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Abstract
Introduction. Décrire les infections génitales basses (IGB) chez les patientes infectées par le VIH et suivies au CHU Sanou Sourô. Méthodologie. Étude prospective à visée descriptive qui s’est déroulée du 24 Octobre 2016 au 31 Janvier 2017. Ont été inclus toutes les patientes infectées par le VIH-1 sous traitement antirétroviral (ARV) à l’hôpital de jour adulte de Bobo-Dioulasso en consultation de suivi et ayant donné leur consentement éclairé. Résultats. Au total 306 patientes remplissaient les critères d’éligibilité. L’âge moyen était de 41,6 ans ±8,4 ans avec des extrêmes allant de 15 à 74 ans. Les femmes mariées étaient dominantes avec (51,70%) suivi des femmes veuves avec (29%). Les signes cliniques prédominants étaient les pertes blanches (45,42 %), suivi des démangeaisons (42,40%). Parmi les femmes, 198 (64,71%) avaient des leucorrhées épaisses, 4 avaient des leucorrhées filantes. Et 253 (82,68%) avaient des leucorrhées de couleur blanchâtres et 38 (12,42%) de couleur jaunâtre. Quarante-trois (14,05%) avaient un score de Nugent intermédiaire et 94 (30,72%) avaient une flore évocatrice d’une vaginose bactérienne .Et 188 (61,44%) patientes avaient une infection génitale basse. Parmi les 306 femmes, 282 (92,16%) patientes étaient infectées par le VIH-1. 240 (78,43%) patientes avaient un nombre de lymphocytes CD4 > à 500 cellules/µl et 290 avaient une charge virale indétectable. Conclusion. Cette étude montre l’existence des IGB chez les femmes infectées par le VIH au Burkina Faso bien qu’elles soient sous traitement ARV avec une charge virale indétectable.
ABSTRACT
Objective. To describe lower genital infections (GBI) in patients infected with HIV and monitored at the CHU Sanou Sourô. Methods. This was a prospective descriptive study which took place from October 24, 2016 to January 31, 2017. All patients infected with HIV-1 were included under ARV treatment at the adult day hospital in Bobo-Dioulasso in follow-up consultation and having given their informed consent. Results. A total of 306 patients met the eligibility criteria. Their mean age was 41.6 ± 8.4 years with extremes ranging from 15 to 74 years. Married women were dominant with (51.70%) followed by widowed women with (29%). The predominant clinical signs were white discharge (45.42%), followed by itching (42.40%). Among the women, 198 (64.71%) had thick leucorrhoea, 4 had stringy leucorrhoea. And 253 (82.68%) had whitish-colored leucorrhoea and 38 (12.42%) yellowish-colored. Forty-three (14.05%) had an intermediate Nugent score and 94 (30.72%) had a flora suggestive of bacterial vaginosis. And 188 (61.44%) patients had a lower genital infection. Among the 306 women, 282 (92.16%) patients were infected with HIV-1. 240 (78.43%) patients had CD4 lymphocyte counts> 500 cells/µl and 290 had an undetectable viral load. Conclusion. This study shows the existence of GBI in women infected with HIV in Burkina Faso although they are on ARV treatment with an undetectable viral load.
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References
- Mitchell C, Moreira C, Fredricks D, Paul K, Caliendo AM, et al. (2009) Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis. Infect Dis Obst et Gynecol 2009: 236919
- Alcaide ML, Chisembele M, Malupande E, Arheart K, Fischl M, Jones DL. A cross-sectional study of bacterial vaginosis, intravaginal practices and HIV genital shedding; implications for HIV transmission and women’s health. BMJ Open. 2015 Nov 9;5(11):e009036. doi: 10.1136/bmjopen-2015-009036
- Djigma F, Ouedraogo C, Ouermi D, Bisseyé C, Sagna T, Zeba M, et al. Co-infection de Mycoplasma hominis et de Ureaplasma urealyticum chez les femmes séropositives au VIH à Ouagadougou. Sci Tech. 2008 Jan-Déc;31(1&2):9-20
- Poda A, Hema A, Konaté A, Kaboré F, Zoungrana J, Kamboulé E, et al. Pregnancy rate and birth outcomes among women receiving antiretroviral therapy in Burkina Faso: a retrospective cohort study. Pan Afr Med J. 2016;23(1):105
- Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365: 493–505.
- Fredricks DN, Fiedler TL, Marrazzo JM (2005) Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353: 1899–1911.
- (UNAIDS) JUNPoHA (2010) Global report: UNAIDS report on the global AIDS epidemic 2010. New York: UNAIDS.
- Cohen CR, Lingappa JR, Baeten JM, Ngayo MO, Spiegel CA, Hong T, et al. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med. 2012;9:e1001251
- Poda A, Héma A, Ouédraogo AS, Zoungrana J, Konaté A, Kamboulé E, et al. Incidence et facteurs prédictifs de grossesse chez les femmes sous traitement antirétroviral à l’hôpital de jour de Bobo-Dioulasso, Burkina Faso. Burkina Méd. 2015;019(01): 41-50.
- Serris A, Zoungrana J, Diallo M, Toby R, Mpoudi Ngolle M, Le Gac S, et al. Getting pregnant in HIV clinical trials: women's choice and safety needs. The experience from the ANRS12169-2LADY and ANRS12286-MOBIDIP trials. HIV Clin Trials. 2016 Nov;17(6):233-241.
- Wessman M, Thorsteinsson K, Jensen JS, Storgaard M, Rönsholt F F, Johansen IS, and al. Bacterial vaginosis, human papilloma virus and herpes viridae do not predict vaginal HIV RNA shedding in women living with HIV in Denmark. BMC Infectious Diseases (2017) 17:376 DOI 10.1186/s12879-017-2477-7
- Moodley P, Connolly C, Sturma AW. Interrelationships among human immunodeficiency virus type 1 infection, bacterial vaginosis, trichomoniasis, and the presence of yeasts. J Infect Dis. 2002 Jan;185(1):69-73.
- Holzman C, Leventhal JM, Qiu H, Jones NM, Wang J. Factors linked to bacterial vaginosis in non pregnant women. Am J Public Health. 2001 Oct;91(10):1664-70
- Faye-Kette AYH, Sylla-Koko DF, Cisse ALF, Kacou-N’douba A, Akoua-Koffi G, Acho Yapo B et al. Aspects épidémiologiques et cliniques de la vaginose bactérienne à Abidjan. Méd Afr Noire. 1992;39(8/9):607-9
- Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, et al. (2010) .Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 375: 2092–2098
- Gjerdingen D, Fontaine P, Bixby M, Santilli J, Welsh J. The impact of regular vaginal pH screening on the diagnosis of bacterial vaginosis in pregnancy. J Fam Pract. 2000 Jan;49(1):39-43.
- Askienazy-Elbhar M. Le diagnostic bactériologique des vaginoses bactériennes en pratique de ville. Rev Fr Gynécol Obstét. 1993;88(3bis):203-6.
- Meda N, Ledru S, Fofana M, Lankoandé S, Soula G, Bazié AJ, et al. Sexually transmitted diseases and human immunodeficiency virus infection among women with genital infections in Burkina Faso. Int J STD AIDS, 1995 Jul-Aug;6(4):273-7
- Bukusi EA, Cohen CR, Meier AS, Waiyaki PG, Nguti R, et al. (2006) Bacterial vaginosis: risk factors among Kenyan women and their male partners. SexTransm Dis 33: 361–367.
- Sewankambo N, Gray RH, Wawer MJ, Paxton L, McNaim D, et al. (1997)HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet 350: 546–550.
- Kovacs A, Wasserman SS, Burns D, Wright DJ, Cohn J, Landay A, et al.Determinants of HIV-1 shedding in the genital tract of women. Lancet Lond Engl. 2001;358:1593–601
- Hovette P, Masseron T, Rault A, Blanc P. Les infections génitales basses à Djibouti. Méd Afr Noire. 1999;46(6):319-21
- Neely MN, Benning L, Xu J, Strickler HD, Greenblatt RM, Minkoff H, et al. Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 1999. 2007;44:38–42.
- Reimers LL, Mehta SD, Massad LS, Burk RD, Xie X, Ravel J, and al. The Cervicovaginal Microbiota and Its Associations With Human Papillomavirus Detection in HIV-Infected and HIV-Uninfected Women. J Infect Dis. 2016 Nov 1; 214(9): 1361–1369.
References
Mitchell C, Moreira C, Fredricks D, Paul K, Caliendo AM, et al. (2009) Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis. Infect Dis Obst et Gynecol 2009: 236919
Alcaide ML, Chisembele M, Malupande E, Arheart K, Fischl M, Jones DL. A cross-sectional study of bacterial vaginosis, intravaginal practices and HIV genital shedding; implications for HIV transmission and women’s health. BMJ Open. 2015 Nov 9;5(11):e009036. doi: 10.1136/bmjopen-2015-009036
Djigma F, Ouedraogo C, Ouermi D, Bisseyé C, Sagna T, Zeba M, et al. Co-infection de Mycoplasma hominis et de Ureaplasma urealyticum chez les femmes séropositives au VIH à Ouagadougou. Sci Tech. 2008 Jan-Déc;31(1&2):9-20
Poda A, Hema A, Konaté A, Kaboré F, Zoungrana J, Kamboulé E, et al. Pregnancy rate and birth outcomes among women receiving antiretroviral therapy in Burkina Faso: a retrospective cohort study. Pan Afr Med J. 2016;23(1):105
Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365: 493–505.
Fredricks DN, Fiedler TL, Marrazzo JM (2005) Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353: 1899–1911.
(UNAIDS) JUNPoHA (2010) Global report: UNAIDS report on the global AIDS epidemic 2010. New York: UNAIDS.
Cohen CR, Lingappa JR, Baeten JM, Ngayo MO, Spiegel CA, Hong T, et al. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. PLoS Med. 2012;9:e1001251
Poda A, Héma A, Ouédraogo AS, Zoungrana J, Konaté A, Kamboulé E, et al. Incidence et facteurs prédictifs de grossesse chez les femmes sous traitement antirétroviral à l’hôpital de jour de Bobo-Dioulasso, Burkina Faso. Burkina Méd. 2015;019(01): 41-50.
Serris A, Zoungrana J, Diallo M, Toby R, Mpoudi Ngolle M, Le Gac S, et al. Getting pregnant in HIV clinical trials: women's choice and safety needs. The experience from the ANRS12169-2LADY and ANRS12286-MOBIDIP trials. HIV Clin Trials. 2016 Nov;17(6):233-241.
Wessman M, Thorsteinsson K, Jensen JS, Storgaard M, Rönsholt F F, Johansen IS, and al. Bacterial vaginosis, human papilloma virus and herpes viridae do not predict vaginal HIV RNA shedding in women living with HIV in Denmark. BMC Infectious Diseases (2017) 17:376 DOI 10.1186/s12879-017-2477-7
Moodley P, Connolly C, Sturma AW. Interrelationships among human immunodeficiency virus type 1 infection, bacterial vaginosis, trichomoniasis, and the presence of yeasts. J Infect Dis. 2002 Jan;185(1):69-73.
Holzman C, Leventhal JM, Qiu H, Jones NM, Wang J. Factors linked to bacterial vaginosis in non pregnant women. Am J Public Health. 2001 Oct;91(10):1664-70
Faye-Kette AYH, Sylla-Koko DF, Cisse ALF, Kacou-N’douba A, Akoua-Koffi G, Acho Yapo B et al. Aspects épidémiologiques et cliniques de la vaginose bactérienne à Abidjan. Méd Afr Noire. 1992;39(8/9):607-9
Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, et al. (2010) .Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 375: 2092–2098
Gjerdingen D, Fontaine P, Bixby M, Santilli J, Welsh J. The impact of regular vaginal pH screening on the diagnosis of bacterial vaginosis in pregnancy. J Fam Pract. 2000 Jan;49(1):39-43.
Askienazy-Elbhar M. Le diagnostic bactériologique des vaginoses bactériennes en pratique de ville. Rev Fr Gynécol Obstét. 1993;88(3bis):203-6.
Meda N, Ledru S, Fofana M, Lankoandé S, Soula G, Bazié AJ, et al. Sexually transmitted diseases and human immunodeficiency virus infection among women with genital infections in Burkina Faso. Int J STD AIDS, 1995 Jul-Aug;6(4):273-7
Bukusi EA, Cohen CR, Meier AS, Waiyaki PG, Nguti R, et al. (2006) Bacterial vaginosis: risk factors among Kenyan women and their male partners. SexTransm Dis 33: 361–367.
Sewankambo N, Gray RH, Wawer MJ, Paxton L, McNaim D, et al. (1997)HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet 350: 546–550.
Kovacs A, Wasserman SS, Burns D, Wright DJ, Cohn J, Landay A, et al.Determinants of HIV-1 shedding in the genital tract of women. Lancet Lond Engl. 2001;358:1593–601
Hovette P, Masseron T, Rault A, Blanc P. Les infections génitales basses à Djibouti. Méd Afr Noire. 1999;46(6):319-21
Neely MN, Benning L, Xu J, Strickler HD, Greenblatt RM, Minkoff H, et al. Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 1999. 2007;44:38–42.
Reimers LL, Mehta SD, Massad LS, Burk RD, Xie X, Ravel J, and al. The Cervicovaginal Microbiota and Its Associations With Human Papillomavirus Detection in HIV-Infected and HIV-Uninfected Women. J Infect Dis. 2016 Nov 1; 214(9): 1361–1369.