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Abstract


RÉSUMÉ
Les inhibiteurs des transporteurs couplés sodium-glucose de type 2 représentent l’une des molécules de protection cardiovasculaire dans le traitement du diabète sucré. L’un de leurs effets secondaires est l’acidocétose. Nous rapportons les cas d’acidocétose recensés au Centre Hospitalier Sud Francilien chez des patients diabétiques traités par dapagliflozine. Nous rapportons l’observation médicale de 3 patients sur 5 mois. Etaient retrouvées une acidose métabolique avec une hyperglycémie. Les facteurs déclenchants étaient une infection pour deux patients et une déshydratation avec réduction des apports caloriques pour le 3e. L’éducation du patient et le dépistage précoce sont les clés de la prévention
Abstract
Type 2 sodium-glucose transporter inhibitors are one of the main cardiovascular protective molecules in the treatment of diabetes mellitus. One of their main adverse effects is ketoacidosis. We aimed to describe cases of ketoacidosis in diabetic patients treated with dapagliflozin at the Centre Hospitalier Sud Francilien. We identified 3 patients over 5-month. Were found a metabolic acidosis and hyperglycemia. The triggering factors were an infection for two patients and dehydration with reduced caloric intake for the third. Ketoacidosis in diabetic patients treated by i-SGLT2 is a life-threatening complication. Patient education and early detection are the keys of prevention.
Abréviations : i-SGLT2 (inhibiteurs des transporteurs couplés sodium-glucose de type 2), FDA (Food and Drug Administration), SAMU (Service d’Aide Médicale Urgente), DFG (Débit de Filtration Glomérulaire), DKA (Diabetes Keto Acidosis), min (minutes), FEVG (Fraction d’Ejection du Ventricule Gauche), SARM (Staphylococcus Aureus Résistant à la Méticilline)

Keywords

acidocétose, diabète sucré, dapaglifozine

Article Details

How to Cite
Astasselbe Abba Hadja Inna, Amadou Ibrahima, Martine Claude Etoa Etoga, Alfred Penfornis, & Eugène Sobngwi. (2023). L’Acidocétose chez le Sujet Diabétique Traité par Dapagliflozine. HEALTH SCIENCES AND DISEASE, 24(6). https://doi.org/10.5281/hsd.v24i6.4519

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