Main Article Content

Abstract

RÉSUMÉ
Le xanthogranulome juvénile (XGJ) est une pathologie rare. Bien qu’il puisse survenir à tout âge, il se développe préférentiellement chez le jeune enfant de sexe masculin. Son siège est ubiquitaire avec prédilection pour la peau. C’est essentiellement une pathologie bénigne mais qui peut entacher le pronostic vital en fonction de sa localisation. Son diagnostic de certitude est histologique couplé ou non à une analyse immunohistochimique. L’aspect histologique est identique quelle que soit la localisation. L’immunohistochimie montre une positivité diffuse des cellules au CD68. Nous présentons ici le premier cas de XGJ décrit au Cameroun, pour en relever les particularités diagnostiques.
ABSTRACT
Juvenile xanthogranuloma (JXG) is a rare pathology. Although it can occur at any age, it preferentially develops in young male children. JXG is ubiquitous but with predilection for the skin. It is essentially a benign pathology but can taint the vital prognosis depending on its location. Its diagnosis is made with histopathology coupled or not with immunohistochemical analysis. The histological aspect is identical regardless of the location. Immunohistochemistry shows diffuse cell positivity to CD68. We present here the first case of JXG described in Cameroon, to identify the diagnostic particuliarities.

Keywords

Xanthogranulome juvénile, Immunohistochimie, enfant camerounais

Article Details

How to Cite
Paul Jean Adrien Atangana, Coralie Reine Bertine Mendouga Menye, Grace Anita Nkoro Ombede, René Ghislain Essomba, Sidonie Ananga Noa, Alice Ndoumba, Jean Louis Essame Oyono, Zacharie Sando, & Emmanuel Armand Kouotou. (2022). Xanthogranulome Juvénile, Variante à Cellules Fusiformes chez un Enfant Camerounais: Apport de l’Immunohistochimie au Diagnostic. HEALTH SCIENCES AND DISEASE, 23(8). Retrieved from https://hsd-fmsb.org/index.php/hsd/article/view/3835

References

  1. first two decades of life: A clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. 2003 May 1;27(5):579–93.
  2. Vanotti S, Chiaverini C, Rostain G, Cardot-Leccia N, Lacour JP. Xanthogranulome juvénile éruptif localisé. Ann Dermatol Venereol. 2014;141(3):206–10.
  3. Chancellor JR, Gonzalez-Krellwitz LA, Pemberton JD. Rubbery nodule on the face of an infant. Cutis. 2019 Aug;104(2):92;97-98.
  4. Castilla EA, Ormsby A. Adult xanthogranuloma of the vulva: case report and review. Pathology. 2002 Feb;34(1):86–7.
  5. Gupta B, Yadav S, Khurana N, Sharma M. Juvenile Xanthogranuloma in Vulva of a 10-Year-Old Child. J Clin Diagn Res. 2016 Nov;10(11):ED21–2.
  6. Cirstoiu M, Mitrache LE, Popa M, Mehotin NC, Sajin M, Cirstoiu C. A Rare Case of Benign Xanthogranuloma Located on the Uterine Cervix - a Case Report. Maedica (Buchar). 2015 Jun;10(2):127–30.
  7. Flaitz C, Allen C, Neville B, Hicks J. Juvenile xanthogranuloma of the oral cavity in children: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Sep;94(3):345–52.
  8. Myeong H-S, Koh EJ, Cheon J-E, Park S-H, Kim S-K. Intracranial juvenile xanthogranuloma in an infant. Childs Nerv Syst. 2021;37(10):3265–9.
  9. Caputo R, Grimalt R, Gelmetti C, Cottoni F. Unusual aspects of juvenile xanthogranuloma. J Am Acad Dermatol. 1993 Nov;29(5 Pt 2):868–70.
  10. Consolaro A, Sant’Ana E, Lawall MA, Consolaro MFMO, Bacchi CE. Gingival juvenile xanthogranuloma in an adult patient: case report with immunohistochemical analysis and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Feb;107(2):246–52.
  11. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: A clinicopathologic study of 129 patients from the Kiel Pediatric Tumor Registry. Am J Surg Pathol. 2005 Jan;29(1):21–8.