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ABSTRACT
Pediatric acute kidney injury (PAKI) is a critical renal syndrome with multiple causes and multiple pathogenic mechanisms, and might have a poor prognosis if misdiagnosed or poorly managed. So early diagnosis is imperative to avoid delays in treatment. In recent years, some biomarkers have been developed, to predict the early occurrence of AKI, such as Neutrophil gelatinase associated lipocalin (NGAL), Kidney injury molecule-1 (KIM-1), Liver-type fatty acid binding protein (L-FABP), and Interleukin-18 (IL-18). Currently, PAKI lacks effective drug therapy, and renal replacement therapy (RRT) is the main treatment for AKI. Choosing the type of renal replacement therapy（RRT), must consider the patient's primary disease, clinical status, and the advantages and disadvantages. This article reviews the different most recent diagnostic markers of PAKI, and therapeutic interventions used.


RÉSUMÉ
La lésion rénale aigue en pédiatrie est un syndrome rénal grave avec de multiples causes et de multiples mécanismes pathogéniques qui pourraient avoir un mauvais pronostic si le diagnostic n’est pas posé ou mal traité. Un diagnostic précoce est donc impératif pour éviter les retards de traitement. Au cours des dernières années, certains biomarqueurs ont été développés pour prédire la survenue précoce de la lésion rénale aigue comme Neutrophil Gelatinase associated lipocalin (NGAL), Kidney injury molecule 1(KIM-1), Liver type fatty acid binding protein (L-FABP) et l’interleukin 18(IL-18). A l’heure actuelle, les lésions rénales aigues pédiatriques n’ont pas de traitement médicamenteux efficace et la thérapie de transplantation rénale est le principal traitement des lésions rénales aigues. Le choix du type de thérapie de remplacement rénal doit tenir compte de la maladie primaire du patient, de son état clinique, des avantages et inconvénients. Cet article passe en revue les différents marqueurs diagnostiques les plus récents de MRAP et les interventions thérapeutiques utilisées.

Keywords

acute pediatric kidney injury diagnosis biomarkers treatment

Article Details

Author Biography

Song Mei Fang, (1) The 20th Chineese Medical Team from Shan Xi, Yaounde Gynaeco- Obstetric and Pediatric hospital, Cameroon

Medical Imaging
How to Cite
Mei Fang, S., Hamo, S., & Chiabi, A. (2021). Progress in the Diagnosis and Management of Acute Kidney Injury in Children. HEALTH SCIENCES AND DISEASE, 22(3). https://doi.org/10.5281/hsd.v22i3.2573
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