparaître tous les symptômes.
ABSTRACT
The incidence of pediatric cerebral tumors is low in developing countries compared to industrialized countries; probably because many children die prior to diagnosis either because of limited financial resources or because of the limited access to modern technologies of diagnosis. We report the case of a 12 year old boy with an emergency placement of ventriculoperitoneal shunt because of tumoral intracranial hypertension. Pineal localization and MRI features lead to the diagnosis of a germinal tumor. The elevation of the alpha fetoprotein tumoral marker confirmed the diagnosis of secreting germ cell tumor of the pineal region. Chemotherapy alleviated all the symptoms.
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References
- Lee D, Suh YL. (2010) Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute.Virchows Arch. Sep; 457:347-57.
- Hirato J, Nakazaro Y. (2001) Pathology of pineal region tumors. J Neurooncol. Sep;54: 239-49
- Gaillard F, Jones J. (2010) Masses of the pineal region: clinical presentation and radiographic features. Postgrad Med J. Oct; 90(2020):597-607.
- Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T. (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 1997; 86: 446 - 455.
- Radovanovic I, Dizdarevic K, de Tribolet N, Masic T, Muminagic S. (2009). Pineal region tumors—neurosurgical review. Med Arch;63(3):171-3.
- Souweidane M, Krieger M, Weiner H, and Finlay J.(2010) Surgical management of primary central nervous system germ cell tumors. J Neurosurg pediatrics ; 6: 125 - 130
- Lakhar F, Hemama M, Laghmari M, Gana R, Maaqili R, Bellakhdar F.(2008) Double localisation d’un germinome cérébral à propos d’un cas. Journal of Neuroradiology ; 35: 177 – 180.
- Hmed S, Shalet S, Price D, and Pearson D.(2011) Human chorionic gonadotrophin secreting pineal germinoma and precocious puberty. Downloaded from adc.bmj.com on June 6, 2011.
- Brandes AA, Pasetto LM, Monfardini S.(2000) The treatment of cranial germ cell tumors. Cancer Treat Rev. Aug; 26: 233-42.
- Göbel U, Schneider D, Calaminus G, Haas R, Schmidt P & Harms D on behalf of the GPOH MAKEI and the MAHO study groups.(2000) Germ-cell tumors in childhood and adolescence. Annals of Oncology ; 11: 263 - 271.
- Kuo H, Sheen J,Wu K, Wei H, Hsiao C.(2006) Precocious puberty due to human chorionic gonadotropin-secreting pineal tumor. Chang Gung Med J vol.29 No.2
- Ginsberg S, Kirshner J, Reich S, Panasci L, Finkelstein T, Frandrich S, Fitzpatrick A, Shechtman L, Comis R.(1981) Systemic chemotherapy for a primary germ cell tumor of the brain –a pharmacokinetic study. Cancer Treat Rep ; 65: 477 - 483
- Kobayashi T, Yoshida J, Ishimaya J, Noda S, Kito A, Kida Y.(1989) Combination chemotherapy with Cisplatine and Etoposide for malignant intracranial germ cell tumors: an experimental and clinical study. J Neurosurg; 70: 676 – 681.
- Requiro CA.(2003) Treatment of intracranial germ cell tumours and other tumours of the pineal region.Neurocirugia (astur). Apr;14(2):127-39.
- Nathalie Chivoret. Les tumeurs pinéales de l’enfant : à propos d’une série de 101 patients et revue de la littérature. Médecine humaine et pathologie. 2013. dumas-00933489
References
Lee D, Suh YL. (2010) Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute.Virchows Arch. Sep; 457:347-57.
Hirato J, Nakazaro Y. (2001) Pathology of pineal region tumors. J Neurooncol. Sep;54: 239-49
Gaillard F, Jones J. (2010) Masses of the pineal region: clinical presentation and radiographic features. Postgrad Med J. Oct; 90(2020):597-607.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T. (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 1997; 86: 446 - 455.
Radovanovic I, Dizdarevic K, de Tribolet N, Masic T, Muminagic S. (2009). Pineal region tumors—neurosurgical review. Med Arch;63(3):171-3.
Souweidane M, Krieger M, Weiner H, and Finlay J.(2010) Surgical management of primary central nervous system germ cell tumors. J Neurosurg pediatrics ; 6: 125 - 130
Lakhar F, Hemama M, Laghmari M, Gana R, Maaqili R, Bellakhdar F.(2008) Double localisation d’un germinome cérébral à propos d’un cas. Journal of Neuroradiology ; 35: 177 – 180.
Hmed S, Shalet S, Price D, and Pearson D.(2011) Human chorionic gonadotrophin secreting pineal germinoma and precocious puberty. Downloaded from adc.bmj.com on June 6, 2011.
Brandes AA, Pasetto LM, Monfardini S.(2000) The treatment of cranial germ cell tumors. Cancer Treat Rev. Aug; 26: 233-42.
Göbel U, Schneider D, Calaminus G, Haas R, Schmidt P & Harms D on behalf of the GPOH MAKEI and the MAHO study groups.(2000) Germ-cell tumors in childhood and adolescence. Annals of Oncology ; 11: 263 - 271.
Kuo H, Sheen J,Wu K, Wei H, Hsiao C.(2006) Precocious puberty due to human chorionic gonadotropin-secreting pineal tumor. Chang Gung Med J vol.29 No.2
Ginsberg S, Kirshner J, Reich S, Panasci L, Finkelstein T, Frandrich S, Fitzpatrick A, Shechtman L, Comis R.(1981) Systemic chemotherapy for a primary germ cell tumor of the brain –a pharmacokinetic study. Cancer Treat Rep ; 65: 477 - 483
Kobayashi T, Yoshida J, Ishimaya J, Noda S, Kito A, Kida Y.(1989) Combination chemotherapy with Cisplatine and Etoposide for malignant intracranial germ cell tumors: an experimental and clinical study. J Neurosurg; 70: 676 – 681.
Requiro CA.(2003) Treatment of intracranial germ cell tumours and other tumours of the pineal region.Neurocirugia (astur). Apr;14(2):127-39.
Nathalie Chivoret. Les tumeurs pinéales de l’enfant : à propos d’une série de 101 patients et revue de la littérature. Médecine humaine et pathologie. 2013. dumas-00933489