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RÉSUMÉ
Introduction. La tuberculose est une maladie chronique qui peut causer des dommages structurelles de l’organe atteint et ainsi êtreresponsable à long terme d’altérations anatomiques et fonctionnelle  avec pour conséquences chroniques. La réduction du volume expiratoire maximal seconde (VEMS) est un facteur prédictif indépendant de la mortalité en rapport avec les maladies respiratoires. Objectifs. Déterminer la prévalencede l’altération de la fonction pulmonaire chez les patients ayant un antécédent de tuberculose pulmonaire(TBP). Méthodes. Il s'agissait d'une étude transversale incluant tous les participants âgés de 19 ans et plus avec des antécédents de TBP dans cinq villes du Cameroun : Yaoundé, Douala,Bandjoun,Garoua et Figuil entre 2014 et 2018. Nous avons analysé les caractéristiques sociodémographiques, cliniques et spirométriques des participants. Une altération de la fonction pulmonaire était définie comme un VEMS inférieur à la limite inférieure de la normale (LIN). La prévalence de l’altération de la fonction pulmonaire a été calculée comme une proportion des participants présentant le trouble ventilatoire avec un intervalle de confiance de 95%. Résultats. Des 137 participants définitivement inclus dans notre étude, 51,1% (70 sujets) étaient des hommes et 48,9% (67 sujets) étaient des femmes avec un âge moyen (± écart type) 47 ± 13.9 annéesUne altération de la fonction pulmonaire a été identifiée chez 15 des 137 participants donnant ainsi une prévalence (Intervalle de confiance a 95%) l’AFP de (10,9 %6,2% - 17,4% ). Cette AFP était modérée dans 80% des cas. Conclusion. La prévalence de l’altération de la fonction pulmonaire dans notre population d’étude était de 10.9%. La majorité présentait une altération de la fonction pulmonaire modérée.
ABSTRACT
Introduction. Tuberculosis is a chronic disease which can cause structural damage to the affected organs, thereby resulting in long term anatomical and functional abnormalities with chronic consequences. Reduced FEV1 has been shown to be an independent predictor of respiratory disease-related mortality. Objective. To investigate the prevalenceof altered pulmonary function in subjects with past history of pulmonary tuberculosis (PTB). Methods. It was a cross sectional study including all participants aged nineteen years and above with past history of PTB from five towns in Cameroon: Yaounde, Douala, Bandjoun, Garoua and Figuil between 2014 and 2018. We analysed socio-demographic, clinical and spirometric characteristics of participants. An altered pulmonary function (APF) was defined as FEV1 below the lower limit of normal. The prevalence of APF was calculated as a proportion of those with the outcome. Results. Of the 137 subjects finally included in our study 51.1% (70 subjects) were men and 48.9% (67 subjects) were women, with a mean age (±standard deviation) of 47 ± 13.9 years. Pulmonary impairment was identified in 15 of the 137 participants giving a prevalence of pulmonary impairment (95% Confidence interval) of 10.9% 6,2% - 17,4%.This pulmonary function impairment was moderate in 80% of the cases. Conclusion. The prevalence of an APF in our population of study was 10.9%.The majority of those with APF had moderate pulmonary function impairment.

Keywords

Altération fonction pulmonaire ; tuberculose pulmonaire ; Cameroun.

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NgahKomo Marie Elisabeth, NgadiMbango Patience, Amadou Dodo Balkissou, Massongo Massongo, Nsounfon Abdou, Nsounfon Abdou, Poka - Mayap Virginie, Ekono Bitchong Claire, & Pefura – Yone Eric Walter. (2023). Prevalence of Altered Pulmonary Function in Subjects with Past History of Pulmonary Tuberculosis . HEALTH SCIENCES AND DISEASE, 24(2 Suppl 1). https://doi.org/10.5281/hsd.v24i2 Suppl 1.4265
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