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Abstract
ABSTRACT
Introduction. Intrauterine foetal death (IUFD); defined as foetal demise occurring after 22 completed weeks of gestation or with foetus weighing ≥500g, is of great concern in our healthcare delivery system. Understanding the factors associated with IUFD is imperative for the elaboration of effective prevention strategies. This study aimed to investigate the factors associated with IUFD in two hospitals in Yaoundé. Methods. We conducted a retrospective case-control study at the central hospital and Efoulan district hospital in Yaoundé; two hospitals known to have a high turnover of pregnant cases. We reviewed the medical records of women who delivered in these institutions from March 2021 to March 2023. Cases included files of women who had a confirmed diagnosis of IUFD from 22 completed weeks of gestation and before the onset of labour. Controls consisted of files of women with live births in the same hospitals during the same period, matched against maternal age and parity. A total of 155 cases and 155 controls were included in the analysis. Results. Our study identified several significant risk factors associated with IUFD. They include being single, housewife as occupation, a previous history of IUFD, having less than four antenatal contacts, being ill during pregnancy, foetal abnormalities, and placental abnormalities. Conversely, a university-level of education, receiving antenatal care from an obstetrician/gynaecologist or resident in obstetrics and gynaecology, and others were protective factors. Conclusion. Poor antenatal care, being single, housewife, having lower level of education, having a history of previous IUFD, maternal illnesses during pregnancy, foetal abnormalities, and placental abnormalities have higher odds of IUFD.
RÉSUMÉ
Introduction. La mort fœtale in utéro (MFIU) est une grande préoccupation dans notre contexte. Comprendre les facteurs y associés est impératif pour l'élaboration de stratégies de prévention. Cette étude visait à étudier les facteurs associés à la MFIU. Méthodes. Nous avons mené une étude rétrospective type cas-témoins à l'hôpital central et à l'hôpital de district d'Efoulan à Yaoundé, deux hôpitaux très fréquentés. Nous avons étudié les dossiers médicaux des femmes ayant accouché dans ces établissements de mars 2021 à mars 2023. Les cas comprenaient des dossiers de femmes qui avaient un diagnostic confirmé de MFIU à partir de 22 semaines révolues de grossesse et avant le début du travail. Les contrôles étaient des dossiers de femmes ayant eu des naissances vivantes dans ces hôpitaux durant la même période, appariées selon l'âge et la parité maternels. Au total, 155 cas et 155 témoins ont été inclus. Résultats. Notre étude a identifié comme facteurs de risque associés à la MFIU le fait d'être célibataire, une femme au foyer comme profession, l’antécédents de MFIU, avoir moins de quatre contacts prénatals, être malade pendant la grossesse, et des anomalies fœtales et placentaires. Par contre, un niveau d’éducation universitaire, avoir comme prestataire de soins prénatals un spécialiste ou résident en obstétrique-gynécologie, entre autres, étaient des facteurs protecteurs. Conclusion. Les soins prénatals inadéquats, être mère célibataire ou femme au foyer, un niveau d'éducation bas, l’antécédents de MFIU, les maladies maternelles pendant la grossesse, des anomalies fœtales et placentaires augmentent le risque de MFIU.
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References
- Nkwabong E, Fomulu J, Ambassa J. Stillbirths at University Teaching Hospital, Yaounde, Cameroon. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2012 Jul 13; 119:87–8.
- MacDorman MF, Gregory ECW. Fetal and Perinatal Mortality: United States, 2013. Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat Syst. 2015 Jul 23;64(8):1–24.
- What is stillbirth? [Internet]. [cited 2022 Nov 4]. Available from: https://pmnch.who.int/resources/tools-and-toolkits/stillbirths-toolkit/kenya/what-is-stillbirth
- Metogo Ntsama JA, Tatsipie WL, Bayokolak A, Mboua VB, Mbianda C, Um EMN, et al. Pregnancy identity card of women with fetal death in utero: case-control study in a reference hospital in metropolitan Cameroon. Int J Reprod Contracept Obstet Gynecol. 2022 Feb 25;11(3):683.
- Pramana C, Purwiandari H, Lie J, Saint H, Alexander D, Rianto L. Intrauterine Fetal Death of 32 weeks gestation with Omphalocele: A Case Report. Int J Med Rev Case Rep. 2021 Jan 1;1.
- Hug L, You D, Blencowe H, Mishra A, Wang Z, Fix MJ, et al. Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment. Lancet Lond Engl. 2021 Aug 28;398(10302):772–85.
- Sinha K, Pandey S. Risk Factors in Patients with Intrauterine Fetal Death at Tertiary Referral Centre. J Nepalgunj Med Coll. 2019 Dec 31;17(2):14–6.
- Egbe TO, Ewane EN, Tendongfor N. Stillbirth rates and associated risk factors at the Buea and Limbe regional hospitals, Cameroon: a case-control study. BMC Pregnancy Childbirth. 2020 Feb 3;20(1):75.
- Worede DT, Dagnew GW. Determinants of stillbirth in Felege-Hiwot comprehensive specialized referral hospital, North-west, Ethiopia, 2019. BMC Res Notes. 2019 Dec;12(1):579.
- Momo RJT, Fouedjio JH, Fouelifack FY, Mbu RE. Risk factors of intrauterine fetal death: a case control study at the maternity of Yaoundé Central Hospital. Int J Reprod Contracept Obstet Gynecol. 2019 May 28;8(6):2149.
- Tolefac PN, Tamambang RF, Yeika E, Mbwagbaw LT, Egbe TO. Ten years analysis of stillbirth in a tertiary hospital in sub-Sahara Africa: a case control study. BMC Res Notes. 2017 Dec;10(1):447.
- Luguterah A, Sagary Nokoe K. Pre-Pregnancy Risk Factors for Intrauterine Fetal Mortality in Ghana. Am J Public Health Res. 2013 Jun 11;1(5):124–8.
- Odendaal H, Dukes KA, Elliott AJ, Willinger M, Sullivan LM, Tripp T, et al. Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth. JAMA Netw Open. 2021 Aug 23;4(8): e2121726.
- Dejong K, Olyaei A, Lo JO. Alcohol Use in Pregnancy. Clin Obstet Gynecol. 2019 Mar;62(1):142–55.
- Chuwa FS, Mwanamsangu AH, Brown BG, Msuya SE, Senkoro EE, Mnali OP, et al. Maternal and fetal risk factors for stillbirth in Northern Tanzania: A registry-based retrospective cohort study. Leone T, editor. PLOS ONE. 2017 Aug 15 ;12(8) : e0182250.
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- Kasso T, Alegbeleye JO, Jeremiah I. Determinants of Intrauterine Fetal Death among Unbooked Paturients at the University of Port Harcourt Teaching Hospital, Southern Nigeria. Arch Curr Res Int. 2020 May 12;34–40.
- Oguejiofor CB, Okafor CD, Eleje GU, Ikechebelu JI, Okafor CG, Ugboaja JO, et al. A Five-Year Review of Feto-Maternal Outcome of Antepartum Haemorrhage in a Tertiary Center. Int J Innov Res Med Sci. 2023 Mar;8(3):96–101.
- Kulkarni VG, Sunilkumar KB, Nagaraj TS, Uddin Z, Ahmed I, Hwang K, et al. Maternal and fetal vascular lesions of malperfusion in the placentas associated with fetal and neonatal death: results of a prospective observational study. Am J Obstet Gynecol. 2021 Dec 1;225(6): 660.e1-660.e12.
- Tidiani T, K S, B T, Bm S, A S, C S, et al. Hypertension Artérielle et Grossesse: Aspects Epidémio-cliniques et Complications à l’Hôpital Nianankoro Fomba de Ségou. Health Sci Dis [Internet]. 2021 Sep 4 [cited 2024 May 9];22(9). Available from: http://hsd-fmsb.org/index.php/hsd/article/view/2975
- Njoku CO, Emechebe CI, Eyong EM, Ukaga JT, Anachuna KC. Prevalence and risk factors for stillbirths in a tertiary hospital in Niger Delta area of Nigeria: a ten-year review. Int J Med Biomed Res. 2016 Oct 3;5(3):106–13.
- Mondal D, Galloway TS, Bailey TC, Mathews F. Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births. BMC Med. 2014 Dec;12(1):220.
- Lankoande M, Bonkoungou P, Ouandaogo S, Dayamba M, Ouedraogo A, Veyckmans F, et al. Incidence and outcome of severe ante-partum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso. BMC Emerg Med. 2017 May 31 ;17(1):17.
References
Nkwabong E, Fomulu J, Ambassa J. Stillbirths at University Teaching Hospital, Yaounde, Cameroon. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2012 Jul 13; 119:87–8.
MacDorman MF, Gregory ECW. Fetal and Perinatal Mortality: United States, 2013. Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat Syst. 2015 Jul 23;64(8):1–24.
What is stillbirth? [Internet]. [cited 2022 Nov 4]. Available from: https://pmnch.who.int/resources/tools-and-toolkits/stillbirths-toolkit/kenya/what-is-stillbirth
Metogo Ntsama JA, Tatsipie WL, Bayokolak A, Mboua VB, Mbianda C, Um EMN, et al. Pregnancy identity card of women with fetal death in utero: case-control study in a reference hospital in metropolitan Cameroon. Int J Reprod Contracept Obstet Gynecol. 2022 Feb 25;11(3):683.
Pramana C, Purwiandari H, Lie J, Saint H, Alexander D, Rianto L. Intrauterine Fetal Death of 32 weeks gestation with Omphalocele: A Case Report. Int J Med Rev Case Rep. 2021 Jan 1;1.
Hug L, You D, Blencowe H, Mishra A, Wang Z, Fix MJ, et al. Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment. Lancet Lond Engl. 2021 Aug 28;398(10302):772–85.
Sinha K, Pandey S. Risk Factors in Patients with Intrauterine Fetal Death at Tertiary Referral Centre. J Nepalgunj Med Coll. 2019 Dec 31;17(2):14–6.
Egbe TO, Ewane EN, Tendongfor N. Stillbirth rates and associated risk factors at the Buea and Limbe regional hospitals, Cameroon: a case-control study. BMC Pregnancy Childbirth. 2020 Feb 3;20(1):75.
Worede DT, Dagnew GW. Determinants of stillbirth in Felege-Hiwot comprehensive specialized referral hospital, North-west, Ethiopia, 2019. BMC Res Notes. 2019 Dec;12(1):579.
Momo RJT, Fouedjio JH, Fouelifack FY, Mbu RE. Risk factors of intrauterine fetal death: a case control study at the maternity of Yaoundé Central Hospital. Int J Reprod Contracept Obstet Gynecol. 2019 May 28;8(6):2149.
Tolefac PN, Tamambang RF, Yeika E, Mbwagbaw LT, Egbe TO. Ten years analysis of stillbirth in a tertiary hospital in sub-Sahara Africa: a case control study. BMC Res Notes. 2017 Dec;10(1):447.
Luguterah A, Sagary Nokoe K. Pre-Pregnancy Risk Factors for Intrauterine Fetal Mortality in Ghana. Am J Public Health Res. 2013 Jun 11;1(5):124–8.
Odendaal H, Dukes KA, Elliott AJ, Willinger M, Sullivan LM, Tripp T, et al. Association of Prenatal Exposure to Maternal Drinking and Smoking With the Risk of Stillbirth. JAMA Netw Open. 2021 Aug 23;4(8): e2121726.
Dejong K, Olyaei A, Lo JO. Alcohol Use in Pregnancy. Clin Obstet Gynecol. 2019 Mar;62(1):142–55.
Chuwa FS, Mwanamsangu AH, Brown BG, Msuya SE, Senkoro EE, Mnali OP, et al. Maternal and fetal risk factors for stillbirth in Northern Tanzania: A registry-based retrospective cohort study. Leone T, editor. PLOS ONE. 2017 Aug 15 ;12(8) : e0182250.
Bwana Kangulu I, Mwembo Tambwe A'Nkoy A, Kabamba Nzaji M, Mbayo Kazadi A, Kilolo Ngoy Umba E, Ngoy Lumbule J, et al. Intrauterine Fetal Death in the Third Trimester of Pregnancy in Kamina, DR Congo: Identification of High-Risk Mothers and Impact of the Periodicity of Antenatal Care. J Gynecol Obstet [Internet]. 2023 Apr 15 [cited 2024 May 9]; Available from: http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=255&doi=10.11648/j.jgo.20231102.13
Kasso T, Alegbeleye JO, Jeremiah I. Determinants of Intrauterine Fetal Death among Unbooked Paturients at the University of Port Harcourt Teaching Hospital, Southern Nigeria. Arch Curr Res Int. 2020 May 12;34–40.
Oguejiofor CB, Okafor CD, Eleje GU, Ikechebelu JI, Okafor CG, Ugboaja JO, et al. A Five-Year Review of Feto-Maternal Outcome of Antepartum Haemorrhage in a Tertiary Center. Int J Innov Res Med Sci. 2023 Mar;8(3):96–101.
Kulkarni VG, Sunilkumar KB, Nagaraj TS, Uddin Z, Ahmed I, Hwang K, et al. Maternal and fetal vascular lesions of malperfusion in the placentas associated with fetal and neonatal death: results of a prospective observational study. Am J Obstet Gynecol. 2021 Dec 1;225(6): 660.e1-660.e12.
Tidiani T, K S, B T, Bm S, A S, C S, et al. Hypertension Artérielle et Grossesse: Aspects Epidémio-cliniques et Complications à l’Hôpital Nianankoro Fomba de Ségou. Health Sci Dis [Internet]. 2021 Sep 4 [cited 2024 May 9];22(9). Available from: http://hsd-fmsb.org/index.php/hsd/article/view/2975
Njoku CO, Emechebe CI, Eyong EM, Ukaga JT, Anachuna KC. Prevalence and risk factors for stillbirths in a tertiary hospital in Niger Delta area of Nigeria: a ten-year review. Int J Med Biomed Res. 2016 Oct 3;5(3):106–13.
Mondal D, Galloway TS, Bailey TC, Mathews F. Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births. BMC Med. 2014 Dec;12(1):220.
Lankoande M, Bonkoungou P, Ouandaogo S, Dayamba M, Ouedraogo A, Veyckmans F, et al. Incidence and outcome of severe ante-partum hemorrhage at the Teaching Hospital Yalgado Ouédraogo in Burkina Faso. BMC Emerg Med. 2017 May 31 ;17(1):17.